シトシンデアミナーゼ、シトシン脱アミノ化酵素
WordNet
- a base found in DNA and RNA and derived from pyrimidine; pairs with guanine (同)C
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/20 00:55:15」(JST)
[Wiki en表示]
| cytosine deaminase |
| Identifiers |
| EC number |
3.5.4.1 |
| CAS number |
9025-05-2 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / QuickGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a cytosine deaminase (EC 3.5.4.1) is an enzyme that catalyzes the chemical reaction
- cytosine + H2O uracil + NH3
Thus, the two substrates of this enzyme are cytosine and H2O, whereas its two products are uracil and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytosine aminohydrolase. This enzyme is also called isocytosine deaminase. This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1K6W, 1K70, 1OX7, 1P6O, 1R9X, 1R9Y, 1RA0, 1RA5, 1RAK, 1RB7, 1UAQ, 1YSB, and 1YSD.
References
- COHEN SS, BARNER HD (1957). "The conversion of 5-methyldeoxycytidine to thymidine in vitro and in vivo". J. Biol. Chem. 226 (2): 631–42. PMID 13438848.
- Kream J; Chargaff E (1952). "On the cytosine deaminase of yeast". J. Am. Chem. Soc. 74 (20): 5157–5160. doi:10.1021/ja01140a050.
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Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
|
3.5.1: Linear amides /
Amidohydrolases |
- Asparaginase
- Glutaminase
- Urease
- Biotinidase
- Aspartoacylase
- Ceramidase
- Aspartylglucosaminidase
- Fatty acid amide hydrolase
- Histone deacetylase
|
3.5.2: Cyclic amides/
Amidohydrolases |
- Barbiturase
- Beta-lactamase
|
3.5.3: Linear amidines/
Ureohydrolases |
- Arginase
- Agmatinase
- Protein-arginine deiminase
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3.5.4: Cyclic amidines/
Aminohydrolases |
- Guanine deaminase
- Adenosine deaminase
- AMP deaminase
- Inosine monophosphate synthase
- DCMP deaminase
- GTP cyclohydrolase I
- Cytidine deaminase
- AICDA
- Activation-induced cytidine deaminase
|
3.5.5: Nitriles/
Aminohydrolases |
|
| 3.5.99: Other |
- Riboflavinase
- Thiaminase II
|
|
Enzymes
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
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English Journal
- Product release mechanism and the complete enzyme catalysis cycle in yeast cytosine deaminase (yCD): A computational study.
- Zhao Y1, She N2, Zhang X3, Wang C4, Mo Y5.
- Biochimica et biophysica acta.Biochim Biophys Acta.2017 Aug;1865(8):1020-1029. doi: 10.1016/j.bbapap.2017.05.001. Epub 2017 May 3.
- PMID 28478051
- The new frontier of epigenetic heterogeneity in B-cell neoplasms.
- Dominguez PM1, Teater M, Shaknovich R.
- Current opinion in hematology.Curr Opin Hematol.2017 Jul;24(4):402-408. doi: 10.1097/MOH.0000000000000348.
- PMID 28375986
- Cytosine deaminase APOBEC3A sensitizes leukemia cells to inhibition of the DNA replication checkpoint.
- Green AM1, Budagyan K2, Hayer KE3, Reed MA2, Savani MR4, Wertheim GB5, Weitzman MD6.
- Cancer research.Cancer Res.2017 Jun 27. pii: canres.3394.2016. doi: 10.1158/0008-5472.CAN-16-3394. [Epub ahead of print]
- PMID 28655787
Japanese Journal
- Characterization of the deamination coupled with sliding along DNA of anti-HIV factor APOBEC3G on the basis of the pH-dependence of deamination revealed by real-time NMR monitoring
- Absence of a gene encoding cytosine deaminase in the genome of the agaricomycete Coprinopsis cinerea enables simple marker recycling through 5-fluorocytosine counterselection.
- Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination.
Related Links
- Cytosine deaminase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Cytosine deaminase Description of Cytosine deaminase Cytosine deaminase: An ...
- Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a ...
★リンクテーブル★
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- 英
- cytosine deaminase
- 関
- シトシン脱アミノ化酵素
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- 英
- cytosine deaminase
- 関
- シトシンデアミナーゼ
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デアミナーゼ、脱アミノ酵素
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シトシン
- 同
- C