cytotoxic conjugates

WordNet

1. undergo conjugation
2. unite chemically so that the product is easily broken down into the original compounds
3. formed by the union of two compounds; "a conjugated protein" (同)conjugated
4. of an organic compound; containing two or more double bonds each separated from the other by a single bond (同)conjugated
5. joined together especially in a pair or pairs (同)conjugated, coupled
6. (of a pinnate leaflet) having only one pair of leaflets
7. add inflections showing person, number, gender, tense, aspect, etc.; "conjugate the verb"
8. of or relating to substances that are toxic to cells

PrepTutorEJDIC

1. 〈動詞〉'を'活用(変化)させる / 〈動詞が〉活用(変化)する / 〈単細胞生物が〉接合する / (特に対になって)結合した,接合の

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• 1. 去勢抵抗性前立腺癌に対する免疫療法 immunotherapy for castration resistant prostate cancer
• 2. 進行皮膚黒色腫に対するマネージメントの概要 overview of the management of advanced cutaneous melanoma
• 3. 転移性黒色腫（メラノーマ）の細胞傷害性化学療法 cytotoxic chemotherapy for metastatic melanoma
• 4. 成人男性における細胞傷害性薬物が性腺機能に及ぼす影響 effects of cytotoxic agents on gonadal function in adult men
• 5. 抗腫瘍療法関連肺毒性：細胞傷害性薬物 pulmonary toxicity associated with antineoplastic therapy cytotoxic agents

English Journal

• Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells.

• Zhang L1, Liu L2, Zheng C2, Wang Y2, Nie X2, Shi D2, Chen Y2, Wei G3, Wang J4.
• European journal of medicinal chemistry.Eur J Med Chem.2017 May 5;131:81-91. doi: 10.1016/j.ejmech.2017.03.011. Epub 2017 Mar 8.
• PMID 28301815

• Mitoxantrone- and Folate-TPGS2k Conjugate Hybrid Micellar Aggregates To Circumvent Toxicity and Enhance Efficiency for Breast Cancer Therapy.

• Guissi NE1,2, Li H1, Xu Y1, Semcheddine F3, Chen M1, Su Z1, Ping Q1.
• Molecular pharmaceutics.Mol Pharm.2017 Apr 3;14(4):1082-1094. doi: 10.1021/acs.molpharmaceut.6b01009. Epub 2017 Feb 24.
• PMID 28191959

• Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix.

• Gébleux R1, Stringhini M1, Casanova R2, Soltermann A2, Neri D1.
• International journal of cancer.Int J Cancer.2017 Apr 1;140(7):1670-1679. doi: 10.1002/ijc.30569. Epub 2016 Dec 30.
• PMID 27943268

Japanese Journal

• 薬剤アレルギーの発症機構とその診断検査への取り組み

• YAKUGAKU ZASSHI 138(2), 151-167, 2018
• NAID 130006328030

• 抗体薬物複合体療法

• 日大医学雑誌 76(1), 15-18, 2017
• NAID 130005464737

• Mass Spectrometric Approaches to the Identification of Potential Ingredients in Cigarette Smoke Causing Cytotoxicity

• Biological and Pharmaceutical Bulletin 39(6), 903-908, 2016
• NAID 130005155134

Related Links

• Cytotoxic Agents - ADC Review / Journal of Antibody-drug ...

Today, two main categories of highly potent cytotoxic anticancer agents are used in antibody-drug conjugates: microtubule disrupting agents and DNA mo… ... Today, two main categories of highly potent cytotoxic anticancer agents ...

• Fullerenol-cytotoxic conjugates for cancer chemotherapy.

1. ACS Nano. 2009 Sep 22;3(9):2505-14. doi: 10.1021/nn900318y. Fullerenol-cytotoxic conjugates for cancer chemotherapy. Chaudhuri P, Paraskar A, Soni S, Mashelkar RA, Sengupta S. Laboratory of Nanomedicine, HST Center for ...

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★リンクテーブル★

関連記事	「conjugate」「cytotoxic」

「conjugate」

　　[★]

• n.

• 抱合体、接合体、複合物

• vt.

• (言語)(動詞)を活用/変化させる。
• (化学)～を共役させる。

• vi.

• (生物)接合する。(言語)動詞が活用/変化する。
• 抱合する、接合する、結合する、共役する

• adj.

関

associate、bind、binding、bond、bonding、combine、complex、conjoin、conjugated、conjugation、conjunction、connect、connection、couple、coupling、dock、engage、engagement、join、juncture、ligate、linkage、mating、symphysial、union、zygote、zygotic

　 　 　 　 　 　 　 　

「cytotoxic」

　　[★]

• adj.

• 細胞傷害性の、細胞毒性の、細胞障害性の、細胞傷害の

関

cell injury、cellular injury、cytotoxicity