WordNet

act later than planned, scheduled, or required; "Dont delay your application to graduate school or else it wont be considered"
time during which some action is awaited; "instant replay caused too long a delay"; "he ordered a hold in the action" (同)hold, time_lag, postponement, wait
the act of delaying; inactivity resulting in something being put off until a later time (同)holdup
cause to be slowed down or delayed; "Traffic was delayed by the bad weather"; "she delayed the work that she didnt want to perform" (同)detain, hold_up
not as far along as normal in development

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1. カテコラミン誘発多形性心室頻拍および他のQT間隔正常の多形性心室頻拍 catecholaminergic polymorphic ventricular tachycardia and other polymorphic ventricular tachycardias with a normal qt interval
2. ジゴキシン中毒による不整脈 cardiac arrhythmias due to digoxin toxicity
3. 限局性心房性頻拍 focal atrial tachycardia
4. 心不全および心筋症における心室性不整脈の病因 pathogenesis of ventricular arrhythmias in heart failure and cardiomyopathy
5. 先天性および後天性ＱＴ延長症候群の遺伝学 genetics of congenital and acquired long qt syndrome

Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue.

Liu MB1, de Lange E2, Garfinkel A3, Weiss JN4, Qu Z5.
Heart rhythm : the official journal of the Heart Rhythm Society.Heart Rhythm.2015 Oct;12(10):2115-24. doi: 10.1016/j.hrthm.2015.06.019. Epub 2015 Jun 10.
BACKGROUND: Delayed afterdepolarizations (DADs) have been well characterized as arrhythmia triggers, but their role in generating a tissue substrate vulnerable to reentry is not well understood.OBJECTIVE: The purpose of this study was to test the hypothesis that random DADs can self-organize to gene
PMID 26072025

Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load.

Campos FO1, Shiferaw Y2, Prassl AJ1, Boyle PM3, Vigmond EJ4, Plank G5.
Cardiovascular research.Cardiovasc Res.2015 Jul 1;107(1):175-83. doi: 10.1093/cvr/cvv149. Epub 2015 May 12.
AIMS: Premature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains incompletely understood. The aim of this study was to investigate the cond
PMID 25969391

Effect of myofilament Ca(2+) sensitivity on Ca(2+) wave propagation in rat ventricular muscle.

Miura M1, Taguchi Y2, Nagano T2, Sasaki M2, Handoh T2, Shindoh C2.
Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2015 Jul;84:162-9. doi: 10.1016/j.yjmcc.2015.04.027. Epub 2015 May 4.
BACKGROUND: The propagation velocity of Ca(2+) waves determines delayed afterdepolarization and affects the occurrence of triggered arrhythmias in cardiac muscle. We focused on myofilament Ca(2+) sensitivity, investigating how the velocity of Ca(2+) waves responds to its increased sensitivity result
PMID 25953256

Mutation-linked defective inter-domain interactions within ryanodine receptor as a pathogenic mechanism of catecholaminergic polymorphic ventricular tachycardia

Suetomi Takeshi,Yano Masafumi,Matsuzaki Masunori
The bulletin of the Yamaguchi Medical School 59(3-4), 25-29, 2012
… A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. …
NAID 120005198529

武下大毅,嶋吉隆夫,松田哲也
情報処理学会研究報告. BIO, バイオ情報学 2011-BIO-27(18), 1-6, 2011-11-24
重大な心臓病態の一つに不整脈がある.特に薬剤投与の副作用による不整脈の発生は大きな問題となっており,未然に副作用の危険性を調べることは重要である.従来では危険性を調べるために動物実験を行われてきたが,近年ではコンピュータシミュレーションにより,比較的低コストで効率的にデータを得ることが有効な手段となっている.本稿では,心筋細胞モデルにパラメタ変化を加えたシミュレーションにより,不整脈の一原因である …
NAID 110008694780

武下大毅,嶋吉隆夫,松田哲也
情報処理学会研究報告. MPS, 数理モデル化と問題解決研究報告 2011-MPS-86(18), 1-6, 2011-11-24
重大な心臓病態の一つに不整脈がある.特に薬剤投与の副作用による不整脈の発生は大きな問題となっており,未然に副作用の危険性を調べることは重要である.従来では危険性を調べるために動物実験を行われてきたが,近年ではコンピュータシミュレーションにより,比較的低コストで効率的にデータを得ることが有効な手段となっている.本稿では,心筋細胞モデルにパラメタ変化を加えたシミュレーションにより,不整脈の一原因である …
NAID 110008694721