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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/22 04:04:33」(JST)

English Journal

Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults.

Hemmingsen JG1, Rissler J2, Lykkesfeldt J3, Sallsten G4, Kristiansen J5, P PM6, Loft S7.
Particle and fibre toxicology.Part Fibre Toxicol.2015 Mar 19;12(1):6. doi: 10.1186/s12989-015-0081-9.
BACKGROUND: Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects are poorly described.METHODS: Sixty healthy subjects (25 males, 35 females, ag
PMID 25890359

Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase.

Yang S1, Jan YH1, Mishin V1, Richardson JR1, Hossain MM1, Heindel ND1, Heck DE1, Laskin DL1, Laskin JD2.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2015 Mar;352(3):529-40. doi: 10.1124/jpet.114.221572. Epub 2014 Dec 30.
Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical for nitric oxide biosynthesis and alkylglycerol and aromatic amino acid metabolism. SPR also mediates chemical redox cycling, catalyzing one-
PMID 25550200

Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation.

Yeo TW1, Lampah DA2, Kenangalem E2, Tjitra E3, Price RN4, Weinberg JB5, Hyland K6, Granger DL7, Anstey NM8.
PLoS pathogens.PLoS Pathog.2015 Mar 12;11(3):e1004667. doi: 10.1371/journal.ppat.1004667. eCollection 2015.
Tetrahydrobiopterin (BH₄) is a co-factor required for catalytic activity of nitric oxide synthase (NOS) and amino acid-monooxygenases, including phenylalanine hydroxylase. BH4 is unstable: during oxidative stress it is non-enzymatically oxidized to dihydrobiopterin (BH₂), which inhibits NOS. Dep
PMID 25764397

一瀬宏,小柴梢子,本田俊一郎 [他],徳岡宏文
ビタミン 85(10), 547-551, 2011-10-25
… Because BH4 is easily oxidized to dihydrobiopterin (BH2), the ratio of BH4 to BH2 could be an index of the oxidative stress in the cell. …
NAID 110008762042

小柴梢子,徳岡宏文,横山照夫 [他],堀内恵美子,長谷川一子,一瀬宏
ビタミン 85(2), 63-69, 2011-02-25
… Here, we report the levels of pteridines, i.e. BH_4, dihydrobiopterin, biopterin, dihydroneopterin, neopterin, in the cerebrospinal fluids (CSF) of patients with neurological diseases including sporadic Parkinson's disease (sPD), frontotemporal dementia (FTD), multiple system atrophy (MSA), and meningitis. …
NAID 110008460671

リンク元	「ジヒドロビオプテリン」

Dihydrobiopterin
Names
	IUPAC name 2-Amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-1H-pteridin-4-one
	Other names 7,8-Dihydrobiopterin
Identifiers
CAS Registry Number	6779-87-9
Jmol-3D images	Image
PubChem	252
	SMILES CC(C(C1=NC2=C(NC1)NC(=NC2=O)N)O)O ;
Properties
Chemical formula	C9H13N5O3
Molar mass	239.24 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references