dexketoprofen

Dexketoprofen
Systematic (IUPAC) name
	(2S)-2-[3-(benzoyl)phenyl]propanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	POM (UK)
Identifiers
ATC code	M01AE17
PubChem	CID 667550
ChemSpider	580922
UNII	6KD9E78X68
KEGG	D07269
Chemical data
Formula	C16H14O3
Mol. mass	254.28056 g/mol
	SMILES C[C@@H](c1cccc(c1)C(=O)c2ccccc2)C(=O)O;
	InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1; Key:DKYWVDODHFEZIM-NSHDSACASA-N ;
(what is this?) (verify);

デクスケトプロフェン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/24 11:20:32」(JST)

wiki en

[Wiki en表示]

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as dexketoprofen trometamol, as a prescription-only drug and in Latin America as Enantyum, produced by Menarini. Also, in Italy and Spain it is available as an over the counter-drug under the tradename respectively Enantyum, Ketesgel. In Lithuania it is available as over the counter-drug under tradename Dolmen. In Mexico it is available in tablet form as "Stadium" made by Menarini in Luxemburg.

Indications [edit]

Short-term treatment of mild to moderate pain, including dysmenorrhoea.

Pharmacology [edit]

Dexketoprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.

Warning [edit]

This medicine may cause dizziness and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
For fast relief of pain, take at least 30 minutes before food, as food delays the absorption of this medicine from the gut.
This medicine is not for long term use

Use with caution in [edit]

Decreased heart function
Disorders involving the formation of blood cells (haematopoietic disorders)
Elderly people
Excess retention of water in the body tissues (fluid retention)
History of allergies
Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
Low volume of circulating blood (hypovolaemia)
Mild to moderately decreased liver function
Mildly decreased kidney function
Syndrome with symptoms of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon (mixed connective tissue disease)

Not to be used in [edit]

Active bleeding
Allergy to any of its ingredients
Allergy to aspirin or other medicines in this class
Asthma or history of asthma
Bleeding disorders
Bleeding from the stomach or intestines
Breastfeeding
Children
Crohn's disease
History of stomach or duodenal ulcers or indigestion
Inflammation of the bowel and back passage
Inherited tendency to bleed (haemorrhagic diathesis)
Moderate to severely decreased kidney function
Peptic ulcers
Pregnancy
Severe heart failure
Severely decreased liver function

Label warnings [edit]

Take this medication half to one hour before eating in order to facilitate quick absorption in case of acute pain. As a precautionary measure, it is advised to take dexketoprofen during meals at an interval of 8 hours.

Dose [edit]

In the USA: Adult: 12.5 mg every 4–6 hours, or 25 mg every 8 hours; max 75 mg daily. Elderly: initially max 50 mg daily. Child: not recommended.

In Europe: As prescribed, the dosage is variable being consistent with the nature, severity and duration of the pain episode. Currently the prescribed amount is 25 mg every 8 hours, although the daily dosage should not exceed 75 mg. In elderly patients, light to moderate liver and renal failure, the maximum dosage is set at a maximum of 50 mg/24h. Dexketoprofen is currently not prescribed to children under the age of 18.

Citations [edit]

[1]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 成人における片頭痛の急性期治療 acute treatment of migraine in adults

English Journal

Comparison of the Effects of Meloxicam and Dexketoprofen on Postoperative Adhesion Formation in a Rat Uterine Horn Surgical Model.

Keskin HL, Akkus SM, Sirin YS, Ustuner I, Keles H, Ide T, Avsar AF.SourceDepartment of Gynecology and Obstetrics, Atatürk Education and Research Hospital, Ankara, Turkey. Electronic address: hlkeskin@yahoo.com.
Journal of minimally invasive gynecology.J Minim Invasive Gynecol.2013 Jan 5. pii: S1553-4650(12)01314-3. doi: 10.1016/j.jmig.2012.11.003. [Epub ahead of print]
STUDY OBJECTIVE: To compare the effects of 2 nonsteroidal antiinflammatory drugs of different chemical classes (meloxicam and dexketoprofen) on postoperative intraabdominal adhesion formation in a rat model.DESIGN: Experimental study (Canadian Task Force classification I).SETTING: Center for researc
PMID 23298631

Drug-induced life-threatening potassium disturbances detected by a pharmacovigilance program from laboratory signals.

Ramírez E, Rossignoli T, Campos AJ, Muñoz R, Zegarra C, Tong H, Medrano N, Borobia AM, Carcas AJ, Frías J.SourceClinical Pharmacology Deparment, Hospital Universitario La Paz (IdiPaz), School of Medicine, Universidad Autónoma de Madrid, Arzobispo Morcillo s/n, 28029, Madrid, Spain, elena.ramirez@uam.es.
European journal of clinical pharmacology.Eur J Clin Pharmacol.2013 Jan;69(1):97-110. doi: 10.1007/s00228-012-1303-9. Epub 2012 May 31.
PURPOSE: Detection and reporting of drug-induced life-threatening potassium disturbances and the study of associated factors under a Pharmacovigilance Program using Laboratory Signals at a Hospital (PPLSH) during a 2-year period.METHODS: All serum potassium levels <2 mmol/l or >7 mmol/l dete
PMID 22648277