デオキシリボヌクレアーゼIV
- 関
- endonuclease IV
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- the 9th letter of the Roman alphabet (同)i
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/25 08:48:25」(JST)
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| Deoxyribonuclease IV (phage-T4-induced) |
| Identifiers |
| EC number |
3.1.21.2 |
| CAS number |
63363-78-0 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Deoxyribonuclease IV (phage-T4-induced) (EC 3.1.21.2, endodeoxyribonuclease IV (phage T4-induced), E. coli endonuclease IV, endodeoxyribonuclease, redoxyendonuclease, deoxriboendonuclease, Escherichia coli endonuclease II, endonuclease II, DNA-adenine-transferase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products
Deoxyribonuclease IV is a type of deoxyribonuclease that functions at AP-sites.
References
- ^ Friedberg, E.C.; Goldthwait, D.A. (1969). "Endonuclease II of E. coli. I. Isolation and purification". Proc. Natl. Acad. Sci. USA. 62 (3): 934–940. doi:10.1073/pnas.62.3.934. PMC 223688. PMID 4895219.
- ^ Friedberg, E.C.; Hadi, S.-M.; Goldthwait, D.A. (1969). "Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid". J. Biol. Chem. 244 (21): 5879–5889. PMID 4981786.
- ^ Hadi, S.M.; Goldthwait, D.A. (1971). "Endonuclease II of Escherichia coli. Degradation of partially depurinated deoxyribonucleic acid". Biochemistry. 10 (26): 4986–4993. doi:10.1021/bi00802a024. PMID 4944066.
- ^ Sadowski, P.D.; Hurwitz, J. (1969). "Enzymatic breakage of deoxyribonucleic acid. I. Purification and properties of endonuclease II from T4 phage-infected Escherichia coli". J. Biol. Chem. 244 (22): 6182–6191. PMID 4310836.
See also
External links
- Deoxyriboendonuclease IV at the US National Library of Medicine Medical Subject Headings (MeSH)
- Lindahl T, Gally JA, Edelman GM (1969). "Deoxyribonuclease IV: a new exonuclease from mammalian tissues". Proc. Natl. Acad. Sci. U.S.A. 62 (2): 597–603. doi:10.1073/pnas.62.2.597. PMC 277851. PMID 5256235.
|
Hydrolase: esterases (EC 3.1)
|
|
3.1.1: Carboxylic
ester hydrolases |
- Cholinesterase
- Acetylcholinesterase
- Butyrylcholinesterase
- Pectinesterase
- 6-phosphogluconolactonase
- PAF acetylhydrolase
- Lipase
- Bile salt-dependent
- Gastric/Lingual
- Pancreatic
- Lysosomal
- Hormone-sensitive
- Endothelial
- Hepatic
- Lipoprotein
- Monoacylglycerol
- Diacylglycerol
|
|
| 3.1.2: Thioesterase |
- Palmitoyl protein thioesterase
- Ubiquitin carboxy-terminal hydrolase L1
- 4-hydroxybenzoyl-CoA thioesterase
|
|
| 3.1.3: Phosphatase |
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
|
|
| 3.1.4: Phosphodiesterase |
- Autotaxin
- Phospholipase
- Sphingomyelin phosphodiesterase
- PDE1
- PDE2
- PDE3
- PDE4A/PDE4B
- PDE5
- Lecithinase (Clostridium perfringens alpha toxin)
- Cyclic nucleotide phosphodiesterase
|
|
| 3.1.6: Sulfatase |
- arylsulfatase
- Arylsulfatase A
- Arylsulfatase B
- Arylsulfatase E
- Steroid sulfatase
- Galactosamine-6 sulfatase
- Iduronate-2-sulfatase
- N-acetylglucosamine-6-sulfatase
|
|
Nuclease (includes
deoxyribonuclease and
ribonuclease) |
| 3.1.11-16: Exonuclease |
| Exodeoxyribonuclease |
|
|
| Exoribonuclease |
|
|
|
| 3.1.21-31: Endonuclease |
| Endodeoxyribonuclease |
- Deoxyribonuclease I
- Deoxyribonuclease II
- Deoxyribonuclease IV
- Restriction enzyme
- UvrABC endonuclease
|
|
| Endoribonuclease |
- RNase III
- RNase H
- RNase P
- RNase A
- RNase T1
- RNA-induced silencing complex
|
|
| either deoxy- or ribo- |
- Aspergillus nuclease S1
- Micrococcal nuclease
|
|
|
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Enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
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- 1. 小児における無気肺atelectasis in children [show details]
…patients with severe, uncontrolled bronchospasm or severe airway obstruction. Recombinant human DNase (dornase alfa) was developed for the treatment of cystic fibrosis. Clinical trials have established …
- 2. COPDに気道粘膜作用薬と気道クリアランスが果たす役割role of mucoactive agents and secretion clearance techniques in copd [show details]
