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Gymnopilins, a product of a hallucinogenic mushroom, inhibit the nicotinic acetylcholine receptor.

Kayano T1, Kitamura N2, Miyazaki S1, Ichiyanagi T1, Shimomura N1, Shibuya I1, Aimi T1.
Toxicon : official journal of the International Society on Toxinology.Toxicon.2014 Apr;81:23-31. doi: 10.1016/j.toxicon.2014.01.014. Epub 2014 Jan 31.
Gymnopilins are substances produced in fruiting bodies of the hallucinogenic mushroom, Gymnopilus junonius. Although, only a few biological effects of gymnopilins on animal tissues have been reported, it is believed that gymnopilins are a key factor of the G. junonius poisoning. In the present study
PMID 24491353

Dimethyl phenyl piperazine iodide (DMPP) induces glioma regression by inhibiting angiogenesis.

He YQ1, Li Y1, Wang XY1, He XD2, Jun L3, Chuai M4, Lee KK5, Wang J3, Wang LJ6, Yang X7.
Experimental cell research.Exp Cell Res.2014 Jan 15;320(2):354-64. doi: 10.1016/j.yexcr.2013.10.009. Epub 2013 Oct 23.
1,1-Dimethyl-4-phenyl piperazine iodide (DMPP) is a synthetic nicotinic acetylcholine receptor (nAChR) agonist that could reduce airway inflammation. In this study, we demonstrated that DMPP could dramatically inhibit glioma size maintained on the chick embryonic chorioallantoic membrane (CAM). We f
PMID 24162003

The anti-inflammatory effects of 1,1 dimethyl-4-phenylpiperazinium (DMPP) compared to dexamethasone in a guinea pig model of ovalbumin induced asthma.

Murad HA1, Hasanin AH.
European review for medical and pharmacological sciences.Eur Rev Med Pharmacol Sci.2014;18(15):2228-36.
BACKGROUND AND AIM: Inflammatory cells involved in the pathophysiology of asthma express nicotinic receptor. Therefore 1,1 dimethyl(-4-)phenylpiperazinium (DMPP) in two doses were compared to dexamethasone in asthmatic guinea pigs.MATERIALS AND METHODS: Six groups were included; Normal control and f
PMID 25070830