WordNet

any compound containing a chlorine atom
any salt of hydrochloric acid (containing the chloride ion)

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塩化物

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/27 15:14:52」(JST)

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Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications:

Dequadin an antiseptic and disinfectant. It is a topical bacteriostat. It is used in wound dressings and mouth infections and may also have antifungal action. It may cause skin ulceration.

Fluomizin, vaginal tablets containing 10 mg dequalinium chloride, are used for treating vaginal bacterial conditions (i.e. Bacterial Vaginosis).

The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by a dodecylene chain.

Applications

Dequalinium salts may be used to treat malaria.^[1] As dequalinium chloride, it can be used in lozenges to cure sore throats however while this is effective in vitro, it is not effective in cases of streptococci infections ^[2]

References

^ "US Patent 4946849". United States Patents and Trademarks Office (USPTO). 10 October 1989. Retrieved 2008-03-15.
^ Krämer W. (1977). "[Treatment of tonsilitis with dequalinium chloride]". Fortschr Med. (in German) 95 (16): 1108–10. PMID 856702.

External links

International Mark - Fluomizin(804560)
Medinova Fluomizin
Comparative Study of Efficacy of 10 mg Dequalinium Chloride (Fluomizin) in the Local Treatment of Bacterial Vaginosis

This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
2. 代謝性アルカローシスの臨床症状および評価 clinical manifestations and evaluation of metabolic alkalosis
3. 嚢胞性線維症：臨床症状および診断 cystic fibrosis clinical manifestations and diagnosis
4. 代謝性アルカローシスの病因 pathogenesis of metabolic alkalosis
5. 赤血球水分量の制御 control of red blood cell hydration

English Journal

Raf/MEK/ERK signaling inhibition enhances the ability of dequalinium to induce apoptosis in the human leukemic cell line K562.

Sancho P, Galeano E, Estañ MC, Gañán-Gómez I, Boyano-Adánez Mdel C, García-Pérez AI.SourceDepartamento de Bioquímica y Biología Molecular, Campus Universitario, Universidad de Alcalá, Madrid. pilar.sancho@uah.es
Experimental biology and medicine (Maywood, N.J.).Exp Biol Med (Maywood).2012 Aug 1;237(8):933-42. doi: 10.1258/ebm.2012.011423. Epub 2012 Aug 8.
Delocalized lipophilic cations, such as dequalinium (DQA), selectively accumulate in mitochondria and display anticancer activity in cells from different malignancies. Previous studies in K562 human leukemic cells indicate that DQA causes cell damage as a consequence of an early disturbance in the m
PMID 22875343

Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7.

Chubanov V, Mederos y Schnitzler M, Meißner M, Schäfer S, Abstiens K, Hofmann T, Gudermann T.SourceWalther-Straub-Institute of Pharmacology and Toxicology, University of Munich, Munich, Germany. vladimir.chubanov@lrz.uni-muenchen.de
British journal of pharmacology.Br J Pharmacol.2012 Jun;166(4):1357-76. doi: 10.1111/j.1476-5381.2012.01855.x.
BACKGROUND AND PURPOSE: Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bifunctional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain. TRPM7 is essential for proliferation and cell growth. Up-regulation of TRPM7 function is involve
PMID 22242975

Japanese Journal

Streptococcus sobrinus 6715株接種ラットにおける塩化デカリニウムおよび臭化ドミフェンのう蝕抑制効果

中村康則,桑島治博,木村智彦,青木茂治
歯科基礎医学会雑誌 42(6), 601-608, 2000-12-20
NAID 110003166760

う蝕病原菌の非水溶性グルカン合成に対する第4級アンモニウム塩類の抑制効果

中村康則,桑島治博,木村智彦
歯科基礎医学会雑誌 40(6), 648-655, 1998-12-20
NAID 110003165619

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リンク元	「デカリニウム」
関連記事	「dequalinium」「chloride」

「デカリニウム」

Dequalinium chloride
Names
	IUPAC name 1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) decyl]-2-methyl-4-quinolin-1-iumamine dichloride
Identifiers
ATC code	D08AH01; G01AC05, R02AA02
ChEBI	CHEBI:31466
ChEMBL	ChEMBL333826 ; ChEMBL121663
ChemSpider	2886
DrugBank	DB04209
	InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 ; Key: PCSWXVJAIHCTMO-UHFFFAOYSA-P ; InChI=1/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2; Key: PCSWXVJAIHCTMO-SKRXCDHZAO ;
IUPHAR/BPS	2313
Jmol-3D images	Image
MeSH	Dequalinium
PubChem	10649
	SMILES c12ccccc1c(cc([n+]2CCCCCCCCCC[n+]4c3ccccc3c(N)cc4C)C)N ;
UNII	E7QC7V26B8
Properties
Chemical formula	C30H40Cl2N4
Molar mass	527.58 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references