dimetacrine

Dimetacrine
Systematic (IUPAC) name
	3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
Clinical data
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	4757-55-5
ATC code	N06AA18
PubChem	CID 94280
ChemSpider	85085
UNII	O341NY501N
KEGG	D02565
Chemical data
Formula	C20H26N2
Mol. mass	294.43 g/mol
	SMILES CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C;

ジメタクリン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/22 02:56:01」(JST)

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Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.^[1]^[2]^[3]^[4]^[5] It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.^[6]^[7] Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants.

References[edit source | edit]

^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
^ Affective disorders: perspective on ... - Google Books.
^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 3-527-31058-4.
^ Taen S, Pöldinger W (December 1966). "[Dimethacrine (istonil), an acridane derivative with the antidepressive action]". Schweizerische Medizinische Wochenschrift (in German) 96 (48): 1616–20. PMID 6008540.
^ Meyer R (May 1968). "[Contribution to the clinical evaluation of the antidepressive effect of dimethacrine (Istonil)]". Praxis (in German) 57 (20): 721–3. PMID 5756370.
^ Abuzzahab FS (November 1973). "A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states". International Journal of Clinical Pharmacology, Therapy and Toxicology 8 (3): 244–53. PMID 4149236.
^ Mutschler, Ernst; Derendorf, Hartmut (1995). Drug actions: basic principles and therapeutic aspects. Stuttgart, Germany: Medpharm Scientific Pub. ISBN 0-8493-7774-9. Retrieved January 30, 2013.

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1. 成人における単極性うつ病と三環系抗うつ剤および四環系抗うつ剤：薬理学、投与、
および副作用 unipolar depression in adults and tricyclic and tetracyclic drugs pharmacology administration and side effects

English Journal

Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.

Kameyama T, Nagasaka M, Yamada K.
Neuropharmacology.Neuropharmacology.1985 Apr;24(4):285-90.
Mice experienced to electric shock, exhibited a marked suppression of motor activity when placed in the same cage 24 hr after administration of shocks. Acute administration of imipramine-HCl (10 mg/kg, i.p.), desipramine-HCl (5 and 10 mg/kg, i.p.) and amitriptyline-HCl (5 and 10 mg/kg, i.p.) caused
PMID 4039801

[Ataractic treatment in psychiatry and general medicine. Review of drugs. 5].

Hertrich O.
Fortschritte der Medizin.Fortschr Med.1983 Jul 14;101(26):1250, 1252.
PMID 6884962

[Pharmacokinetics of dimetacrine in rats (author's transl)].

Neye J, Fenner H.
Archiv der Pharmazie.Arch Pharm (Weinheim).1979 Jan;312(1):2-12.
PMID 426616

Japanese Journal

うつ病に対するNomifensineとDimetacrineの二重盲検比較試験

三田村幌 [他]
精神医学 24(9), p973-988, 1982-09-00
NAID 40002058313

iemetacrine tartrateとT_3の併用により低TSH反応の改善をみたDepressionの1例

筒井末春,難波経彦,橋本信一,山崎毅樹
心身医学 18(4), 321-326, 1978-08-01
… A 45-year old male was treated by triiodothyronine 10γ per day in combination with dimetacrine tartrate because of his sstained depressive symptom.Low TSH response to TRH test was found without the abnormalites of thyroidal functions.After teh combined treatment, the patient showed an improvement quickly in parallel wtih the improvement of low TSH response.TRH test as well as the combined treatmetn for depression by T_3 and antidepressant were reviewed in the literature. …
NAID 110001119399

Binding of H3-imipramine, H3-dimetacrine and S35-chlorpromazine to synaptosomes.

Ishitani Ryoichi,Iwamoto Takio
The Japanese Journal of Pharmacology 28(1), 85-92, 1978
… Binding of H3-imipramine, H3-dimetacrine and S35-chlorpromazine to synaptosomes of rat cerebral cortex was studied using a centrifugation method, and kinetic analysis of the experimental data. …
NAID 130000839306