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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/12/29 20:50:04」(JST)

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  • Update on the pharmacotherapy for myelodysplastic syndromes.
  • Duong VH1, Komrokji RS, List AF.
  • Expert opinion on pharmacotherapy.Expert Opin Pharmacother.2014 Sep;15(13):1811-25. doi: 10.1517/14656566.2014.937705. Epub 2014 Jul 31.
  • INTRODUCTION: For many decades, myelodysplastic syndromes (MDS) were a poorly understood disease group with no approved therapies, and patient management largely relied upon supportive care and intensive chemotherapy. The last decade has seen many scientific and therapeutic advances culminating in t
  • PMID 25080144
  • Decitabine reduces transfusion dependence in older patients with acute myeloid leukaemia: results from a post-hoc analysis of a RANDOMISED Phase III study.
  • He J, Xiu L, De Porre P, Dass R, Thomas X.
  • Leukemia & lymphoma.Leuk Lymphoma.2014 Aug 7:1-22. [Epub ahead of print]
  • ABSTRACT This post-hoc analysis of the DACO-016 Phase III study evaluates the impact of decitabine on transfusion dependence and survival in 485 elderly patients with newly diagnosed acute myeloid leukemia (AML). Red blood cell (RBC) and platelet (PLT) transfusion independence, defined as no transfu
  • PMID 25098427
  • Epigenetic drugs against cancer: an evolving landscape.
  • Di Costanzo A1, Del Gaudio N, Migliaccio A, Altucci L.
  • Archives of toxicology.Arch Toxicol.2014 Aug 2. [Epub ahead of print]
  • Alteration of the chromatin orchestra seems to play a critical role in cancer. In recent years, in-depth studies of epigenetic machinery and its deregulation have led to the development and use of a wide range of modulatory molecules directed not only at chromatin enzymes (histone acetyltransferases
  • PMID 25085708


  • Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells
  • Ueda Kumiko,Hosokawa Mika,Iwakawa Seigo
  • Biological and Pharmaceutical Bulletin 38(8), 1113-1119, 2015
  • Decitabine (DAC), a DNA methyltransferase 1 inhibitor of nucleoside analogues, has been shown to restore gene expression silenced by hypermethylation. …
  • NAID 130005090657
  • Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells
  • Tanaka Shota,Hosokawa Mika,Ueda Kumiko,Iwakawa Seigo
  • Biological and Pharmaceutical Bulletin advpub(0), 2015
  • … The effects of decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, on metastasis and exosomal expression of microRNAs were examined in SW620/OxR cells, a human colorectal cancer (CRC) cell line (SW620) with acquired resistance to oxaliplatin. …
  • NAID 130005088147
  • Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B
  • Itonaga Hidehiro,Imanishi Daisuke,Wong Yan-Fung,Sato Shinya,Ando Koji,Sawayama Yasushi,Sasaki Daisuke,Tsuruda Kazuto,Hasegawa Hiroo,Imaizumi Yoshitaka,Taguchi Jun,Tsushima Hideki,Yoshida Shinichiro,Fukushima Takuya,Hata Tomoko,Moriuchi Yukiyoshi,Yanagihara Katsunori,Miyazaki Yasushi
  • Leukemia 28(7), 1459-1466, 2014-07
  • … DNA methyltransferase inhibitors (decitabine and zeburaline) induced MPO gene promoter demethylation and MPO gene transcription in AML cells with low MPO activity. …
  • NAID 120005477053


decitabine PubMed検索 臨床試験(ランダム化比較試験) 臨床試験(その他) 臨床試験以外の研究 ClinicalTrials.gov検索 登録・公開されている臨床試験 がん情報サービス 公的会議で取り上げられた国内未承認薬の情報:http ...
日本人の骨髄異形成症候群(MDS)患者を対象とするDNAメチル化阻害剤decitabineのフェーズ1/2試験がThe Japanese Decitabine Study Groupによって行われ、結果が10月14日から16日まで名古屋市で開催された第73回日本血液学会学術集会で発表 ...


 the Launch of Decitabine for InjectionBuy Decitabine | DNA Methyltransferase Decitabine - Arbor Assays _ P015-10MG decitabine 30 05 2014 decitabine is a Structures of 5-azacytidine (azacitidine Decitabine.svg