WordNet

a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) (同)base

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Jonna VR1, Crona M2, Rofougaran R1, Lundin D2, Johansson S1, Brännström K1, Sjöberg BM2, Hofer A3.
The Journal of biological chemistry.J Biol Chem.2015 Jul 10;290(28):17339-48. doi: 10.1074/jbc.M115.649624. Epub 2015 May 13.
Ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to the corresponding deoxyribonucleotides, which are used as building blocks for DNA replication and repair. This process is tightly regulated via two allosteric sites, the specificity site (s-site) and the overall activity si
PMID 25971975

β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A1 receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum.

Wang GD1, Wang XY1, Liu S1, Xia Y2, Zou F1, Qu M1, Needleman BJ3, Mikami DJ3, Wood JD1.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2015 Jun 1;308(11):G955-63. doi: 10.1152/ajpgi.00430.2014. Epub 2015 Mar 26.
Intracellular microelectrodes were used to record neurogenic inhibitory junction potentials in the intestinal circular muscle coat. Electrical field stimulation was used to stimulate intramural neurons and evoke contraction of the smooth musculature. Exposure to β-nicotinamide adenine dinucleotide
PMID 25813057

Zhang D1, Gao ZG2, Zhang K1, Kiselev E2, Crane S2, Wang J1, Paoletta S2, Yi C1, Ma L1, Zhang W1, Han GW3, Liu H1, Cherezov V3, Katritch V4, Jiang H5, Stevens RC6, Jacobson KA2, Zhao Q1, Wu B1.
Nature.Nature.2015 Apr 16;520(7547):317-21. doi: 10.1038/nature14287. Epub 2015 Mar 30.
In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human P2Y1R in complex with a nucleotide antagonist MRS2500 at 2.7 Å resolution, and with a n
PMID 25822790