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English Journal

Inhibitors of mTOR overcome drug resistance from topoisomerase II inhibitors in solid tumors.

Gaur S, Chen L, Yang L, Wu X, Un F, Yen Y.SourceDepartment of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, United States.
Cancer letters.Cancer Lett.2011 Dec 1;311(1):20-8. Epub 2011 Jun 29.
The present study was performed to investigate the possible role of mTOR inhibitors in restoring chemosensitivity to adriamycin/cisplatin and elucidate the underlying mechanism. Combining adriamycin/cisplatin with torisel synergistically inhibited the cell proliferation in human oropharyngeal carcin
PMID 21764510

Effects of Heavy Metals and Pesticides on Buffalo (Bubalus bubalis) Spermatozoa Functions In Vitro.

Selvaraju S, Nandi S, Gupta P, Ravindra J.SourceAnimal Physiology Division, National Institute of Animal Nutrition and Physiology, Adugodi, Bangalore, India.
Reproduction in domestic animals = Zuchthygiene.Reprod Domest Anim.2011 Oct;46(5):807-13. doi: 10.1111/j.1439-0531.2010.01745.x. Epub 2011 Jan 17.
Industrial toxic metals, pollutants and bio-accumulative pesticides interfere with the male reproductive functions in farm animals. Frozen-thawed semen samples were incubated with heavy metals (cadmium and lead) and pesticides (chlorpyrifos and endosulfan) of different concentrations (0, 0.005, 0.05
PMID 21241381

Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET

Shaheen Sharif M.,Akita Hidetaka,Yamashita Atsushi,Katoono Ryo,Yui Nobuhiko,Biju Vasudevanpillai,Ishikawa Mitsuru,Harashima Hideyoshi
Nucleic Acids Research 39(7), e48, 2011-04
… Recent studies indicate that controlling the nuclear decondensation and intra-nuclear localization of plasmid DNA (pDNA) would result in an increased transfection efficiency. … In the present study, we established a technology for imaging the nuclear condensation/decondensation status of pDNA in nuclear subdomains using fluorescence resonance energy transfer (FRET) between quantum dot (QD)-labeled pDNA as donor, and rhodamine-labeled polycations as acceptor. …
NAID 120002989236

Sperm of the wasted mutant are wasted when females utilize the stored sperm in Drosophila melanogaster

Ohsako Takashi,Yamamoto Masa-Toshi
Genes & Genetic Systems 86(2), 97-108, 2011
… Furthermore, wst sperm fail to undergo nuclear decondensation, which prevents the process of fertilization even when sperm enter eggs. …
NAID 130000758287