- 関
- death domain receptor、DR
WordNet
- the time when something ends; "it was the death of all his plans"; "a dying of old hopes" (同)dying, demise
- the time at which life ends; continuing until dead; "she stayed until his death"; "a struggle to the last" (同)last
- the absence of life or state of being dead; "he seemed more content in death than he had ever been in life"
- the permanent end of all life functions in an organism or part of an organism; "the animal died a painful death"
- the act of killing; "he had two deaths on his conscience"
- the event of dying or departure from life; "her death came as a terrible shock"; "upon your decease the capital will pass to your grandchildren" (同)decease, expiry
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the personification of death; "Death walked the streets of the plague-bound city"
PrepTutorEJDIC
- 〈U〉〈C〉『死』,死亡;死に方,死にざま / 〈U〉死んだ[ような]状体 / 《the~》(…の)絶滅,破滅《+『of』+『名』》 / 《the~》(…の)死の原因,命取り《+『of』+『名』》 / 《通例『D-』》死神(手に鎌(かマ)を持った黒装束の骸骨(がいこつ)で表される)
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/30 00:51:00」(JST)
[Wiki en表示]
| TNFR/NGFR cysteine-rich region |
|
Structure of the soluble human 55 kd TNF receptor-human TNF beta complex.[1]
|
| Identifiers |
| Symbol |
TNFR_c6 |
| Pfam |
PF00020 |
| InterPro |
IPR011614 |
| PROSITE |
PDOC00561 |
| SCOP |
1tnr |
| SUPERFAMILY |
1tnr |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.[2][3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha.[4] In their active form, the majority of TNF receptors form trimeric complexes in the plasma membrane. Accordingly, most TNF receptors contain transmembrane domains (TMDs), although some can be cleaved into soluble forms (e.g. TNFR1), and some lack a TMD entirely (e.g. DcR3). In addition, most TNF receptors require specific adaptor protein such as TRADD, TRAF, RIP and FADD for downstream signalling. TNF receptors are primarily involved in apoptosis and inflammation, but they can also take part in other signal transduction pathways, such as proliferation, survival, and differentiation. TNF receptors are expressed in a wide variety of tissues in mammals, especially in leukocytes.[4]
The term death receptor refers to those members of the TNF receptor superfamily that contain a death domain, such as TNFR1, Fas receptor, DR4 and DR5.[4] They were named after the fact that they seemed to play an important role in apoptosis (programmed cell death), although they are now known to play other roles as well.[5]
In the strict sense, the term TNF receptor is often used to refer to the archetypal members of the superfamily, namely TNFR1 and TNFR2, which recognize TNF-alpha.
Contents
- 1 Members
- 2 References
- 3 Further reading
- 4 External links
Members
There are 27 family members, numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter.[2]
| Type |
Protein (member #) |
Synonyms |
Gene |
Ligand(s) |
| 1 |
