diazepam binding inhibitor

ジアゼパム結合阻害タンパク質

関

endozepine

WordNet

1. executed with proper legal authority; "a binding contract"
2. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
3. strip sewn over or along an edge for reinforcement or decoration
4. the capacity to attract and hold something
5. limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
6. control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
7. limit the range or extent of; "Contact between the young was inhibited by strict social customs"
8. a substance that retards or stops an activity
9. a tranquilizer (trade name Valium) used to relieve anxiety and relax muscles; acts by enhancing the inhibitory actions of the neurotransmitter GABA; can also be used as an anticonvulsant drug in cases of nerve agent poisoning (同)Valium

PrepTutorEJDIC

1. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
2. 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
3. 抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/03 20:29:54」(JST)

wiki en

[Wiki en表示]

Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
PDB rendering based on 1aca.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CB8, 2FJ9
Identifiers
Symbols	DBI ; ACBD1; ACBP; CCK-RP; EP
External IDs	OMIM: 125950 MGI: 94865 HomoloGene: 39086 GeneCards: DBI Gene
EC number	3.4.17.3
Gene ontology Molecular function • lipid binding • benzodiazepine receptor binding • long-chain fatty acyl-CoA binding • protein dimerization activity Cellular component • mitochondrion • endoplasmic reticulum • Golgi apparatus • extracellular exosome • perinuclear endoplasmic reticulum Biological process • behavioral fear response • hair follicle development • triglyceride metabolic process • transport • learning or memory • protein palmitoylation • lateral ventricle development • phosphatidylcholine acyl-chain remodeling • long-term synaptic potentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1622	13167
Ensembl	ENSG00000155368	ENSMUSG00000026385
UniProt	P07108	P31786
RefSeq (mRNA)	NM_001079862	NM_001037999
RefSeq (protein)	NP_001073331	NP_001033088
Location (UCSC)	Chr 2: 119.37 – 119.37 Mb	Chr 1: 120.11 – 120.12 Mb
PubMed search	[1]	[2]

Acyl-CoA-binding protein is a protein that in humans is encoded by the DBI gene.

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland.

Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.

See also

Diazepam

References

Further reading

• Papadopoulos V, Brown AS (1995). "Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis.". J. Steroid Biochem. Mol. Biol. 53 (1–6): 103–10. doi:10.1016/0960-0760(95)00027-W. PMID 7626442. 
• Costa E, Auta J, Guidotti A et al. (1994). "The pharmacology of neurosteroidogenesis". J. Steroid Biochem. Mol. Biol. 49 (4–6): 385–9. doi:10.1016/0960-0760(94)90284-4. PMID 8043504. 
• Mandrup S, Hummel R, Ravn S et al. (1993). "Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family". J. Mol. Biol. 228 (3): 1011–22. doi:10.1016/0022-2836(92)90888-Q. PMID 1469708. 
• Webb NR, Rose TM, Malik N et al. (1987). "Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand". DNA 6 (1): 71–9. doi:10.1089/dna.1987.6.71. PMID 2881742. 
• Gray PW, Glaister D, Seeburg PH et al. (1986). "Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor". Proc. Natl. Acad. Sci. U.S.A. 83 (19): 7547–51. doi:10.1073/pnas.83.19.7547. PMC 386756. PMID 3020548. 
• DeBernardi MA, Crowe RR, Mocchetti I et al. (1988). "Chromosomal localization of the human diazepam binding inhibitor gene". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6561–5. doi:10.1073/pnas.85.17.6561. PMC 282013. PMID 3413112. 
• Marquardt H, Todaro GJ, Shoyab M (1986). "Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor". J. Biol. Chem. 261 (21): 9727–31. PMID 3525533. 
• Swinnen JV, Esquenet M, Heyns W et al. (1995). "Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP". Mol. Cell. Endocrinol. 104 (2): 153–62. doi:10.1016/0303-7207(94)90118-X. PMID 7527352. 
• Kolmer M, Rovio A, Alho H (1995). "The characterization of two diazepam binding inhibitor (DBI) transcripts in humans". Biochem. J. 306 (Pt 2): 327–30. PMC 1136524. PMID 7534063. 
• Gersuk VH, Rose TM, Todaro GJ (1995). "Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor". Genomics 25 (2): 469–76. doi:10.1016/0888-7543(95)80047-P. PMID 7789980. 
• Alho H, Kolmer M, Harjuntausta T, Helén P (1995). "Increased expression of diazepam binding inhibitor in human brain tumors". Cell Growth Differ. 6 (3): 309–14. PMID 7794798. 
• Alho H, Vaalasti A, Podkletnova I, Rechardt L (1994). "Expression of diazepam-binding inhibitor peptide in human skin: an immunohistochemical and ultrastructural study". J. Invest. Dermatol. 101 (6): 800–3. doi:10.1111/1523-1747.ep12371698. PMID 8245508. 
• Cavallaro S, Pani L, Guidotti A, Costa E (1993). "ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action". Life Sci. 53 (14): 1137–47. doi:10.1016/0024-3205(93)90550-M. PMID 8396705. 
• Swinnen JV, Esquenet M, Rosseels J et al. (1996). "A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP". DNA Cell Biol. 15 (3): 197–208. doi:10.1089/dna.1996.15.197. PMID 8634149. 
• Krøll JB, Nøhr J, Gregersen N et al. (1996). "Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man. Addendum". Gene 173 (2): 239–40. doi:10.1016/0378-1119(96)00214-4. PMID 8964506. 
• Kolmer M, Pelto-Huikko M, Parvinen M et al. (1997). "The transcriptional and translational control of diazepam binding inhibitor expression in rat male germ-line cells". DNA Cell Biol. 16 (1): 59–72. doi:10.1089/dna.1997.16.59. PMID 9022045. 
• Ferrarese C, Cogliati T, Tortorella R et al. (1998). "Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients". Epilepsy Res. 29 (2): 129–34. doi:10.1016/S0920-1211(97)00074-0. PMID 9477145. 

