WordNet

spread out; not concentrated in one place; "a large diffuse organization"
move outward; "The soldiers fanned out" (同)spread, spread out, fan out
lacking conciseness; "a diffuse historical novel"
an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin (同)dermatosclerosis
(of light rays) subjected to scattering by reflection from a rough surface or transmission through a translucent material; "diffused light"
genus of poisonous fungi having hard-skinned fruiting bodies: false truffles (同)genus Scleroderma
spreading by diffusion (同)diffusive, dispersive, disseminative

PrepTutorEJDIC

〈光・熱・液体など〉‘を'散らす,放散する,拡散させる / 〈学問・知識など〉‘を'広める,普及させる / 散る,放散する,拡散する / 広まる,普及する / 広く散った,広がった / 〈文体などが〉締まりのない,散漫な

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1. 成人における全身性硬化症（強皮症）の臨床症状の概要 overview of the clinical manifestations of systemic sclerosis scleroderma in adults
2. 強皮症の概要および分類 overview and classification of scleroderma disorders
3. 成人における全身性硬化症（強皮症）の治療および予後の概要 overview of the treatment and prognosis of systemic sclerosis scleroderma in adults
4. 成人における全身性硬化症（強皮症）の診断および鑑別診断 diagnosis and differential diagnosis of systemic sclerosis scleroderma in adults
5. 全身性硬化症（強皮症）における肺合併症の概要 overview of pulmonary complications of systemic sclerosis scleroderma

Cardiac Biomarkers in Systemic Sclerosis: Contribution of High-Sensitivity Cardiac Troponin in Addition to N-Terminal Pro-Brain Natriuretic Peptide.

Avouac J1, Meune C2, Chenevier-Gobeaux C3, Borderie D3, Lefevre G4, Kahan A5, Allanore Y1.
Arthritis care & research.Arthritis Care Res (Hoboken).2015 Jul;67(7):1022-30. doi: 10.1002/acr.22547.
OBJECTIVE: To measure plasma concentrations of high-sensitivity cardiac troponin T (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with systemic sclerosis (SSc; scleroderma) and age- and sex-matched healthy control subjects, and to examine the contribution of tradition
PMID 25604469

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients.

Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R.
The Journal of clinical investigation.J Clin Invest.2015 Jul 1;125(7):2795-2807. doi: 10.1172/JCI77958. Epub 2015 Jun 22.
BACKGROUND: TGF-β has potent profibrotic activity in vitro and has long been implicated in systemic sclerosis (SSc), as expression of TGF-β-regulated genes is increased in the skin and lungs of patients with SSc. Therefore, inhibition of TGF-β may benefit these patients.METHODS: Patients with e
PMID 26098215

Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemic sclerosis EUSTAR population.

Hachulla E1, Clerson P1, Airò P1, Cuomo G1, Allanore Y1, Caramaschi P1, Rosato E1, Carreira PE1, Riccieri V1, Sarraco M1, Denton CP1, Riemekasten G1, Pozzi MR1, Zeni S1, Mihai CM1, Ullman S1, Distler O1, Rednic S1, Smith V1, Walker UA1, Matucci-Cerinic M1, Müller-Ladner U1, Launay D1; EUSTAR co-workers.
Rheumatology (Oxford, England).Rheumatology (Oxford).2015 Jul;54(7):1262-9. doi: 10.1093/rheumatology/keu450. Epub 2015 Jan 17.
OBJECTIVE: The aim of this study was to assess the prognostic value of systolic pulmonary artery pressure (sPAP) estimated by echocardiography in the multinational European League Against Rheumatism Scleroderma Trial and Research (EUSTAR) cohort.METHODS: Data for patients with echocardiography docum
PMID 25596413

鳥越雅隆,前島圭佑,清永恭弘,今田千晴,尾崎貴士,原中美環,石井宏治,柴田洋孝
臨床リウマチ 26(4), 310-316, 2014
症例は59歳女性．2012年に全身性強皮症と診断された．翌年４月，血栓性微小血管障害症に強皮症腎クリーゼを併発し，更に急性心不全も伴っていた．ACE阻害薬の内服や血液透析，血漿交換などで加療され，また重症心筋障害にはステロイドパルスが奏功した．直後に肺胞出血を生じたが，厳格な呼吸循環管理と上記治療の継続で病状は安定した．重篤かつ多彩な病態に対し集学的治療で救命し得た全身性強皮症の一例を報告す …
NAID 130005067609

Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis

Makino Katsunari,Jinnin Masatoshi,Makino Takamitsu,Kajihara Ikko,Fukushima Satoshi,Inoue Yuji,Ihn Hironobu
BioScience Trends 8(3), 144-148, 2014
… Patients diagnosed as scleroderma spectrum disorder (SSD), who did not fulfill the ACR criteria of SSc but were thought that they might develop SSc in the future, were also included in this study. … SSD patients had significantly lower CA IX levels than diffuse cutaneous SSc (dcSSc), limited cuntaneous SSc (lcSSc) and healthy control groups. …
NAID 130004572597

Glucocorticoid-induced Normotensive Scleroderma Renal Crisis: A Report on Two Cases and a Review of the Literature in Japan

Maruyama Akihito,Nagashima Takao,Ikenoya Kohei,Aoki Yoko,Matsuyama Yasushi,Iwamoto Masahiro,Minota Seiji
Internal Medicine 52(16), 1833-1837, 2013
… We herein report the findings of 2 cases of normotensive scleroderma renal crisis (SRC) that developed soon after the commencement of a glucocorticoid therapy. … The common characteristics of these 8 cases are as follows: the recent onset of systemic sclerosis, the presence of diffuse skin sclerosis, the presence of myositis and/or serositis, a high titer of antinuclear antibody and positivity for anti-Scl-70 antibody. …
NAID 130003365753