Tumor necrosis factor receptor 1 (1A) |
CD120a |
TNFRSF1A |
TNF-alpha (cachectin) |
| Tumor necrosis factor receptor 2 (1B) |
CD120b |
TNFRSF1B |
| 3 |
Lymphotoxin beta receptor (3) |
CD18 |
LTBR |
Lymphotoxin beta (TNF-C) |
| 4 |
OX40 (4) |
CD134 |
TNFRSF4 |
OX40L |
| 5 |
CD40 (5) |
Bp50 |
CD40 |
CD154 |
| 6 |
Fas receptor (6) |
Apo-1, CD95 |
FAS |
FasL |
| Decoy receptor 3 (6B) |
TR6, M68 |
TNFRSF6B |
FasL, LIGHT, TL1A |
| 7 |
CD27 (7) |
S152, Tp55 |
CD27 |
CD70, Siva |
| 8 |
CD30 (8) |
Ki-1 |
TNFRSF8 |
CD153 |
| 9 |
4-1BB (9) |
CD137 |
TNFRSF9 |
4-1BB ligand |
| 10 |
Death receptor 4 (10A) |
TRAILR1, Apo-2, CD261 |
TNFRSF10A |
TRAIL |
| Death receptor 5 (10B) |
TRAILR2, CD262 |
TNFRSF10B |
| Decoy receptor 1 (10C) |
TRAILR3, LIT, TRID, CD263 |
TNFRSF10C |
| Decoy receptor 2 (10D) |
TRAILR4, TRUNDD, CD264 |
TNFRSF10D |
| 11 |
RANK (11A) |
CD265 |
TNFRSF11A |
RANKL |
| Osteoprotegerin (11B) |
OCIF, TR1 |
TNFRSF11B |
| 12 |
TWEAK receptor (12A) |
Fn14, CD266 |
TNFRSF12A |
TWEAK |
| 13 |
TACI (13B) |
IGAD2, CD267 |
TNFRSF13B |
APRIL, BAFF, CAMLG |
| BAFF receptor (13C) |
CD268 |
TNFRSF13C |
BAFF |
| 14 |
Herpesvirus entry mediator (14) |
ATAR, TR2, CD270 |
TNFRSF14 |
LIGHT |
| 16 |
Nerve growth factor receptor (16) |
p75NTR, CD271 |
NGFR |
NGF, BDNF, NT-3, NT-4 |
| 17 |
B-cell maturation antigen (17) |
TNFRSF13A, CD269 |
TNFRSF17 |
BAFF |
| 18 |
Glucocorticoid-induced TNFR-related (18) |
AITR, CD357 |
TNFRSF18 |
GITR ligand |
| 19 |
TROY (19) |
TAJ, TRADE |
TNFRSF19 |
unknown |
| 21 |
Death receptor 6 (21) |
CD358 |
TNFRSF21 |
| 25 |
Death receptor 3 (25) |
Apo-3, TRAMP, LARD, WS-1 |
TNFRSF25 |
TL1A |
| 27 |
Ectodysplasin A2 receptor (27) |
XEDAR |
EDA2R |
EDA-A2 |
References
- ^ Banner DW, D'Arcy A, Janes W, et al. (May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell. 73 (3): 431–45. PMID 8387891. doi:10.1016/0092-8674(93)90132-A.
- ^ a b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell. 104 (4): 487–501. PMID 11239407. doi:10.1016/S0092-8674(01)00237-9.
- ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology. 115 (1): 1–20. PMC 1782125 . PMID 15819693. doi:10.1111/j.1365-2567.2005.02143.x.
- ^ a b c Gravestein, LA; Borst, J (December 1998). "Tumor necrosis factor receptor family members in the immune system.". Seminars in immunology. 10 (6): 423–34. PMID 9826575. doi:10.1006/smim.1998.0144.
- ^ Ashkenazi, A.; Dixit, VM (1998). "Death Receptors: Signaling and Modulation". Science. 281 (5381): 1305–8. PMID 9721089. doi:10.1126/science.281.5381.1305.
Further reading
- Kavurma MM, Tan NY, Bennett MR (2008). "Death receptors and their ligands in atherosclerosis". Arterioscler Thromb Vasc Biol. 28 (10): 1694–702. PMID 18669890. doi:10.1161/ATVBAHA.107.155143.
- Hatano, E. (2007). "Tumor necrosis factor signaling in hepatocyte apoptosis". J Gastroenterol Hepatol. 22: S43–44. PMID 17567463. doi:10.1111/j.1440-1746.2006.04645.x.
