dihydrotachysterol

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/09/30 20:37:39」(JST)

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Not to be confused with Dihydrotestosterone.

Dihydrotachysterol

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a682335
ATC code	A11CC02 (WHO)
Identifiers
IUPAC name (1S,3E,4S)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohexan-1-ol
CAS Number	67-96-9 Y
PubChem CID	5311071
DrugBank	DB01070 Y
ChemSpider	4470607 Y
UNII	R5LM3H112R
KEGG	D00299 Y
ChEBI	CHEBI:4591 Y
ECHA InfoCard	100.000.611
Chemical and physical data
Formula	C28H46O
Molar mass	398.664 g/mol
3D model (JSmol)	Interactive image
SMILES O[C@@H]3C/C(=C\C=C1/CCC[C@]2([C@H]1CC[C@@H]2[C@@H](/C=C/[C@H](C)C(C)C)C)C)[C@@H](C)CC3
InChI InChI=1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+/t20-,21-,22+,25-,26+,27-,28+/m0/s1 Y Key:ILYCWAKSDCYMBB-OPCMSESCSA-N Y
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Dihydrotachysterol (DHT) is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D₂ (ergocalciferol) and vitamin D₃ (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D.

UpToDate Contents

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• 1. 骨軟化症の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of osteomalacia
• 2. 成人におけるビタミンD欠乏症：定義、臨床症状、および治療 vitamin d deficiency in adults definition clinical manifestations and treatment
• 3. 低カルシウム血症の治療 treatment of hypocalcemia
• 4. 副甲状腺機能低下症 hypoparathyroidism

English Journal

• Surgery of benign thyroid disease by ENT/head and neck surgeons and general surgeons: 233 cases of vocal fold paralysis in 3509 patients.

• Kohnen B, Schürmeyer C, Schürmeyer TH, Kress P.
• European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2018 Sep;275(9)2397-2402.
• Thyroid surgery is mainly performed by general surgeons (GS). The aim of this study is to evaluate the safety and efficiency of thyroid surgery by ENT/head and neck surgeons (ENT), especially regarding the incidence of vocal fold palsy (VFP). We retrospectively analysed 3509 patients (69.0% female)
• PMID 30074074

• [Severe hypercalcemia of unusual cause, looking for the culprit: Case report and review of the literature].

• Jalbert M, Mignot A, Gauchez AS, Dobrokhotov AC, Fourcade J.
• Nephrologie & therapeutique. 2018 Jun;14(4)231-236.
• Hypercalcemia is not a rare event and can lead to severe consequences. Its main etiologies are primary hyperparathyroidism and neoplasic conditions. The iatrogenic etiology by vitamin D intoxication is more rarely found. A 76-year-old finish woman comes to the emergency room for chest pain. Her medi
• PMID 29709532

• Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome.

• Chaudhary MK, Rizvi SI.
• Analytical cellular pathology (Amsterdam). 2018 ;2018()5028925.
• Increased oxidative stress is a major cause of aging and age-related diseases. Erythrocytes serve as good model for aging studies. Dihydrotachysterol is known to induce premature aging feature in rats mimicking Hutchinson-Gilford progeria syndrome. In the present study, attempts have been made to ex
• PMID 30003010

Japanese Journal

• 原発性副甲状腺機能こう進症に慢性すい炎を合併し２０年の経過後，腎不全にて死亡した１剖検症例

• 医療 49(2), 175-178, 1995
• NAID 130004315115

• ラット顎下腺の実験的石灰化に関する研究

• 歯基礎誌 29(6), 664-683, 1987
• NAID 130004001505

• <原著>慢性透析症例の腎性骨異栄養症に対する活性型vitamin D_3 analogue剤長期投与の効果

• 近畿大学医学雑誌 10(4), 339-345, 1985-12-25
• NAID 110000059900

Related Links

• Dihydrotachysterol medical facts from Drugs.com

Physician reviewed dihydrotachysterol patient information - includes dihydrotachysterol description, dosage and directions. ... Dihydrotachysterol dosing information Usual Adult Dose for Hypocalcemia: Initial dose: 0.25 to 0.8 mg ...

• Dihydrotachysterol - brand name list from Drugs.com

Lists the various brand names available for medicines containing dihydrotachysterol. Find information on dihydrotachysterol use, treatment, drug class and molecular formula. ... Disclaimer: The indications, uses and warnings for ...

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