cytotoxic conjugates

出典: meddic

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  • Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells.
  • Zhang L1, Liu L2, Zheng C2, Wang Y2, Nie X2, Shi D2, Chen Y2, Wei G3, Wang J4.
  • European journal of medicinal chemistry.Eur J Med Chem.2017 May 5;131:81-91. doi: 10.1016/j.ejmech.2017.03.011. Epub 2017 Mar 8.
  • PMID 28301815
  • Mitoxantrone- and Folate-TPGS2k Conjugate Hybrid Micellar Aggregates To Circumvent Toxicity and Enhance Efficiency for Breast Cancer Therapy.
  • Guissi NE1,2, Li H1, Xu Y1, Semcheddine F3, Chen M1, Su Z1, Ping Q1.
  • Molecular pharmaceutics.Mol Pharm.2017 Apr 3;14(4):1082-1094. doi: 10.1021/acs.molpharmaceut.6b01009. Epub 2017 Feb 24.
  • PMID 28191959
  • Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix.
  • Gébleux R1, Stringhini M1, Casanova R2, Soltermann A2, Neri D1.
  • International journal of cancer.Int J Cancer.2017 Apr 1;140(7):1670-1679. doi: 10.1002/ijc.30569. Epub 2016 Dec 30.
  • PMID 27943268



Today, two main categories of highly potent cytotoxic anticancer agents are used in antibody-drug conjugates: microtubule disrupting agents and DNA mo… ... Today, two main categories of highly potent cytotoxic anticancer agents ...
1. ACS Nano. 2009 Sep 22;3(9):2505-14. doi: 10.1021/nn900318y. Fullerenol-cytotoxic conjugates for cancer chemotherapy. Chaudhuri P, Paraskar A, Soni S, Mashelkar RA, Sengupta S. Laboratory of Nanomedicine, HST Center for ...






  • n.
  • vt.
  • (言語)(動詞)を活用/変化させる。
  • (化学)~を共役させる。
  • vi.
  • (生物)接合する。(言語)動詞が活用/変化する。
  • 抱合する、接合する、結合する、共役する
  • adj.

WordNet   license wordnet

「undergo conjugation」

WordNet   license wordnet

「unite chemically so that the product is easily broken down into the original compounds」

PrepTutorEJDIC   license prepejdic

「〈動詞〉'を'活用(変化)させる / 〈動詞が〉活用(変化)する / 〈単細胞生物が〉接合する / (特に対になって)結合した,接合の」

WordNet   license wordnet

「formed by the union of two compounds; "a conjugated protein"」

WordNet   license wordnet

「of an organic compound; containing two or more double bonds each separated from the other by a single bond」

WordNet   license wordnet

「joined together especially in a pair or pairs」
conjugated, coupled

WordNet   license wordnet

「(of a pinnate leaflet) having only one pair of leaflets」

WordNet   license wordnet

「add inflections showing person, number, gender, tense, aspect, etc.; "conjugate the verb"」



  • adj.
  • 細胞傷害性の、細胞毒性の、細胞障害性の、細胞傷害の
cell injurycellular injurycytotoxicity

WordNet   license wordnet

「of or relating to substances that are toxic to cells」