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Neonatal vaginal irritation results in long-term visceral and somatic hypersensitivity and increased hypothalamic-pituitary-adrenal axis output in female mice.

Pierce AN1, Zhang Z, Fuentes IM, Wang R, Ryals JM, Christianson JA.
Pain.Pain.2015 Oct;156(10):2021-31. doi: 10.1097/j.pain.0000000000000264.
Experiencing early life stress or injury increases a woman's likelihood of developing vulvodynia and concomitant dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To investigate the outcome of neonatal vaginal irritation (NVI), female mouse pups were administered intravaginal zymosan o
PMID 26098441

Changes in VGLUT2 expression and function in pain-related supraspinal regions correlate with the pathogenesis of neuropathic pain in a mouse spared nerve injury model.

Wang ZT1, Yu G2, Wang HS1, Yi SP1, Su RB3, Gong ZH1.
Brain research.Brain Res.2015 Aug 20. pii: S0006-8993(15)00627-7. doi: 10.1016/j.brainres.2015.08.010. [Epub ahead of print]
Vesicular glutamate transporters (VGLUTs) control the storage and release of glutamate, which plays a critical role in pain processing. The VGLUT2 isoform has been found to be densely distributed in the nociceptive pathways in supraspinal regions, and VGLUT2-deficient mice exhibit an attenuation of
PMID 26300222

Dual action of leptin on rest-firing and stimulated catecholamine release via phosphoinositide 3-kinase-driven BK channel up-regulation in mouse chromaffin cells.

Gavello D1,2, Vandael D1,2,3, Gosso S1,2, Carbone E1,2, Carabelli V1,2.
The Journal of physiology.J Physiol.2015 Aug 18. doi: 10.1113/JP271078. [Epub ahead of print]
KEY POINTS: Leptin is an adipokine produced by the adipose tissue regulating body weight through its appetite-suppressing effect and, as such, exerts a relevant action on the adipo-adrenal axis. Leptin has a dual action on adrenal mouse chromaffin cells both at rest and during stimulation. At rest,
PMID 26282459