WordNet
- a corticosteroid drug (trade names Decadron or Dexamethasone Intensol or Dexone or Hexadrol or Oradexon) used to treat allergies or inflammation (同)Decadron, Dexamethasone Intensol, Dexone, Hexadrol, Oradexon
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/20 11:43:52」(JST)
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Dexamethasone isonicotinate
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| Names |
| IUPAC name
[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyridine-4-carboxylate
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| Other names
Auxiloson/ Dexamethasone 21-isonicotinate/ Auxilson/ Auxilsone/ Voren/ DEXAMETHASONE ISONICOTINATE/ EINECS 218-866-5/ HE 111/ 2265-64-7/ Pyridine-4-carboxylic acid-(dexamethasone-21') ester/ Pyridin-4-carbonsaeure-(dexamethason-21')-ester [German]/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((4-pyridinylcarbonyl)oxy)-, (11beta,16alpha)/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-isonicotinate/ Auxison/ Voren [veterinary] (TN)/ UNII-8LGC0BOA71/ AC1L28M0/ C28H32FNO6/ HE-111/ LS-118477/ D07797/ Pyridin-4-carbonsaeure-(dexamethason-21')-ester/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-,21-isonicotinate
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| Identifiers |
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CAS Number
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2265-64-7 |
| ChemSpider |
15881 |
| Jmol interactive 3D |
Image |
| PubChem |
16752 |
| UNII |
8LGC0BOA71 Y |
InChI
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InChI=1/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1
Key: BQTXJHAJMDGOFI-NJLPOHDGBY
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SMILES
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O=C(OCC(=O)[C@@]3(O)[C@H](C)C[C@H]2[C@@H]4CCC\1=C\C(=O)\C=C/[C@]/1(C)[C@@]4(F)[C@@H](O)C[C@@]23C)c5ccncc5
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| Properties |
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Chemical formula
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C28H32FNO6 |
| Molar mass |
497.56 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references |
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This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (July 2009) |
See also: dexamethasone
Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause salt and water retention.
References
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Glucocorticoids and antiglucocorticoids (H02)
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| Agonists |
| Pregnene |
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| Pregnenedione |
- Hydrocortisone (cortisol)# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- Halogenated at 6: Cloprednol
- Halogenated, with FG at 16: Halcinonide
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| Pregnadiene |
- Rimexolone
- Halogenated, with FG at 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
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| Pregnadienediol |
- Prednisone (Meprednisone)
- Halogenated at 9: Fluorometholone
- Halogenated, with FG at 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
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| Pregnadienetriol |
- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- Halogenated: Fluprednisolone (Difluprednate
- Fluperolone)
- Halogenated, with FG at 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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| Pregnatriene |
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| Androstene |
- Halogenated, with FG at 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
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| Others/unsorted |
- Halogenated: Loteprednol
- Halogenated, with FG at 16: Fludroxycortide
- Formocortal
- Mometasone furoate
- Promestriene
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Antagonists /
SGRMs |
- Antagonists: Ketoconazole
- Mifepristone
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| Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of hormones
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| Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
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| Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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Glucocorticoid signaling
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Receptor
(ligands) |
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GR
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Agonists
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Mixed (SEGRAs)
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- Dagrocorat
- Fosdagrocorat
- Mapracorat
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Antagonists
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- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- Aglepristone
- Asoprisnil
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Guggulsterone
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- Org 34850
- Pregnenolone 16α-carbonitrile
- Spironolactone
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
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| Enzyme |
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Modulators
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- See here instead (modulators of 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase).
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| Others |
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Precursors/prohormones
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- Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- 11-Deoxycorticosterone
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Indirect
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- ACTH (corticotropin)
- CRH
- DHEA
- DHEA sulfate
- Plasma proteins (albumin, transcortin)
- Vasopressin
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See also: Androgenics • Estrogenics • Mineralocorticoids • Progestogenics
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UpToDate Contents
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English Journal
- Effects of Dexamethasone-21-Isonicotinate on Peripheral Insulin Action in Dairy Cows 5 days after Surgical Correction of Abomasal Displacement.
- Kusenda M, Kaske M, Piechotta M, Locher L, Starke A, Huber K, Rehage J.SourceClinic for Cattle, University of Veterinary Medicine Hannover, 30173, Hannover, Germany.
- Journal of veterinary internal medicine / American College of Veterinary Internal Medicine.J Vet Intern Med.2012 Nov 29. doi: 10.1111/jvim.12010. [Epub ahead of print]
- BACKGROUND: Dexamethasone frequently is used for treatment of ketosis in dairy cows, but its effects are not fully understood.HYPOTHESIS: Dexamethasone treatment affects whole body insulin sensitivity.ANIMALS: Twelve German Holstein cows, 2-4 weeks postpartum, 5 days after omentopexy to correct le
- PMID 23194055
- Effects of anabolic and therapeutic doses of dexamethasone on thymus morphology and apoptosis in veal calves.
- Cannizzo FT, Miniscalco B, Riondato F, Bollo E, Barbarino G, Giorgi P, Mazzini C, Biolatti B.SourceDipartimento di Patalogia Animale, University of Turin, via L. Da Vinci 44, 10095 Grugliasco, TO, Italy.
- The Veterinary record.Vet Rec.2008 Oct 11;163(15):448-52.
- Three groups of 10 veal calves were treated, respectively, with 5 mg of dexamethasone-21-isonicotinate administered intramuscularly on days 0 and 7 (group A); 0.4 mg/day of dexamethasone-21-phosphate administered orally for 20 days (group B); or left untreated as controls (group C). Two animals from
- PMID 18849577
Japanese Journal
- 気管内吸入用Dexamethasone-21-isonicotinate(He111)のマウス,ラットによる急性毒性
- 気管内吸入用Dexamethasone-21-isonicotinate(He111)の一般薬理-1-
- 気管内吸入用Dexamethasone-21-isonicotinate(He111)のラットによる亜急性および慢性毒性
Related Links
- [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16- trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]- 2-oxoethyl]pyridine-4-carboxylate. Other names. Auxiloson/ Dexamethasone ...
- A professional monograph about Dexamethasone 21 Isonicotinate for Veterinary Use by Barbara Forney, VMD.
Related Pictures
★リンクテーブル★
[★]
- 英
- dexamethasone isonicotinate
