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English Journal

Influence of antimuscarinic therapy on cognitive functions and quality of life in geriatric patients treated for overactive bladder.

Esin E1, Ergen A, Cankurtaran M, Yavuz BB, Halil M, Ulger Z, Yeşil Y, Kuyumcu ME, Ozcan M, Cankurtaran E, Ariogul S.
Aging & mental health.Aging Ment Health.2015 Mar;19(3):217-23. doi: 10.1080/13607863.2014.922528.
OBJECTIVES: Incidences of overactive bladder (OAB) and cognitive dysfunction increase with aging. Treatment of OAB with antimuscarinic agents may result in cognitive decline, especially in patients with Alzheimer's disease (AD). The aim of this study is to evaluate the effect of antimuscarinic treat
PMID 25555041

Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening.

Wang Y1, Law WK, Hu JS, Lin HQ, Ip TM, Wan DC.
Journal of chemical information and modeling.J Chem Inf Model.2014 Nov 24;54(11):3046-50. doi: 10.1021/ci500503b. Epub 2014 Nov 4.
We first identified fluorescein, ketazolam, antrafenine, darifenacin, fosaprepitant, paliperidone, risperidone, pimozide, trovafloxacin, and levofloxacin as inhibitors of fatty acid binding protein 4 using molecular docking screening from FDA-approved drugs. Subsequently, the biochemical characteriz
PMID 25360897

Discontinuation of treatment using anticholinergic medications in patients with urinary incontinence.

Kalder M1, Pantazis K, Dinas K, Albert US, Heilmaier C, Kostev K.
Obstetrics and gynecology.Obstet Gynecol.2014 Oct;124(4):794-800. doi: 10.1097/AOG.0000000000000468.
OBJECTIVE: To evaluate the discontinuation rates of anticholinergics prescribed in patients with urinary incontinence (UI).METHODS: Data from a Disease Analyzer database including 988 general, 95 urologist, and 203 gynecologic practices were examined. Twenty six thousand eight hundred thirty-four pa
PMID 25198276