External links
- Tumor Necrosis Factor Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Membrane proteins, receptors: cell surface receptors
|
| G protein–coupled receptor |
| Class A |
- Eicosanoid receptor (Prostaglandin receptor)
- Protease-activated receptor
- Neurotransmitter receptor
- Purinergic receptor
- Biogenic amine receptor
- Olfactory receptor
|
| Class B |
|
| Class C |
- Metabotropic glutamate receptor
|
| Class D |
|
| Class E |
|
| Class F |
|
|
| Ligand-gated ion channel |
|
| Enzyme-linked receptor |
- Serine/threonine-specific protein kinase
- Receptor tyrosine kinase
- Guanylate cyclase
|
| Other/ungrouped |
- Asialoglycoprotein receptor
- Tumor necrosis factor receptor
- Immunoglobulin superfamily
- N-Acetylglucosamine receptor
- Neuropilins
- Transferrin receptor
- EDAR
- Lipoprotein receptor-related protein
- Progestin and adipoQ receptor
|
|
Cytokine receptors
|
Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
|
| Other |
|
|
| TNF receptor |
| 1-10 |
- TNFR1 (TNFRSF1A)
- TNFR2 (TNFRSF1B)
- LTBR (TNFRSF3)
- CD134 (TNFRSF4)
- CD40 (TNFRSF5)
- Fas receptor (TNFRSF6)
- DcR3 (TNFRSF6B)
- CD27 (TNFRSF7)
- CD30 (TNFRSF8)
- CD137 (TNFRSF9)
|
| 11-20 |
- DR4 (TNFRSF10A)
- DR5 (TNFRSF10B)
- DcR1 (TNFRSF10C)
- DcR2 (TNFRSF10D)
- RANK (TNFRSF11A)
- Osteoprotegerin (TNFRSF11B)
- TweakR (TNFRSF12A)
- TACI (TNFRSF13B)
- BAFFR (TNFRSF13C)
- HVEM (TNFRSF14)
- NGFR (TNFRSF16)
- BCMA (TNFRSF17)
- GITR (TNFRSF18)
- TAJ/TROY (TNFRSF19)
|
| 21-27 |
- DR6 (TNFRSF21)
- DR3 (TNFRSF25)
- EDA2R (TNFRSF27)
|
|
| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
|
| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
|
| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
|
| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
|
| Other |
- hormone receptor: GH
- prolactin
|
|
| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
|
|
| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
|
| IL 17 family |
- IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
| S/T |
|
|
Apoptosis signaling pathway
|
| Fas path |
|
Ligand
|
|
|
Receptor
|
|
|
Intracellular
|
- Death-inducing signaling complex
- Cytochrome c
- Caspase 9
- Caspase 3
- Pro-apoptotic:
- BAX
- BAK1/Bcl-2 homologous antagonist killer
- Bcl-2-associated death promoter
- Anti-apoptotic:
- Bcl-2
- Bcl-xL
|
|
| TNF path |
|
Ligand
|
- Tumor necrosis factor alpha
|
|
Receptor
|
- Tumor necrosis factor receptor 1
- Tumor necrosis factor receptor 2
|
|
Intracellular
|
- FADD
- Caspase 8
- Caspase 3
- BID
- TRAF2
- ASK-1
- MEKK1
- IKK
- IκBα
- MKK7
- JNK
- NF-κB
|
|
| Other |
|
Intracellular
|
- IAPs
- XIAP
- NAIP
- Survivin
- c-IAP-1
- c-IAP-2
- Apoptosis-inducing factor
|
|
|
TNF receptor superfamily modulators
|
| LTB (TNFβ) |
- Agonists: Lymphotoxin (α (TNFβ), β (TNFC))
- Decoy receptors: Baminercept
|
| TNF (TNFα) |
| TNFR1 |
- Agonists: Plusonermin
- Sonermin
- Tasonfermin
- TNF (TNFα)
|
| TNFR2 |
- Agonists: Plusonermin
- Sonermin
- Tasonfermin
- TNF (TNFα)
|
| Ungrouped |
- Antibodies: Adalimumab
- Afelimomab
- Certolizumab pegol
- Golimumab
- Infliximab
- Nerelimomab
- Ozoralizumab
- Remtolumab
- Placulumab
- Decoy receptors: Etanercept
- Lenercept
- Onercept
- Pegsunercept
- Enzyme inhibitors: Apratastat
- Other inhibitors: Apremilast
- Bupropion
- Catechins (green tea)
