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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/06 13:20:32」(JST)

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  • Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension.
  • Dempsie Y, Macritchie NA, White K, Morecroft I, Wright AF, Nilsen M, Loughlin L, Mair KM, Maclean MR.SourceInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, Glasgow University, West Medical Building, Glasgow G12 8QQ, UK.
  • Cardiovascular research.Cardiovasc Res.2013 Apr 23. [Epub ahead of print]
  • AIMS: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. D
  • PMID 23519266
  • Pulmonary hypertension associated with benfluorex exposure.
  • Savale L, Chaumais MC, Cottin V, Bergot E, Frachon I, Prevot G, Pison C, Dromer C, Poubeau P, Lamblin N, Habib G, Reynaud-Gaubert M, Bourdin A, Sanchez O, Tubert-Bitter P, Jaïs X, Montani D, Sitbon O, Simonneau G, Humbert M.SourceUniv Paris-Sud, Faculte de Medecine and AP-HP Centre de Reference del’Hypertension Pulmonaire Severe, Service de Pneumologie et SoinsIntensifs, Hopital Bicetre, Le Kremlin Bicetre, France
  • The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology.Eur Respir J.2012 Nov;40(5):1164-72. doi: 10.1183/09031936.00188611. Epub 2012 Apr 20.
  • Benfluorex was marketed in France until 2009, despite its similar pharmacological properties with fenfluramine and its derivatives known to be a cause of pulmonary arterial hypertension (PAH). The aim of this study is to report clinical and haemodynamic characteristics for patients suffering from pu
  • PMID 22523367
  • CB1 receptor antagonists: new discoveries leading to new perspectives.
  • Kirilly E, Gonda X, Bagdy G.SourceDepartment of Pharmacodynamics, Semmelweis University, Budapest, Hungary.
  • Acta physiologica (Oxford, England).Acta Physiol (Oxf).2012 May;205(1):41-60. doi: 10.1111/j.1748-1716.2012.02402.x.
  • CB(1) receptor antagonists were among the most promising drug targets in the last decade. They have been explored and found to be effective as therapeutic agents for obesity and related cardiometabolic problems; however, use of rimonabant, the first marketed CB(1) receptor antagonist, has been sus
  • PMID 22463610


  • Fenfluramine/Dexfenfluramine と心臓弁膜症について
  • 渡邉 ひかる,久保田 潔
  • 臨床薬理 = Japanese journal of clinical pharmacology 40(1), 41-46, 2009-01-31
  • NAID 10026157474
  • 中国製ダイエット用健康食品中のN-nitrosofenfluramineの光学純度の決定
  • 中台 亜里,稲垣 弘文,南 正康,高橋 秀依,南目 梨江,大沢 基保,池上 四郎
  • 藥學雜誌 123(9), 805-809, 2003-09-01
  • 2001年から2002年夏にかけて,中国製ダイエット用健康食品による健康被害が相ついで報告され,社会問題にまでなったのは記憶に新しい.その主な被害は,劇症肝炎や急性肝炎など,重篤な肝障害であり,死者が出るまでに至った.既に厚生労働省は,問題のダイエット食品中から,3-5%の濃度でN-nitrosofenfluramineが検出されたことを報告している.さらに,その後行われた国立医薬品食品衛生研究所 …
  • NAID 110003614927


dex·fen·flu·ra·mine / ˌdɛks fɛnˈflʊər əˌmin / Show Spelled [deks-fen-fl oo r-uh-meen] Show IPA noun Pharmacology. an adrenergic drug, a form of fenfluramine, formerly used in treating obesity but withdrawn from the market in 1997 ...
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