ジメトチアジン
- 関
- dimetotiazine mesilate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/02 03:58:58」(JST)
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Dimetotiazine
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Systematic (IUPAC) name |
10-(2-dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
℞ Prescription only |
Routes |
Oral |
Identifiers |
CAS number |
7456-24-8 Y |
ATC code |
N02CX05 |
PubChem |
CID 3089 |
ChemSpider |
2979 N |
UNII |
1FTA475ZDB Y |
KEGG |
D07854 Y |
Chemical data |
Formula |
C19H25N3O2S2 |
Mol. mass |
391.55 g/mol |
SMILES
- CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C
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InChI
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InChI=1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3 N
Key:VWNWVCJGUMZDIU-UHFFFAOYSA-N N
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N (what is this?) (verify) |
Dimetotiazine (INN) is a phenothiazine used for the treatment of migraine.
It is a serotonin antagonist and histamine antagonist.[1]
References[edit]
- ^ Shimazawa M, Hara H, Watano T, Sukamoto T (August 1995). "Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats". Br. J. Pharmacol. 115 (8): 1359–68. PMC 1908864. PMID 8564192.
Antimigraine preparations (N02C)
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Analgesic/abortive |
Serotonin modulators
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Ergot alkaloids
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- Dihydroergotamine
- Ergotamine
- Methysergide
- Lisuride
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5-HT1 agonists
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- Triptans
- Almotriptan
- Avitriptan
- Eletriptan
- Frovatriptan
- Naratriptan
- Rizatriptan
- Sumatriptan
- Zolmitriptan
- Alniditan
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Other
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Other
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Prevention of migraines |
Beta blockers
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Calcium channel blocker
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Corticosteroid
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Monosaccharide
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Sympatholytics
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Tricyclic antidepressants
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- Amitriptyline
- Nortriptyline
- Imipramine
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Anticonvulsants
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- Valproate
- Carbamazepine
- Oxcarbazepine
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Ungrouped |
- Pizotifen
- Iprazochrome
- Dimetotiazine
- Oxetorone
- Lomerizine
- Telcagepant
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
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noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
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proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
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English Journal
- [Effect of KB-2796, a novel calcium channel blocker, on spreading depression in rat hippocampal slices].
- Takagi H, Takashima M, Liou SY.SourceTsukuba Research Laboratories, Pharmacia & Upjohn, Ibaraki, Japan.
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica.Nihon Yakurigaku Zasshi.1998 May;111(5):309-16.
- KB-2796, a novel calcium channel blocker, is under development as an anti-migraine drug. We examined its effects on spreading depression (SD) in rat hippocampal slices as compared with those of flunarizine, dimetotiazine and sumatriptan. Extracellular recording was made from the CA1 subfield. An SD,
- PMID 9666486
- Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 cells.
- Watano T, Hara H, Sukamoto T.SourceDepartment of Pharmacology, New Drug Discovery Research Laboratory, Osaka, Japan.
- Japanese journal of pharmacology.Jpn J Pharmacol.1997 Oct;75(2):209-13.
- We investigated the effect of lomerizine, an anti-migraine drug, on the Ba2+ current through voltage-gated Ca2+ channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp technique. Lomerizine inhibited the Ba2+ current with an IC50 value of 1.9 microM. Lomerizine and nicardipine
- PMID 9414039
Japanese Journal
- ラット海馬スライスにおけるSpreading depressionに対する新規カルシウム拮抗薬KB-2796の作用
- 高木 啓,高嶋 瑞夫,劉 世玉
- 日本薬理学雑誌 111(5), 309-316, 1998-05-01
- KB-2796は新規なカルシウム拮抗薬であり,抗片頭痛薬として開発中の化合物である.本研究では海馬切片を用いinvitroでのspreading depression (SD)に対するKB-2796の効果を,フルナリジン,ジメトチアジン,スマトリプタンの効果と比較検討した.ラット海馬CA1領域からフィールド電位を記録し,40?65秒間の低酸素負荷によりSDを誘発した後,自発性のSD発現を記録した. …
- NAID 10005085767
- Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca^<2+>-Channel Blocker, on Ba^<2+> Current through Voltage-Gated Ca^<2+> Channels in PC12 Cells
- WATANO Tomokazu,HARA Hideaki,SUKAMOTO Takayuki
- The Japanese journal of pharmacology 75(2), 209-213, 1997-10-01
- … 4 times more potent than flunarizine, diltiazem, verapamil and dimetotiazine. …
- NAID 10008189800
Related Links
- Dimetotiazine (INN) is a phenothiazine used for the treatment of migraine. It is a serotonin antagonist and histamine antagonist. References. ^ Shimazawa M, Hara H, Watano T, Sukamoto T (August 1995). "Effects of Ca2+ channel blockers on ...
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- dimetotiazine
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- メシル酸ジメトチアジン dimetotiazine mesilate、メシル酸ホナジン fonazine mesilate
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