… recombinant human DNase is considered a mucokinetic agent that may produce improvement in pulmonary function in patients with clinically stable CF. However, recombinant human DNase does not appear… selected patients with refractory symptoms include systemic antibiotics and thiol preparations (eg,…
- 3. 嚢胞性線維症：肺疾患治療の概要cystic fibrosis overview of the treatment of lung disease [show details]
… cost (DNase costs approximately 30-fold more than hypertonic saline), time required for administration (hypertonic saline is administered twice daily and DNase once daily), tolerability (DNase typically… than those seen in children treated with systemic glucocorticoids. Short-term use of systemic glucocorticoids – Some CF clinicians administer…
- 4. 成人の肺炎随伴胸水と膿胸のマネージメントおよび予後management and prognosis of parapneumonic pleural effusion and empyema in adults [show details]
… plasminogen activator (tPA) with /deoxyribonuclease (DNase). This approach is based upon the high success rate of tPA/DNase treatment which decreases the… we select an empiric IV antibiotic regimen that targets Streptococcus pneumoniae…
- 5. 嚢胞性線維症を有さない小児における気管支拡張症のマネージメントmanagement of bronchiectasis in children without cystic fibrosis [show details]
… For children with non-CF-related bronchiectasis we suggest NOT treating with DNase . Although DNase is recommended for children with CF,… bronchiectasis and include macrolide antibiotics (primarily azithromycin), ibuprofen, and inhaled or systemic glucocorticoids. Little evidence is available to guide their use in pediatric patients with non-CF …
English Journal
- Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
- Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Maiti B, Pique ME, Frankel KA, Hitomi K, Cunningham RP, Mitra S, Tainer JA.SourceLawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
- The Journal of biological chemistry.J Biol Chem.2013 Mar 22;288(12):8445-55. doi: 10.1074/jbc.M112.422774. Epub 2013 Jan 25.
- Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common toxic and mutagenic in vivo DNA lesion. For repair, AP sites must be processed by 5' AP endonucleases in initial stages of base repair. Human APE1 and bacterial Nfo
- PMID 23355472
- 1α,25 dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin.
- Gordon-Thomson C, Gupta R, Tongkao-on W, Ryan A, Halliday GM, Mason RS.SourceDepartment of Physiology, The Bosch Institute, The University of Sydney, NSW 2006, Australia.
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.Photochem Photobiol Sci.2012 Dec;11(12):1837-47. doi: 10.1039/c2pp25202c.
- DNA damage induced by ultraviolet radiation is the key initiator for skin carcinogenesis since mutations may arise from the photoproducts and it also contributes to photoimmune suppression. The active vitamin D hormone, 1α,25 dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) reduces thymine dimers, the major
- PMID 23069805
- A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in vitro recellularization with mesenchymal stem cells.
- Bonvillain RW, Danchuk S, Sullivan DE, Betancourt AM, Semon JA, Eagle ME, Mayeux JP, Gregory AN, Wang G, Townley IK, Borg ZD, Weiss DJ, Bunnell BA.SourceCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
- Tissue engineering. Part A.Tissue Eng Part A.2012 Dec;18(23-24):2437-52. doi: 10.1089/ten.TEA.2011.0594. Epub 2012 Aug 23.
- Currently, patients with end-stage lung disease are limited to lung transplantation as their only treatment option. Unfortunately, the lungs available for transplantation are few. Moreover, transplant recipients require life-long immune suppression to tolerate the transplanted lung. A promising alte
- PMID 22764775
Japanese Journal
- ヒト子宮内膜間質細胞in vitro培養系を用いた, 各種プロゲストーゲンの脱落膜化誘起活性の評価
- 慢性関節リウマチ関節液中の酸性ＤＮＡ分解酵素について （第一報）
Related Links
- Definitions of Deoxyribonuclease IV, synonyms, antonyms, derivatives of Deoxyribonuclease IV, analogical dictionary of Deoxyribonuclease IV (English) ...
- Learn and talk about Deoxyribonuclease IV , and check out Deoxyribonuclease IV on Wikipedia, Youtube, Google News, Google Books ...
★リンクテーブル★
[★]
- 英
- deoxyribonuclease IV
- 関
- エンドヌクレアーゼIV
[★]
エンドヌクレアーゼIV
- 関
- deoxyribonuclease IV
[★]
[★]
デオキシリボヌクレアーゼ、DNA分解酵素
- 関
- desoxyribonuclease、DNA nuclease、DNAase、DNase
- 同
- dornase
[★]
- 関
- i.v.、intravascular、intravenous、intravenously