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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/28 21:08:00」(JST)

Dimetindene (trade name Fenistil) is an antihistamine/anticholinergic used orally and topically as an antipruritic.^[1]

References

^ Wexler, L. (1962). "A Clinical Evaluation of Dimethindene". Current Therapeutic Research, Clinical and Experimental 4: 306–9. PMID 14006402.

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Life of lesions in eosinophilic cellulitis (Wells' syndrome)-a condition that may be missed at first sight.

Peckruhn M1, Tittelbach J, Schliemann S, Elsner P.
The American Journal of dermatopathology.Am J Dermatopathol.2015 Feb;37(2):e15-7. doi: 10.1097/DAD.0000000000000051.
Eosinophilic cellulitis is an inflammation of, until now, unknown etiology that was first described by George Wells in 1971. Its dominating histological hallmarks are so-called "flame figures" and an eosinophilic infiltrate. Here, we report the case of a 46-year-old man who initially presented with
PMID 25238447

Histamine H3 and H4 receptor ligands modify vascular histamine levels in normal and arthritic large blood vessels in vivo.

Kyriakidis K1, Zampeli E, Palaiologou M, Tiniakos D, Tiligada E.
Inflammation.Inflammation.2015;38(3):949-58. doi: 10.1007/s10753-014-0057-1.
Growing evidence associates histamine with arthritis, but its implication in shaping vascular function in chronic inflammation remains largely elusive. This study explored the involvement of vascular histamine in the extra-articular responses in peripheral large blood vessels using a rat model of ad
PMID 25359709

Role of histamine in altering fluid recycling in normal and post-traumatic rabbit peritoneum.

Kouritas VK1, Tepetes K, Spyridakis M, Theodosopoulou KV, Gourgoulianis KI, Molyvdas PA, Hatzoglou C.
Inflammation.Inflammation.2014 Apr;37(2):534-41. doi: 10.1007/s10753-013-9767-z.
This study aims to investigate if histamine induces electrochemical alterations in the normal and post-traumatic peritoneum. Peritoneal rabbit specimens were obtained before surgery and 10 days post-operatively and were mounted in Ussing chambers. Histamine solutions were added facing the intra-peri
PMID 24218196

Dimetindene
Systematic (IUPAC) name
	(RS)-dimethyl(2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine
Clinical data
Trade names	Fenistil
AHFS/Drugs.com	International Drug Names
Legal status	AU: S4 (Prescription only);
Routes of; administration	Oral, topical
Identifiers
CAS Number	5636-83-9 3614-69-5
ATC code	D04AA13 R06AB03
PubChem	CID 21855
DrugBank	DB08801
ChemSpider	20541
UNII	661FH77Z3P
KEGG	D07853
ChEMBL	CHEMBL22108
Chemical data
Formula	C20H24N2
Molar mass	292.418 g/mol
	SMILES n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C ;
	InChI InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 ; Key:MVMQESMQSYOVGV-UHFFFAOYSA-N ;
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