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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/30 06:14:46」(JST)

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  • Development and in vitro characterisation of an oral self-emulsifying delivery system for daptomycin.
  • Zupančič O1, Partenhauser A1, Lam HT1, Rohrer J1, Bernkop-Schnürch A2.
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2016 Jan 1;81:129-36. doi: 10.1016/j.ejps.2015.10.005. Epub 2015 Oct 17.
  • It was the aim of this study to develop an oral self-emulsifying drug delivery system (SEDDS) for the peptide drug daptomycin exhibiting an anionic net charge. Drug lipophilicity was increased by hydrophobic ion pairing with cationic surfactant dodecylamine hydrochloride in molar ratio of surfactant
  • PMID 26485536
  • Nationwide surveillance of resistance rates of Staphylococcus aureus clinical isolates from Greek hospitals, 2012-2013.
  • Souli M1, Karaiskos I2, Galani L2, Maraki S3, Perivolioti E4, Argyropoulou A4, Charissiadou A5, Zachariadou L5, Tsiplakou S6, Papaioannou V6, Tsorlini H7, Katsifa H7, Baka V8, Pantazi P8, Paschali A9, Kyratsa A9, Trikka-Graphakos E10, Giannopoulou P10, Vogiatzakis E11, Moraitou H11, Papadogeorgaki H12, Avgerinou H12, Panagea T13, Pantazatou A14, Petinaki E15, Stamatopoulou G16, Toutouza M17, Karatzoglou I18, Kontopoulou K19, Orfanidou M20, Karantani I21, Fytas P22, Tzanetou K23, Platsouka E24, Kazila P25, Chli A26, Statiri N27, Giamarellou H2.
  • Infectious diseases (London, England).Infect Dis (Lond).2015 Dec 4:1-6. [Epub ahead of print]
  • PURPOSE: To evaluate the in vitro efficacy of several anti-staphylococcal agents against a nationwide collection of contemporary Staphylococcus aureus clinical isolates from several healthcare centres in Greece.METHODS: Thirty hospitals throughout Greece (18 in Attica) provided all clinical isolates
  • PMID 26635179
  • Safety and efficacy of commonly used antimicrobial agents in the treatment of enterococcal infections: A review.
  • Suleyman G1,2, Zervos MJ1,2.
  • Expert opinion on drug safety.Expert Opin Drug Saf.2015 Dec 2. [Epub ahead of print]
  • INTRODUCTION: Enterococci have become the second leading cause of nosocomial infections in the U.S, which are associated with higher morbidity, mortality, length of stay, and cost due to escalating resistance to several antimicrobial agents. With limited treatment options, the adverse events associa
  • PMID 26629598








daptomycin, DAP, DAPT
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Streptomyces roseosporusの発酵産物から得られた抗菌薬/抗生物質。

  • 13個のアミノ酸残基からなり、そのうち10アミノ酸残基が環を形成し、N末端のトリプトファンにデカノイル基が結合している。
  • メチシリン耐性黄色ブドウ球菌(MRSA)を含む、Staphylococcus属、Enterococcus属、Streptococcus属といった、臨床上重要なグラム陽性菌に対し殺菌作用を示す。