デキストラノマー
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/24 15:39:22」(JST)
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Dextranomer
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Systematic (IUPAC) name |
Dextran, 2,3-dihydroxypropyl 2-hydroxy-1,3-propanediyl ethers
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Clinical data |
Trade names |
Debrisan |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Topical |
Identifiers |
CAS Registry Number |
56087-11-7 N |
ATC code |
D03AX02 |
PubChem |
SID: 214362 |
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N (what is this?) (verify) |
Dextranomer (trade name Debrisan) is a cicatrizant used in dressings for wound healing,[1] and in pharmaceutical products to treat fecal incontinence.[2] It consists of dextran polymer chains cross-linked into a three-dimensional network.[3]
Solesta
Solesta is the marketed brand name of a system of injections of dextranomer in stabilized sodium hyaluronate for use in fecal incontinence (FI).[4] This preparation is a biocompatible gel, for use as a perianal injectable bulking agent. The system is intended to be injected in the submucosal layer of the proximal anal canal (i.e. above the level of the dentate line).
References
- ^ Parulkar BG, Sobti MK, Pardanani DS (1985). "Dextranomer dressing in the treatment of infected wounds and cutaneous ulcers". J Postgrad Med 31 (1): 28–33.
- ^ Solesta Gel Approved for Fecal Incontinence
- ^ Solesta Package Insert
- ^ Hoy, SM (Aug 20, 2012). "Dextranomer in stabilized sodium hyaluronate (Solesta): in adults with faecal incontinence.". Drugs 72 (12): 1671–8. doi:10.2165/11209030-000000000-00000. PMID 22845415.
External links
- dextranomer at the US National Library of Medicine Medical Subject Headings (MeSH)
Preparations for treatment of wounds and ulcers (D03)
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Cicatrizants |
- epichlorohydrin: Cadexomer iodine
- Crilanomer
- Dextranomer
- B5: Calcium pantothenate
- Dexpanthenol
- nitrate: Nitroglycerin
- Isosorbide dinitrate
- other: Becaplermin
- Enoxolone
- Hyaluronic acid
- Tetrachlorodecaoxide
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Proteolytic enzymes |
- Bromelain
- Clostridiopeptidase
- Trypsin
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Index of skin
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Description |
- Anatomy
- Physiology
- Development
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Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Neutrophilic and eosinophilic
- Congenital
- Neoplasms and cancer
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
- Terminology
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Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
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UpToDate Contents
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English Journal
- The Biocompatibility of a Cellulose Exopolysaccharide Implant in the Rabbit Bladder When Compared With Dextranomer Microspheres Plus Hyaluronic Acid.
- Lima SV1, de Oliveira Rangel AE2, de Melo Lira MM3, Pinto FC4, Campos Júnior O4, Sampaio FJ5, de Andrade Aguiar JL6.
- Urology.Urology.2015 Apr 11. pii: S0090-4295(15)00203-4. doi: 10.1016/j.urology.2015.02.028. [Epub ahead of print]
- OBJECTIVE: To evaluate biocompatibility of a cellulosic exopolysaccharide (CEC) as bulking agent in rabbit urinary bladder.MATERIALS AND METHODS: The experimental study was developed at the Nucleus for Experimental Surgery or UFPE. The new agent was injected into the bladder of the adult rabbits usi
- PMID 25872698
- A novel use of dextranomer/hyaluronic acid copolymer.
- Lambropoulos V1, Mouravas V, Papageorgiou I, Spyridakis I, Marakis G.
- Urologia.Urologia.2015 Mar 20;82(1):71-3. doi: 10.5301/uro.5000065. Epub 2014 May 14.
- The aim of this study is to present a novel use of Dextranomer/hyaluronic acid copolymer (Deflux) for the treatment of a complicated iatrogenic chronic urethral injury. A 12-year-old boy with a neuropathic bladder presented a groove in the urethral mucosa due to chronic clean intermittent catheteriz
- PMID 24832471
- Factors affecting the success of endoscopic treatment of vesicoureteral reflux and comparison of two dextranomer based bulking agents: Does bulking substance matter?
- Dogan HS1, Altan M2, Citamak B2, Bozaci AC2, Koni A2, Tekgul S2.
- Journal of pediatric urology.J Pediatr Urol.2015 Mar 2. pii: S1477-5131(15)00045-5. doi: 10.1016/j.jpurol.2014.12.009. [Epub ahead of print]
- INTRODUCTION: Among the interventional treatment modalities for vesicoureteral reflux (VUR), endoscopic subureteric injection seems to be the least invasive method with acceptable outcomes when applied in appropriate patients.OBJECTIVE: The aim of the presented study is to investigate the parameters
- PMID 25791422
Japanese Journal
- 膀胱尿管逆流症に対する非動物由来安定化ヒアルロン酸ナトリウム/デキストラノマー・ゲル(NASHA^<TM>/Dxゲル)注入療法 : 日本人患者を対象とした多施設共同オープン試験
- 谷風 三郎,長 雄一,多田 実 [他],合谷 信行,浅沼 宏,山崎 雄一郎,島田 憲次,杉多 良文,後藤 隆文,山口 孝則
- 日本泌尿器科學會雜誌 101(5), 676-682, 2010-07-20
- (目的)非動物由来安定化ヒアルロン酸ナトリウム/デキストラノマー・ゲル(NASHA^<TM>/Dxゲル)を尿管口周囲に注入する内視鏡的注入療法の有効性と安全性を評価するため,日本人膀胱尿管逆流症(VUR)患者を対象とした多施設共同オープン試験を行った.試験成績について報告する.(対象と方法)逆流グレードII〜IVの1歳以上のVUR患者にNASHA/Dxゲルを内視鏡的に注入し,注入3, …
- NAID 110007682272
- Nonanimal stabilized hyaluronic acid/Dextranomer Gel(Deflux^[○!R])を用いた膀胱尿管逆流症に対する内視鏡治療
- 藤本 隆夫,諏訪 智英,石井 のぞみ
- 日本小児外科学会雑誌 46(2), 220-228, 2010-04-20
- … 【目的】小児膀胱尿管逆流症患児16例,25尿管(国際分類II度4尿管,III度9尿管,IV度12尿管)に対し,nonanimal stabilized hyaluronic acid/Dextranomer Gel(Deflux^[○!R]:Q-Med)を用いた内視鏡下治療法を施行し,術後3か月,1年後の治療効果についての評価を行った.【対象および方法】治療施行時年齢は6か月〜5歳8か月(平均2歳2か月)である.尿管口へのDeflux^[○!R]の注入はHydrodistension Implantation Technique法を用いた.【結果】平均手術時間は19.9±11.3分,Deflux^[ …
- NAID 110007593917
- 腹圧性尿失禁の既往をもち診断困難であった医原性尿管膣瘻の1例
- 渡辺 美穂,山西 友典,釜井 隆男 [他],古谷 信隆,福田 武彦,吉田 謙一郎
- 泌尿器科紀要 55(11), 721-724, 2009-11
- … Periurethral injection with non-animal stabilized hyaluronic acid/ dextranomer was performed. …
- NAID 120001712081
Related Links
- Dextranomer (trade name Debrisan) is a cicatrizant used in dressings for wound healing, and in pharmaceutical products to treat fecal incontinence. It consists of dextran polymer chains cross-linked into a three-dimensional network.
- dextranomer /dex·trano·mer/ (deks-tran´o-mer) small beads of highly hydrophilic dextran polymers, used in débridement of secreting wounds, such as venous stasis ulcers; the sterilized beads are poured over secreting wounds to absorb ...
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