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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/18 11:14:14」(JST)
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Dienestrol
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Systematic (IUPAC) name |
4-[4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy cat. |
? |
Legal status |
? |
Pharmacokinetic data |
Protein binding |
50 to 80% |
Identifiers |
CAS number |
84-17-3 N |
ATC code |
G03CB01 G03CC02 |
PubChem |
CID 667476 |
DrugBank |
DB00890 |
ChemSpider |
580857 Y |
UNII |
RRW32X4U1F Y |
KEGG |
D00898 Y |
ChEMBL |
CHEMBL1018 Y |
Chemical data |
Formula |
C18H18O2 |
Mol. mass |
266.334 g/mol |
SMILES
- Oc2ccc(C(/C(c1ccc(O)cc1)=C/C)=C\C)cc2
|
InChI
-
InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+ Y
Key:NFDFQCUYFHCNBW-SCGPFSFSSA-N Y
|
N (what is this?) (verify)
|
Dienestrol is a synthetic estrogen.
Chemistry
References
- Dodds, E. C.; Goldberg, L.; Lawson, W.; Robinson, R.; Proc. Roy. Soc. (London) 1939, B127, 148.
External links
- http://dx.doi.org/10.1098/rspb.1939.0015
Estrogenics
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Receptor |
ER (α, β)
|
|
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GPER
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- Agonists: Estradiol
- Fulvestrant
- G-1
- Genistein
- Quercetin
- Tamoxifen
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|
|
Enzyme
(inhibitors) |
20,22-Desmolase
|
- 22-ABC
- 3,3′-Dimethoxybenzidine
- 3-Methoxybenzidine
- Aminoglutethimide
- Cyanoketone
- Danazol
- Etomidate
- Mitotane
- Trilostane
|
|
17α-Hydroxylase,
17,20-Lyase
|
- 22-ABC
- 22-Oxime
- Abiraterone
- Bifonazole
- Clotrimazole
- Cyanoketone
- Cyproterone
- Danazol
- Econazole
- Galeterone
- Gestrinone
- Isoconazole
- Ketoconazole
- L-39
- Liarozole
- LY-207,320
- MDL-27,302
- Miconazole
- Mifepristone
- Orteronel
- Pioglitazone
- Rosiglitazone
- Spironolactone
- Stanozolol
- SU-10,603
- TGF-β
- Tioconazole
- Troglitazone
- VN/87-1
- YM116
|
|
3β-HSD
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- 4-MA
- Azastene
- Cyanoketone
- Danazol
- Epostane
- Genistein
- Gestrinone
- Metyrapone
- Oxymetholone
- Pioglitazone
- Rosiglitazone
- Trilostane
- Troglitazone
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17β-HSD
|
|
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Aromatase
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- 1,4,6-Androstatriene-3,17-dione
- 4-Androstene-3,6,17-trione
- 4-Cyclohexylaniline
- 4-Hydroxytestosterone
- 5α-DHNET
- Abyssinone II
- Aminoglutethimide
- Anastrozole
- Ascorbic acid (Vitamin C)
- Atamestane
- Bifonazole
- CGP-45,688
- CGS-47,645
- Clotrimazole
- DHT
- Difeconazole
- Econazole
- Exemestane
- Fadrozole
- Fenarimol
- Finrozole
- Formestane
- Imazalil
- Isoconazole
- Ketoconazole
- Letrozole
- Liarozole
- MEN-11066
- Miconazole
- Minamestane
- Nimorazole
- NKS01
- ORG-33,201
- Penconazole
- Plomestane
- Prochloraz
- Propioconazole
- Pyridoglutethimide
- Rogletimide
- Rotenone
- Talarozole
- Testolactone
- Tioconazole
- Triadimefon
- Triadimenol
- Troglitazone
- Vorozole
- YM511
- Zinc
Note: 5α-reductase and 21-hydroxylase inhibitors may also affect estrogen levels as they prevent metabolism of estrogen steroid precursors.
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Other |
Endogenous
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- Estrogens: 5α-Androstane-3β,17β-diol
- DHEA
- Estetrol
- Estradiol
- Estriol
- Estrone
- Antiestrogens: 2-Hydroxyestrone
- 16-Hydroxyestrone
- Precursors: Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- Cortodoxone/Deoxycortisol
- DHEA
- DHEA sulfate
- 16-Hydroxy-DHEA
- 16-Hydroxy-DHEA sulfate
- Androstenediol
- Androstenedione
- 16-Hydroxyandrostenedione
- Testosterone
|
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Indirect
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- Androgens/Antiandrogens (see here)
- Calcitriol (a form of Vitamin D)
- GnRH agonists/antagonists (see here)
- Gonadotropins//Antigonadotropins (see here)
- Plasma proteins (SHBG, ABP, Albumin)
- Progestogens/Antiprogestins (see here)
- Prolactin
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Procedures
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- Adrenalectomy
- Hypophysectomy
- Oophorectomy
- Orchiectomy
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|
English Journal
- Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry.
- Xu Q, Wang M, Yu S, Tao Q, Tang M.SourceMinistry of Education Key Laboratory of Environmental Medicine and Engineering, School of Public Health, Southeast University, Nanjing, 210009, China.
- The Analyst.Analyst.2011 Dec 7;136(23):5030-7. Epub 2011 Oct 12.
- A simple, rapid and sensitive method for the determination of diethylstilbestrol (DES), dienestrol (DE) and hexestrol (HEX) was developed by using the Nylon 6 nanofibers mat-based solid-phase extraction (SPE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS). These estrogens were s
- PMID 21994916
- Solid-phase extraction using molecularly imprinted polymer for selective extraction of natural and synthetic estrogens from aqueous samples.
- Lucci P, Núñez O, Galceran MT.SourceDepartment of Analytical Chemistry, University of Barcelona, Barcelona, Spain. paololucci2001@yahoo.it
- Journal of chromatography. A.J Chromatogr A.2011 Jul 29;1218(30):4828-33. Epub 2011 Feb 13.
- A method is proposed for the clean-up and preconcentration of natural and synthetic estrogens from aqueous samples employing molecularly imprinted polymer (MIP) as selective sorbent for solid-phase extraction (SPE). The selectivity of the MIP was checked toward several selected natural and synthetic
- PMID 21356538
Japanese Journal
- Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines
- Roner Michael R.,Carraher Charles E. Jr.,Shahi Kimberly,Ashida Yuki,Barot Girish
- BMC CANCER 9, 2009
- NAID 120004710151
- 培養哺乳類細胞によるエストロゲンのがん化機構の研究 -^<32>P-ポストラベリング法によるDNA付加体の検出-
- 筒井 健機
- 日本薬理学雑誌 110(1), 1-9, 1997-07-01
- … DNA adduct formation is detected in cells treated with DES, but not in cells treated with either α-or β-dienestrol. … Similarly, morphological transformation of SHE calls is induced by treatment with DES, but not by treatment with α-or β-dienestrol. …
- NAID 10005708460
- Simultaneous determination, in calf urine, of twelve anabolic agents as heptafluorobutyryl derivatives by capillary gas chromatography-mass spectrometry
- CASADEMONT G.,PEREZ B.,GARCIA REGUEIRO J. A.
- Journal of chromatography. B, Biomedical applications 686(2), 189-198, 1996-11-15
- NAID 10012418849
Related Links
- Dienestrol. From Wikipedia, the free encyclopedia. Jump to: navigation, search. Dienestrol. Systematic (IUPAC) name ... Dienestrol is a synthetic estrogen. Dienestrol.png. [edit] References. Dodds, E. C.; Goldberg, L.; Lawson, W.; Robinson, R.
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