demethylate

• 脱メチルする、脱メチル化する

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demethyl、demethylation、desmethyl

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/17 05:13:23」(JST)

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Demethylating agents are compounds that can inhibit methylation, resulting in the expression of the previously hypermethylated silenced genes (see methylation: methylation and cancer for more detail). Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (decitabine) are the most commonly used demethylating agents . These compounds work by binding to the enzymes that catalyse the methylation reaction, DNA methyltransferases; and titrate out these enzymes. Both compounds have been approved in the treatment of Myelodysplastic syndrome (MDS) by Food and Drug Administration (FDA) in United States. Azacitidine and decitabine are marketed as Vidaza and Dacogen respectively. Azacitidine is the first drug to be approved by FDA for treating MDS and has been given orphan drug status. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.

References

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• 1. 成人における単極性うつ病と三環系抗うつ剤および四環系抗うつ剤：薬理学、投与、
  および副作用 unipolar depression in adults and tricyclic and tetracyclic drugs pharmacology administration and side effects

English Journal

• Aldosterone reprograms promoter methylation to regulate αENaC transcription in the collecting cuct.

• Yu Z, Kong Q, Kone BC.SourceDiv. of Renal Diseases and Hypertension, The Univ. of Texas Medical School at Houston, 6431 Fannin, MSB 5.124, Houston, TX 77030. Bruce.C.Kone@uth.tmc.edu.
• American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Oct;305(7):F1006-F1013. Epub 2013 Aug 7.
• Aldosterone increases tubular Na+ absorption largely by increasing α-epithelial Na+ channel (αENaC) transcription in collecting duct principal cells. How aldosterone reprograms basal αENaC transcription to high-level activity in the collecting duct is incompletely understood. Promoter methylation
• PMID 23926181

• Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors.

• Huisman C, Wisman GB, Kazemier HG, van Vugt MA, van der Zee AG, Schuuring E, Rots MG.SourceDept. of Pathology and Medical Biology, University Medical Centre Groningen (UMCG), University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. c.huisman@umcg.nl
• Molecular oncology.Mol Oncol.2013 Jun;7(3):669-79. doi: 10.1016/j.molonc.2013.02.017. Epub 2013 Mar 5.
• C13ORF18 is frequently hypermethylated in cervical cancer but not in normal cervix and might serve as a biomarker for the early detection of cervical cancer in scrapings. As hypermethylation is often observed for silenced tumor suppressor genes (TSGs), hypermethylated biomarker genes might exhibit t
• PMID 23522960

• Bacterial metabolism of environmental arsenic--mechanisms and biotechnological applications.

• Kruger MC, Bertin PN, Heipieper HJ, Arsène-Ploetze F.SourceDepartment of Environmental Biotechnology, Helmholtz Centre for Environmental Research-UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
• Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2013 May;97(9):3827-41. doi: 10.1007/s00253-013-4838-5. Epub 2013 Apr 2.
• Arsenic causes threats for environmental and human health in numerous places around the world mainly due to its carcinogenic potential at low doses. Removing arsenic from contaminated sites is hampered by the occurrence of several oxidation states with different physicochemical properties. The actua
• PMID 23546422

Japanese Journal

• Biodegradation of Vanillate Derivatives by White-Rot Fungus, Phlebia Radiata

• Cho Nam-Seok,Rogalski Jerzy,Cho Hee-Yeon,Shin Soo-Jeong,Ohga Shoji,大賀 祥治
• Journal of the Faculty of Agriculture, Kyushu University 54(2), 293-296, 2009-10-29
• … These enzymes can demethylate monomeric and polymeric structures as well as cleave the aromatic ring. …
• NAID 120001766550

• Regioselective Bioconversion of Colchicine and Thiocolchicine into Their Corresponding 3-Demethyl Derivatives

• POULEV ALEXANDER,BOMBARDELLI EZIO,PONZONE CESARE,ZENK MEINHART H.
• Journal of fermentation and bioengineering 79(1), 33-38, 1995-01-25
• … A variety of plant cell cultures and microbial soil isolates were screened for their ability to specifically demethylate colchicine at the C-3 position. … Among all plant cell cultures tested, the newly established Colchicum veriegatum culture was the only one able to demethylate colchicine, however unspecifically, yielding a mixture of 3-demethylcolchicine and 2-demethylcolchine. …
• NAID 110002691589

Related Links

• Demethylate - Merriam-Webster Online

Definition of demethylate from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games.

• demethylate - Wiktionary

demethylate (third-person singular simple present demethylates, present participle demethylating, simple past and past participle demethylated). ( chemistry) To remove one or more methyl groups from a molecule, especially from a biologically ...

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リンク元	「脱メチル化」「脱メチル」「demethylation」「desmethyl」「demethyl」

「脱メチル化」

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英

demethylation、desmethyl、demethylate

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脱メチル、脱メチル体

「脱メチル」

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英

demethylation、demethyl、demethylate

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脱メチル化、デメチル

「demethylation」

　　[★]

• 脱メチル、脱メチル化

関

demethyl、demethylate、desmethyl

「desmethyl」

　　[★]

脱メチル化、脱メチル体

関

demethylate、demethylation

「demethyl」

　　[★]

脱メチル、デメチル

関

demethylate、demethylation