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 小児における志賀毒素が関連した（典型的）溶血性尿毒症症候群の治療および予後 treatment and prognosis of shiga toxin associated typical hemolytic uremic syndrome in children
• 2. 再生不良性貧血：病因、臨床症状および診断 aplastic anemia pathogenesis clinical manifestations and diagnosis
• 3. 選択的セロトニン再取り込み阻害剤中毒 selective serotonin reuptake inhibitor poisoning
• 4. 中等度および重度のアルコール離脱症候群のマネージメント management of moderate and severe alcohol withdrawal syndromes
• 5. 妊娠女性におけるうつ病：管理 depression in pregnant women management

English Journal

• A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis.

• Setoguchi N, Takamura N, Fujita K, Ogata K, Tokunaga J, Nishio T, Chosa E, Arimori K, Kawai K, Yamamoto R.SourceSecond Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki, 882-8508, Japan.
• Biopharmaceutics & drug disposition.Biopharm Drug Dispos.2013 Mar;34(2):125-36. doi: 10.1002/bdd.1829. Epub 2013 Jan 24.
• Diclofenac suppository, a non-steroidal anti-inflammatory drug (NSAID), is used widely in rheumatoid arthritis (RA) patients with severe arthritic pain. As the binding percentage of diclofenac to serum proteins is high, its free (unbound) concentration after rectal administration is low. To increase
• PMID 23225308

• Gliotransmission and brain glucose sensing: critical role of endozepines.

• Lanfray D, Arthaud S, Ouellet J, Compère V, Do Rego JL, Leprince J, Lefranc B, Castel H, Bouchard C, Monge-Roffarello B, Richard D, Pelletier G, Vaudry H, Tonon MC, Morin F.SourceINSERM U982, DC2N Laboratory of Neuronal and Neuroendocrine Cell Differentiation and Communication, Mont-Saint-Aignan, France.
• Diabetes.Diabetes.2013 Mar;62(3):801-10. doi: 10.2337/db11-0785. Epub 2012 Nov 16.
• Hypothalamic glucose sensing is involved in the control of feeding behavior and peripheral glucose homeostasis, and glial cells are suggested to play an important role in this process. Diazepam-binding inhibitor (DBI) and its processing product the octadecaneuropeptide (ODN), collectively named endo
• PMID 23160530

• RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism.

• Mills JD, Nalpathamkalam T, Jacobs HI, Janitz C, Merico D, Hu P, Janitz M.SourceSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
• Neuroscience letters.Neurosci Lett.2013 Mar 1;536:90-5. doi: 10.1016/j.neulet.2012.12.042. Epub 2013 Jan 7.
• The parietal cortex of the human brain plays a unique role in the coordination of movement and in the integration of signals from the other cortices. Because of its extensive connections and involvement in many higher-order cognitive functions, neurodegenerative changes in the parietal lobe are beli
• PMID 23305720

Japanese Journal

• Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland

• Tsukagoshi Eri,Kawaguchi Mitsuru,Shinomiya Takashi [他],YOSHIKAWA Masanobu,KAWANO Toshihiko,OKUBO Migiwa,SAWAKI Kohei
• Journal of pharmacological sciences 115(2), 221-229, 2011-02-20
• … Diazepam-binding inhibitor (DBI), an endogenous ligand for PBR, produces neurosteroids, which modulate CBR activity. … In this study, we investigated the effect of repetitive administration of diazepam (DZP) on salivary secretion and expression of DBI mRNA and peptide. …
• NAID 10029892190

• Chronic administration of methamphetamine increases the mRNA expression of diazepam binding inhibitor in rat brain

• Tamaki R
• Tokai J Exp Clin Med 33, 46-50, 2008
• NAID 80019467573

• DIAZEPAM-BINDING INHIBITOR-DERIVED PEPTIDES-INDUCED ANOREXIGENIC ACTION IS MEDIATED THROUGH THE METABOTROPIC ENDOZEPINE RECEPTOR IN GOLDFISH

• WADA Kohei,MIURA Tohru,MARUYAMA Keisuke,SHIMAKURA Sei-Ichi,UCHIYAMA Minoru,LEPRINCE Jerome,TONON Marie-Christine,VAUDRY Hubert,MATSUDA Kouhei
• Proceedings of the Japan Society for Comparative Endocrinology (22), 28, 2007-10-12
• NAID 10020188373

Related Links

• Diazepam Binding Inhibitor - RightDiagnosis.com

Diazepam Binding Inhibitor information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Diazepam Binding Inhibitor Description of Diazepam Binding Inhibitor ...

• Diazepam binding inhibitor (DBI): a peptide with multiple ...

1. Life Sci. 1991;49(5):325-44. Diazepam binding inhibitor (DBI): a peptide with multiple biological actions. Costa E, Guidotti A. Fidia-Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, Washington ...

---

★リンクテーブル★

リンク元	「ジアゼパム結合阻害タンパク質」「endozepine」
関連記事	「binding」「inhibit」「inhibitor」「diazepam」

「ジアゼパム結合阻害タンパク質」

　　[★]

英

diazepam binding inhibitor

関

エンドゼピン

「endozepine」

　　[★]

エンドゼピン

関

diazepam binding inhibitor

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「inhibit」

　　[★]

• v.

• 抑制する、阻害する、阻止する

関

abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression

　 　 　 　

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「diazepam」

　　[★] ジアゼパム

同

Valium