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Diminazen
|
|
| Systematic (IUPAC) name |
| 4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide |
| Clinical data |
| Trade names |
Azidin, Berenil, Ganasag, Pirocide |
|
Legal status
|
|
|
Routes of
administration
|
IM, SC |
| Identifiers |
|
CAS Registry Number
|
536-71-0
908-54-3 (aceturate) |
|
ATCvet code
|
QP51AF01 QP51AX07 |
| PubChem |
CID 2354 |
| ChemSpider |
2264 |
| UNII |
Y5G36EEA5Z Y |
| ChEBI |
CHEBI:81724 Y |
| ChEMBL |
CHEMBL124025 Y |
| Synonyms |
4,4'-(1-Triazene-1,3-diyl)bis(benzenecarboximidamide) |
| Chemical data |
| Formula |
C14H15N7 |
|
Molecular mass
|
281.316 g/mol |
SMILES
- C1=CC(=CC=C1C(=N)N)N/N=N/C2=CC=C(C=C2)C(=N)N
|
InChI
-
InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
Key:XNYZHCFCZNMTFY-UHFFFAOYSA-N
|
Diminazen(e) is an antiinfective drug for animals commercialized as Azidin, Berenil, Ganasag or Pirocide, directed, e.g., against infections with Babesia, Trypanosoma and Cytauxzoon and some bacteria such as Brucella and Streptococcus.[1][2]
Chemically it is a di-amidine, and it is used in form of the aceturate (N-acetylglycinate).
The mechanism is not well understood; it probably inhibits DNA replication,[1] but also has affinity to RNA.
Side effects
Acute side effects include vomiting, diarrhoea and hypotension (low blood pressure). Diminazen can harm liver, kidneys and brain, which is potentially life-threatening; especially camels are susceptible to these effects.[1]
See also
References
- ^ a b c Peregrine, A. S.; Mamman, M. (1993). "Pharmacology of diminazene: A review". Acta tropica 54 (3–4): 185–203. doi:10.1016/0001-706X(93)90092-P. PMID 7902657. edit
- ^ Mungube, E. O.; Vitouley, H. S.; Allegye-Cudjoe, E.; Diall, O.; Boucoum, Z.; Diarra, B.; Sanogo, Y.; Randolph, T.; Bauer, B.; Zessin, K. H.; Clausen, P. H. (2012). "Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali". Parasites & Vectors 5: 155. doi:10.1186/1756-3305-5-155. PMC 3432589. PMID 22852796. edit
English Journal
- Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense.
- Ademola IO1, Odeniran PO1.
- Pharmaceutical biology.Pharm Biol.2017 Dec;55(1):132-138. Epub 2016 Sep 21.
- PMID 27650882
- Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.
- Kamyingkird K1, Cao S2, Tuvshintulga B3, Salama A4, Mousa AA5, Efstratiou A3, Nishikawa Y3, Yokoyama N3, Igarashi I3, Xuan X6.
- Experimental parasitology.Exp Parasitol.2017 May;176:59-65. doi: 10.1016/j.exppara.2017.03.002. Epub 2017 Mar 9.
- PMID 28286324
- IgM, lgG and IL-6 profiles in the Trypanosoma brucei brucei monkey model of human African trypanosomiasis.
- Waema MW1, Maina NW1, Ngotho M2, Karanja SM3, Gachie BM1, Maranga DN4, Kagira JM5.
- Acta tropica.Acta Trop.2017 Apr;168:45-49. doi: 10.1016/j.actatropica.2017.01.012. Epub 2017 Jan 15.
- PMID 28099874
Japanese Journal
- Establishment of ATP-Based Luciferase Viability Assay in 96-Well Plate for Trypanosoma congolense
- Establishment of ATP-Based Luciferase Viability Assay in 96-Well Plate for Trypanosoma congolense
- Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro
Related Links
- ab143391 Diminazene aceturate （CAS番号: 908-54-3） 分子量: 515.52 化学式: C14H15N7.2C4H7NO3 Antitrypanosomal agent. ACE アクチベーター. アブカムの高純度な生理活性物質（アゴニスト・アンタゴニスト・アクティベーター・阻害 ...
- Diminazene | C14H15N7 | CID 2354 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. ... A chemical ...
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