cytotoxic conjugates

出典: meddic

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  • Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells.
  • Zhang L1, Liu L2, Zheng C2, Wang Y2, Nie X2, Shi D2, Chen Y2, Wei G3, Wang J4.
  • European journal of medicinal chemistry.Eur J Med Chem.2017 May 5;131:81-91. doi: 10.1016/j.ejmech.2017.03.011. Epub 2017 Mar 8.
  • PMID 28301815
  • Mitoxantrone- and Folate-TPGS2k Conjugate Hybrid Micellar Aggregates To Circumvent Toxicity and Enhance Efficiency for Breast Cancer Therapy.
  • Guissi NE1,2, Li H1, Xu Y1, Semcheddine F3, Chen M1, Su Z1, Ping Q1.
  • Molecular pharmaceutics.Mol Pharm.2017 Apr 3;14(4):1082-1094. doi: 10.1021/acs.molpharmaceut.6b01009. Epub 2017 Feb 24.
  • PMID 28191959
  • Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix.
  • Gébleux R1, Stringhini M1, Casanova R2, Soltermann A2, Neri D1.
  • International journal of cancer.Int J Cancer.2017 Apr 1;140(7):1670-1679. doi: 10.1002/ijc.30569. Epub 2016 Dec 30.
  • PMID 27943268


  • 薬剤アレルギーの発症機構とその診断検査への取り組み
  • 抗体薬物複合体療法
  • Mass Spectrometric Approaches to the Identification of Potential Ingredients in Cigarette Smoke Causing Cytotoxicity


Today, two main categories of highly potent cytotoxic anticancer agents are used in antibody-drug conjugates: microtubule disrupting agents and DNA mo… ... Today, two main categories of highly potent cytotoxic anticancer agents ...
1. ACS Nano. 2009 Sep 22;3(9):2505-14. doi: 10.1021/nn900318y. Fullerenol-cytotoxic conjugates for cancer chemotherapy. Chaudhuri P, Paraskar A, Soni S, Mashelkar RA, Sengupta S. Laboratory of Nanomedicine, HST Center for ...


conjugates2Patent DrawingTo download the Bioconjugation brochure Cytotoxic Conjugates Comprising A Antibody drug conjugateAntibody-Drug Conjugates




  • n.
  • vt.
  • (言語)(動詞)を活用/変化させる。
  • (化学)~を共役させる。
  • vi.
  • (生物)接合する。(言語)動詞が活用/変化する。
  • 抱合する、接合する、結合する、共役する
  • adj.

WordNet   license wordnet

「undergo conjugation」

WordNet   license wordnet

「unite chemically so that the product is easily broken down into the original compounds」

PrepTutorEJDIC   license prepejdic

「〈動詞〉'を'活用(変化)させる / 〈動詞が〉活用(変化)する / 〈単細胞生物が〉接合する / (特に対になって)結合した,接合の」

WordNet   license wordnet

「formed by the union of two compounds; "a conjugated protein"」

WordNet   license wordnet

「of an organic compound; containing two or more double bonds each separated from the other by a single bond」

WordNet   license wordnet

「joined together especially in a pair or pairs」
conjugated, coupled

WordNet   license wordnet

「(of a pinnate leaflet) having only one pair of leaflets」

WordNet   license wordnet

「add inflections showing person, number, gender, tense, aspect, etc.; "conjugate the verb"」



  • adj.
  • 細胞傷害性の、細胞毒性の、細胞障害性の、細胞傷害の
cell injurycellular injurycytotoxicity

WordNet   license wordnet

「of or relating to substances that are toxic to cells」