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1. 内視鏡的逆行性胆管膵管造影（ERCP）後膵炎 post endoscopic retrograde cholangiopancreatography ercp pancreatitis
2. 持続的腎代替療法中の抗凝固療法 anticoagulation for continuous renal replacement therapy
3. 急性膵炎のマネージメント management of acute pancreatitis

English Journal

[Effect of KB-2796, a novel calcium channel blocker, on spreading depression in rat hippocampal slices].

Takagi H, Takashima M, Liou SY.SourceTsukuba Research Laboratories, Pharmacia & Upjohn, Ibaraki, Japan.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.Nihon Yakurigaku Zasshi.1998 May;111(5):309-16.
KB-2796, a novel calcium channel blocker, is under development as an anti-migraine drug. We examined its effects on spreading depression (SD) in rat hippocampal slices as compared with those of flunarizine, dimetotiazine and sumatriptan. Extracellular recording was made from the CA1 subfield. An SD,
PMID 9666486

Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 cells.

Watano T, Hara H, Sukamoto T.SourceDepartment of Pharmacology, New Drug Discovery Research Laboratory, Osaka, Japan.
Japanese journal of pharmacology.Jpn J Pharmacol.1997 Oct;75(2):209-13.
We investigated the effect of lomerizine, an anti-migraine drug, on the Ba2+ current through voltage-gated Ca2+ channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp technique. Lomerizine inhibited the Ba2+ current with an IC50 value of 1.9 microM. Lomerizine and nicardipine
PMID 9414039

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