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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/09/25 19:27:51」(JST)
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Diminazene
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Clinical data |
Trade names |
Azidin, Berenil, Ganasag, Pirocide |
Synonyms |
4,4'-(1-Triazene-1,3-diyl)bis(benzenecarboximidamide) |
Routes of
administration |
IM, SC |
ATCvet code |
- QP51AF01 (WHO) QP51AX07 (WHO)
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Legal status |
Legal status |
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Identifiers |
IUPAC name
- 4-[2-(4-Carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide
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CAS Number |
- 536-71-0
- aceturate: 908-54-3
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PubChem CID |
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ChemSpider |
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UNII |
- Y5G36EEA5Z
- aceturate: JI8SAD85NO
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ChEBI |
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ChEMBL |
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ECHA InfoCard |
100.007.860 |
Chemical and physical data |
Formula |
C14H15N7 |
Molar mass |
281.316 g/mol |
3D model (JSmol) |
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SMILES
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C1=CC(=CC=C1C(=N)N)N/N=N/C2=CC=C(C=C2)C(=N)N
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InChI
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InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
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Key:XNYZHCFCZNMTFY-UHFFFAOYSA-N
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Diminazene (INN; also known as diminazen) is an anti-infective medication for animals that is sold under a variety of brand names (see drugbox). It is effective against certain protozoa such as Babesia, Trypanosoma and Cytauxzoon. The drug may also be effective against certain bacteria including Brucella and Streptococcus.[1][2]
Chemically it is a di-amidine, and it is used in form of the aceturate (N-acetylglycinate).
The mechanism is not well understood; it probably inhibits DNA replication,[1] but also has affinity to RNA.
Side effects
Acute side effects include vomiting, diarrhoea and hypotension (low blood pressure). Diminazen can harm the liver, kidneys and brain, which is potentially life-threatening; especially camels are susceptible to these effects.[1]
References
- ^ a b c Peregrine, A. S.; Mamman, M. (1993). "Pharmacology of diminazene: A review". Acta tropica. 54 (3–4): 185–203. PMID 7902657. doi:10.1016/0001-706X(93)90092-P.
- ^ Mungube, E. O.; Vitouley, H. S.; Allegye-Cudjoe, E.; Diall, O.; Boucoum, Z.; Diarra, B.; Sanogo, Y.; Randolph, T.; Bauer, B.; Zessin, K. H.; Clausen, P. H. (2012). "Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali". Parasites & Vectors. 5: 155. PMC 3432589 . PMID 22852796. doi:10.1186/1756-3305-5-155.
English Journal
- In vitro and in vivo action of terpinen-4-ol, γ-terpinene, and α-terpinene against Trypanosoma evansi.
- Baldissera MD1, Grando TH2, Souza CF3, Gressler LT2, Stefani LM4, da Silva AS4, Monteiro SG5.
- Experimental parasitology.Exp Parasitol.2016 Jan 7. pii: S0014-4894(16)30004-2. doi: 10.1016/j.exppara.2016.01.004. [Epub ahead of print]
- This study aimed to evaluate the susceptibility in vitro and in vivo of Trypanosoma evansi to terpinen-4-ol, γ-terpinene and α-terpinene, the three main compounds of tea tree oil (Melaleuca alternifolia) with known efficacy in the treatment of trypanosomosis. In vitro, a trypanocidal effect of ter
- PMID 26773165
- Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.
- Wang L1, de Kloet AD2, Pati D1, Hiller H1, Smith JA1, Pioquinto DJ2, Ludin JA2, Oh SP2, Katovich MJ1, Frazier CJ1, Rsaizada MK2, Krause EG3.
- Neuropharmacology.Neuropharmacology.2016 Jan 5. pii: S0028-3908(15)30222-7. doi: 10.1016/j.neuropharm.2015.12.026. [Epub ahead of print]
- Over-activation of brain renin-angiotensin system (RAS) has been implicated in the etiology of anxiety disorders. Angiotensin converting enzyme (ACE2) inhibits RAS activity by converting angiotensin II, the effector peptide of RAS, to angiotensin-(1-7), which activates Mas receptors (MasR). Whether
- PMID 26767952
- Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats.
- De Maria ML, Araújo LD, Fraga-Silva RA, Pereira LA, Ribeiro HJ, Menezes GB, Shenoy V, Raizada MK, Ferreira AJ1.
- Protein and peptide letters.Protein Pept Lett.2016;23(1):9-16.
- Previous studies have shown that activation of endogenous angiotensin-converting enzyme 2 (ACE2) results in various beneficial effects in the cardiovascular system. Recently, a new ACE2 activator, named diminazene aceturate (DIZE), was described. Here, we evaluated the actions of this compound in bl
- PMID 26458404
Japanese Journal
- Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro
- Involvement of Mitochondrial Genes of <i>Babesia gibsoni</i> in Resistance to Diminazene Aceturate
- Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate