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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/29 20:00:44」(JST)

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Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent,^[1] and is used in anesthesia to induce paralysis.

Pharmacology

Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate - but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

Contraindications/limitations

Decamethonium does not produce unconsciousness or anesthesia, and its effects may cause considerable psychological distress while simultaneously making it impossible for a patient to communicate. For these reasons, administration of the drug to a conscious patient is strongly advised against, except in necessary emergency situations.

Decamethonium was used clinically in the UK for many years, but it is now available only for research purposes.

References

^ Lee C, Jones T (May 2002). "Molecular conformation-activity relationship of decamethonium congeners". Br J Anaesth 88 (5): 692–9. doi:10.1093/bja/88.5.692. PMID 12067008.

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

English Journal

Competition between covalent and noncovalent bond cleavages in dissociation of phosphopeptide-amine complexes.

Laskin J, Yang Z, Woods AS.SourcePacific Northwest National Laboratory, Chemical and Materials Sciences Division, P.O. Box 999, K8-88, Richland, Washington 99352, USA. Julia.Laskin@pnl.gov
Physical chemistry chemical physics : PCCP.Phys Chem Chem Phys.2011 Apr 21;13(15):6936-46. Epub 2011 Mar 8.
Interactions between quaternary amino or guanidino groups with anions are ubiquitous in nature and have been extensively studied phenomenologically. However, little is known about the binding energies in non-covalent complexes containing these functional groups. Here, we present a first study focuse
PMID 21387029

Mechanical influences on morphogenesis of the knee joint revealed through morphological, molecular and computational analysis of immobilised embryos.

Roddy KA, Prendergast PJ, Murphy P.SourceDepartment of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin, Ireland.
PloS one.PLoS One.2011 Feb 28;6(2):e17526.
Very little is known about the regulation of morphogenesis in synovial joints. Mechanical forces generated from muscle contractions are required for normal development of several aspects of normal skeletogenesis. Here we show that biophysical stimuli generated by muscle contractions impact multiple
PMID 21386908

Japanese Journal

Interaction of decamethonium with hexamethonium or vecuronium in the rat : an isobolographic analysis

REDAI I
Anesth Analg 81, 768-772, 1995
NAID 30012752542

The Structure-Activity Relationship between Phenylene-polymethylene Bis-ammonium Derivatives and Their Neuromuscular Blocking Action on Mouse Phrenic Nerve-Diaphragm Muscle

木村正康,木村郁子,室井正志,田中克尚,野島浩史,上野照子,小泉徹
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17(9), 1224-1231, 1994-09-15
… A PMBA composed of X=CH_2,n=5 and R=N^+Et_3 was 5.9- and 23-fold more potent than SuCh and decamethonium, respectively. …
NAID 110003666194

Succinylcholine-Induced Acceleration and Suppression of Electrically Evoked Acetylcholine Release from Mouse Phrenic Nerve-Hemidiaphragm Muscle Preparation.

Kimura Ikuko,Okazaki Mari,Uwano Teruko,Kobayashi Shinjiro,Kimura Masayasu
The Japanese Journal of Pharmacology 57(3), 397-403, 1991
… Decamethonium even at 10 and 30 μM had little effect on [<SUP>3</SUP>H]-ACh release despite producing a significantly greater reduction in tension compared with succinylcholine. …
NAID 130000833243

Related Pictures

★リンクテーブル★

リンク元	「薬理学」「神経筋接合部」「脱分極性筋弛緩薬」「脱分極性遮断薬」「C10」
拡張検索	「decamethonium compound」

「薬理学」

Decamethonium
Systematic (IUPAC) name
	trimethyl-(10-trimethylammoniodecyl)ammonium
Identifiers
CAS Registry Number	156-74-1
ATC code	None
PubChem	CID: 10921
DrugBank	DB01245
ChemSpider	10459
UNII	C1CG1S3T2W
ChEBI	CHEBI:41934
ChEMBL	CHEMBL1134
Chemical data
Formula	C16H38N2
Molecular mass	258.486 g/mol
	SMILES [Br-].[Br-].C(CCCC[N+](C)(C)C)CCCCC[N+](C)(C)C ;
	InChI InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2 ; Key:HLXQFVXURMXRPU-UHFFFAOYSA-L ;
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　　[★]

英: pharmacology
関: drug entries

定義

生物系と化学物質の選択的な相互作用を研究する学問 (SPC.2)

生物系と薬の相互作用

薬の生物系に対する相互作用：薬理作用 <-化学の視点
生物系の薬に対する相互作用：薬物動態 <-生物の視点

薬品の命名

Ending of the drug name	Category	Example
～afil	Erectile dysfunction	sildenafil
～ane	Inhalatinal general anesthetic	halothane
～azepam	Benzodiaizepine	diazepam
～azine	Phenothiazine (neuroleptic, antiemetic)	chlorpromazine
～azole	Ailtifungal	ketoconazole
～barbital	Barbiturate	phenobarbital
～caine	Local anesthetic	lidocaine
～cillin	Penicillin	methicillin
～cycline	Antibiotic, protein syntlesis inhibitor	tetracycline
～ipramine	TCA	iimipramine
～navir	Protease inhibitor	saquinavir
～olol	β-antagonist	propranolol
～operidol	Butyrophenone ( neuroleptic )	haloperidol
～oxin	Cardiac glycoside ( inotropic agent )	digoxin
～phylline	Methylxanthine	theophylline
～pril	ACE inhibitor	captopril
～terol	β₂ agonist	albuterol
～tidine	H₂ antagonist	cimtidine
～triptyline	TCA	amitriptyline
～tropine	Pituitary hormone	somatotropine
～zosin	a₁ antagonist	prazosin

薬一覧

薬物代謝

薬理動態

神経伝達物質

貧血治療薬

甲状腺関連物質

甲状腺ホルモン製剤

レボチロキシン levothyroxine
リオチニシン liothyronine

抗甲状腺薬

痛風治療薬

痛風発作予防薬

コルヒチン colchicine

尿酸排泄促進薬

尿酸生成抑制薬

アロプリノール allopurinol

「神経筋接合部」

　　[★]

英: neuromuscular junction (K)
同: 神経筋シナプス neuromuscular synapse

神経筋接合部は軸索終末，シナプス間隙，筋細胞膜から構成される。

神経筋接合部に作用する薬物 (GPC.225)

	＋	－
神経活動電位発生		tetrodotoxin
神経活動電位発生		batrachotoxin
アセチルコリン放出	excess of Ca2+	hemicholinium
		botulinus toxin
		procaine
		Mg2+
		4-aminopyridine
		lack of Ca2+
終板電位発生	succinylcholine(suxamethonium)	curare alkaloids
終板電位発生	decamethonium	α-toxins
アセチルコリン加水分解	cholinesterase inhibitors
筋活動電位発生	veratridine	quinine
筋活動電位発生	veratridine	tetrodotoxin
筋収縮		procaine
筋収縮		dantrolene