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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/25 22:39:44」(JST)

Deserpidine is an antihypertensive drug related to reserpine.^[1]

References

^ Fulton, S. C.; Healy, M. D. (1976). "Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines". Federation proceedings 35 (14): 2558–2562. PMID 11134. edit

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Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study.

Zhang H1, Zhong D, Zhang Z, Dai X, Chen X.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2009 Oct 1;877(27):3221-5. doi: 10.1016/j.jchromb.2009.06.005. Epub 2009 Jun 10.
A sensitive and rapid liquid chromatography/tandem mass spectrometric (LC/MS/MS) method was developed and validated for the determination of deserpidine in human plasma. The plasma samples were prepared using liquid-liquid extraction (LLE) with ethyl ether-dichloromethane (3:2, v/v). Chromatographic
PMID 19620026

Varchi G1, Battaglia A, Samorì C, Baldelli E, Danieli B, Fontana G, Guerrini A, Bombardelli E.
Journal of natural products.J Nat Prod.2005 Nov;68(11):1629-31.
The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reporte
PMID 16309312

Antibody specificity studies for reserpine, its metabolites, and synthetic reserpine congeners: radioimmunoassay.

Loeffler LJ, Schran HF.
Journal of pharmaceutical sciences.J Pharm Sci.1979 Nov;68(11):1433-5.
Progress in the development of radioimmunoassay techniques for reserpine and related compounds is reported. A conjugate of reserpine with human serum albumin was prepared, involving linkage at the indole nitrogen atom of reserpine. Injection of the purified conjugate into sheep elicited antibodies o
PMID 574544

Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma : Application to a pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(27), 3221-3225, 2009-10-01
NAID 10028025612

インドールアルカロイドの合成研究　ＹｏｈｉｍｂｉｎｅおよびＥｒｇｏｌｉｎｅ系アルカロイドの合成を中心にして:YohimbineおよびErgoline系アルカロイドの合成を中心にして

Photocyclization of Enamides. XXVIII. : A Formal Total Synthesis of (±)-Deserpidine

リンク元

Deserpidine
Identifiers
CAS number	131-01-1
PubChem	8550
ChemSpider	8232
UNII	9016E3VB47
DrugBank	DB01089
KEGG	D08194
ChEBI	CHEBI:27478
ChEMBL	CHEMBL1200515
ATC code	C02AA05
Jmol-3D images	Image 1
	SMILES O=C(OC)[C@H]6[C@H]4C[C@@H]3c2nc1ccccc1c2CCN3C[C@H]4C[C@@H](OC(=O)c5cc(OC)c(OC)c(OC)c5)[C@@H]6OC ;
	InChI InChI=1S/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1 ; Key: CVBMAZKKCSYWQR-WCGOZPBSSA-N InChI=1/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1; Key: CVBMAZKKCSYWQR-WCGOZPBSBL ;
Properties
Molecular formula	C32H38N2O8
Molar mass	578.65 g mol−1
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

Deserpidine

Identifiers
CAS number	131-01-1^Y
PubChem	8550
ChemSpider	8232^Y
UNII	9016E3VB47^Y
DrugBank	DB01089
KEGG	D08194^Y
ChEBI	CHEBI:27478^Y
ChEMBL	CHEMBL1200515^N
ATC code	C02AA05
Jmol-3D images	Image 1
SMILES O=C(OC)[C@H]6[C@H]4C[C@@H]3c2nc1ccccc1c2CCN3C[C@H]4C[C@@H](OC(=O)c5cc(OC)c(OC)c(OC)c5)[C@@H]6OC
InChI InChI=1S/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1^Y Key: CVBMAZKKCSYWQR-WCGOZPBSSA-N^Y InChI=1/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1 Key: CVBMAZKKCSYWQR-WCGOZPBSBL
Properties
Molecular formula	C₃₂H₃₈N₂O₈
Molar mass	578.65 g mol⁻¹
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references