- Cannabinoids (cannabis, Echinacea purpurea)
- Curcumin (turmeric)
- LA-SS-Az
- Lenalidomide
- LSD
- Pentoxifylline
- Pomalidomide
- R-DOI
- TCB-2
- Thalidomide
|
|
| Others |
- TNF superfamily protein ligands: 4-1BBL (CD137L, TNFSF9)
- APRIL (CD256, TNFSF13)
- BAFF (CD257, TNFSF13B)
- CAML
- CD70 (CD27L, TNFSF7)
- CD153 (CD30L, TNFSF8)
- CD154 (CD40L, TNFSF5)
- Ectodysplasin (A, A2)
- FasL (CD95L, TNFSF6)
- GITRL (TNFSF18)
- LIGHT (HEVML, CD258, TNFSF14)
- OX40L (CD252, TNFSF4)
- RANKL (TRANCE, OPGL, ODF, CD254, TNFSF11)
- Siva (CD27BP)
- TRAIL (CD253, TNFSF10)
- TWEAK (TNFSF12)
- VEGI (TL1A, TNFSF15)
- Recombinant proteins: Ardenermin
- Dulanermin
- Antibodies: Belimumab
- Brentuximab vedotin
- Conatumumab
- Dacetuzumab
- Denosumab
- Drozitumab
- Enavatuzumab
- Iratumumab
- Lexatumumab
- Lucatumumab
- Mapatumumab
- Oxelumab
- Ruplizumab
- Tabalumab
- Tavolixizumab
- Teneliximab
- Tigatuzumab
- Toralizumab
- Urelumab
- Utomilumab
- Varlilumab
- Vorsetuzumab
- Vorsetuzumab mafodotin
- Decoy receptors: Briobacept
- Other inhibitors: Blisibimod
|
- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Cytokine receptor modulators
|
UpToDate Contents
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English Journal
- Caspase-3 serves as an intracellular immune receptor specific for lipopolysaccharide in oyster Crassostrea gigas.
- Xu J1, Jiang S2, Li Y1, Li M1, Cheng Q3, Zhao D3, Yang B1, Jia Z1, Wang L2, Song L4.
- Developmental and comparative immunology.Dev Comp Immunol.2016 Aug;61:1-12. doi: 10.1016/j.dci.2016.03.015. Epub 2016 Mar 16.
- Apoptosis is a form of programmed cell death process controlled by a family of cysteine proteases called caspases, which plays a crucial role in the immune system homeostasis. The apoptosis and the detailed regulation mechanism have been well studied in vertebrate, but the information in lower anima
- PMID 26993662
- Endoplasmic reticulum stress in brain ischemia.
- Su Y1, Li F1.
- The International journal of neuroscience.Int J Neurosci.2016 Aug;126(8):681-91. doi: 10.3109/00207454.2015.1059836. Epub 2015 Aug 18.
- Endoplasmic reticulum (ER) stress is an intricate mechanism that mediates numerous responses during brain ischemia, thus being essential to determine the fate of neurons. In recent years, studies of the mechanisms of brain ischemic injury have centered on ER stress, glutamate excitotoxicity, dysfunc
- PMID 26289799
- Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation.
- Huang A1, Ju HQ2, Liu K2, Zhan G2, Liu D2, Wen S2, Garcia-Manero G3, Huang P4, Hu Y5.
- Cancer letters.Cancer Lett.2016 Jul 28;377(2):149-57. doi: 10.1016/j.canlet.2016.04.040. Epub 2016 Apr 28.
- Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two
- PMID 27132990
Japanese Journal
- Boiogito Increases the Metabolism of Fatty Acids in Proximal Tubular Cells through Peroxisome Proliferators-Activated Receptor (PPAR) α Agonistic Activity
- Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis.
- Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change
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- death receptor、DR
- 関
- デスレセプター、デスドメイン受容体
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- 関
- death receptor
[★]
- 英
- death receptor、DR
- 関
- 細胞死受容体
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