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1. 脳血管性認知症の治療および予防 treatment and prevention of vascular dementia
2. 内視鏡的逆行性胆管膵管造影（ERCP）後膵炎 post endoscopic retrograde cholangiopancreatography ercp pancreatitis
3. 持続的腎代替療法中の抗凝固療法 anticoagulation for continuous renal replacement therapy
4. 急性膵炎のマネージメント management of acute pancreatitis

English Journal

Drugs to treat Alzheimer's disease.

[No authors listed]
Journal of psychosocial nursing and mental health services.J Psychosoc Nurs Ment Health Serv.2013 Apr;51(4):11-2. doi: 10.3928/02793695-20130306-99.
PMID 23565878

Preparation of ergoloid mesylate submicron emulsions for enhancing nasal absorption and reducing nasal ciliotoxicity.

Yu C1, Meng J, Chen J, Tang X.Author information 1Department of Pharmaceutics, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.AbstractThe aim of this investigation was to prepare ergoloid mesylate submicron emulsions (EMSEs) for enhancing nasal absorption of drug and reducing nasal ciliotoxicity. Following intranasal administrations of EMSE and ergoloid mesylate solution (EMS) and intravenous administration of EMS to rats separately at the dose of 2 mg kg(-1), the levels of EM in blood and the cerebrospinal fluid (CSF) were evaluated by microdialysis method. The nasal ciliotoxicity was evaluated by using in situ toad palate model. The absolute bioavailability and the AUC in the CSF following intranasal administration of EMSE (56.3 +/- 5.3%, AUC(CSF) 28,594 +/- 5680 ng ml(-1) min) were statistically higher than those after intranasal administration of EMS (47.4 +/- 3.5%, AUC(CSF) 19,870 +/- 2247 ng ml(-1) min). No significant difference was found for the value of the brain drug direct transport percentage (DTP%) or the drug targeting efficiency (DTE) between the group receiving EMSE and the group receiving EMS. In conclusion, EMSE exhibited higher nasal absorption of EM in rats and significantly lower nasal ciliotoxicity whereas no greater brain-targeting efficiency in comparison with EMS.
International journal of pharmaceutics.Int J Pharm.2009 Jun 22;375(1-2):16-21.
The aim of this investigation was to prepare ergoloid mesylate submicron emulsions (EMSEs) for enhancing nasal absorption of drug and reducing nasal ciliotoxicity. Following intranasal administrations of EMSE and ergoloid mesylate solution (EMS) and intravenous administration of EMS to rats separate
PMID 19504748