English Journal

Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition.

Liu Y1, He X1, Sui Y1, Yu R2, Xu G3.
FEBS letters.FEBS Lett.2015 Aug 4;589(17):2233-40. doi: 10.1016/j.febslet.2015.06.044. Epub 2015 Jul 13.
Immunomodulatory drugs such as thalidomide, lenalidomide, and pomalidomide exhibit high responsive rates for newly identified or relapsed multiple myeloma patients. However, their mechanisms of action are not completely understood. One mechanism involves the ubiquitination and degradation of two tra
PMID 26183205

Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis.

Padmanabhan J1, Brown KR2, Padilla A3, Shelanski ML2.
The Journal of biological chemistry.J Biol Chem.2015 Feb 27;290(9):5267-79. doi: 10.1074/jbc.M114.575225. Epub 2015 Jan 7.
KCl withdrawal-induced apoptosis in cerebellar granule neurons is associated with aberrant cell cycle activation, and treatment with cyclin-dependent kinase (Cdk) inhibitors protects cells from undergoing apoptosis. Because the Cdk inhibitor flavopiridol is known to inhibit RNA polymerase II (Pol II
PMID 25568312

Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells.

Wang ZQ1, Johnson CL1, Kumar A1, Molkentine DP1, Molkentine JM1, Rabin T1, Mason KA1, Milas L1, Raju U2.
Anticancer research.Anticancer Res.2014 Dec;34(12):6981-9.
BACKGROUND: Positive transcription elongation factor-b (P-TEFb) is a complex containing CDK9 and a cyclin (T1, T2 or K). The effect of inhibition of P-TEFb by 5,6-dichloro-l-β-D-ribofuranosyl benzimidazole (DRB) on cell radiosensitivity and the underlying mechanisms were investigated.MATERIALS AND
PMID 25503124