dermatan sulfate

WordNet

1. convert into a sulfate
2. a salt or ester of sulphuric acid (同)sulphate

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/18 00:52:43」(JST)

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Dermatan sulfate

Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	24967-94-0 Y
ATC code	B01AX04 (WHO)
ChemSpider	none
ChEMBL	CHEMBL1909290 N
Chemical data
Formula	C14H21NO15S2
Molar mass	507.43 g·mol−1
NY (what is this?)  (verify)

Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.

It is also referred to as chondroitin sulfate B, although it is no longer classified as a form of chondroitin sulfate by most sources. The formula is C₁₄H₂₁NO₁₅S.

Function

Dermatan sulfate may have roles in coagulation, cardiovascular disease, carcinogenesis, infection, wound repair, and fibrosis.

Pathology

Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.

An excess of dermatan sulfate in the mitral valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, mitral valve prolapse (into the left atrium) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification. Mitral valve insufficiency can lead to eccentric (volume dependent or dilated) hypertrophy and eventually left heart failure if untreated.

See also

• Iduronic acid

References

External links

• Dermatan sulfate at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 2. ムコ多糖症：臨床的特徴および診断 mucopolysaccharidoses clinical features and diagnosis
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English Journal

• Chemical Synthesis of Glycosaminoglycans.

• Mende M1, Bednarek C1, Wawryszyn M1, Sauter P1, Biskup MB2, Schepers U3, Bräse S1,3.
• Chemical reviews.Chem Rev.2016 Jul 13. [Epub ahead of print]
• Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many essential biological cell processes, as well as in many courses of diseases. Because of the potential therapeutic application of GAG polymers, fragments, and also derivatives toward different diseases (e.g., heparin d
• PMID 27410264

• Xyloside-primed Chondroitin Sulfate/Dermatan Sulfate from Breast Carcinoma Cells with a Defined Disaccharide Composition Has Cytotoxic Effects in Vitro.

• Persson A1, Tykesson E2, Westergren-Thorsson G2, Malmström A2, Ellervik U3, Mani K2.
• The Journal of biological chemistry.J Biol Chem.2016 Jul 8;291(28):14871-82. doi: 10.1074/jbc.M116.716829. Epub 2016 May 12.
• We previously reported that the xyloside 2-(6-hydroxynaphthyl) β-d-xylopyranoside (XylNapOH), in contrast to 2-naphthyl β-d-xylopyranoside (XylNap), specifically reduces tumor growth both in vitro and in vivo Although there are indications that this could be mediated by the xyloside-primed glycosa
• PMID 27226567

Japanese Journal

• 生活習慣病患者における血管合併症予防を目指した基礎研究と臨床的実践

• 四国医学雑誌 74(1-2), 37-46, 2018-04-25
• NAID 120006464488

• Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency

• Clinical Biochemistry 50(12), 670-677, 2017-08
• NAID 120006398760

• Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders

• Pharmaceuticals 10(2), 34, 2017-06
• NAID 120006335578

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★リンクテーブル★

リンク元	「デルマタン硫酸」
関連記事	「sulfate」「sulfated」「sulfa」

「デルマタン硫酸」

　　[★]

英

関

同

dermatan sulfate

英

[[]]

同

dermatan sulfate

「sulfate」

　　[★]

• n.

• (官能基やイオンを表して)硫酸、(化合物)硫酸塩、硫酸エステル、硫酸化する

関

H2SO4、inorganic sulfate、sulfate ester、sulfated、sulfation、sulfuric acid、sulfuric acid ester、sulphate、sulphuric acid

　 　

「sulfated」

　　[★]

• adj.

• 硫酸化の

関

sulfate、sulfation、sulphate

「sulfa」

　　[★]

スルファ、サルファ