cytochrome P450 system

出典: meddic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/13 10:58:23」(JST)

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  • Environmental monitoring of urban streams using a primary fish gill cell culture system (FIGCS).
  • Schnell S1, Bawa-Allah K2, Otitoloju A2, Hogstrand C1, Miller TH3, Barron LP3, Bury NR4.
  • Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2015 Oct;120:279-85. doi: 10.1016/j.ecoenv.2015.06.012. Epub 2015 Jun 17.
  • The primary fish gill cell culture system (FIGCS) is an in vitro technique which has the potential to replace animals in whole effluent toxicity tests. In the current study FIGCS were transported into the field and exposed to filtered (0.2μm) river water for 24h from 4 sites, on 2 different samplin
  • PMID 26093110
  • Improved assays for xenosensor activation based on reverse transfection.
  • Küblbeck J1, Anttila T2, Pulkkinen JT2, Honkakoski P2.
  • Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2015 Oct;29(7):1759-65. doi: 10.1016/j.tiv.2015.07.011. Epub 2015 Jul 14.
  • Discovery of receptor-dependent mechanisms for regulation of drug metabolism has provided a new way to evaluate the propensity of drug candidates to cause induction of cytochrome P450 enzymes. Therefore, receptor-based reporter assays have become common in early stages of drug development projects a
  • PMID 26187274
  • Reconstitution of the In Vitro Activity of the Cyclosporine-Specific P450 Hydroxylase from Sebekia benihana and Development of a Heterologous Whole-Cell Biotransformation System.
  • Ma L1, Du L1, Chen H1, Sun Y2, Huang S2, Zheng X1, Kim ES3, Li S4.
  • Applied and environmental microbiology.Appl Environ Microbiol.2015 Sep 15;81(18):6268-75. doi: 10.1128/AEM.01353-15. Epub 2015 Jul 6.
  • The cytochrome P450 enzyme CYP-sb21 from Sebekia benihana is capable of catalyzing the site-specific hydroxylation of the immunosuppressant cyclosporine (CsA), leading to the single product γ-hydroxy-N-methyl-l-Leu4-CsA (CsA-4-OH). Unlike authentic CsA, this hydroxylated CsA shows significantly red
  • PMID 26150455


  • Enhanced oxidative activities of cytochrome P450Rhf from Rhodococcus sp. expressed using the hyper-inducible expression system
  • Ueno Motoi,Yamashita Midori,Takase Shigehiro [他]
  • Journal of bioscience and bioengineering 117(1), 19-24, 2014-01
  • NAID 40019948868
  • Enhanced oxidative activities of cytochrome P450Rhf from Rhodococcus sp. expressed using the hyper-inducible expression system(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
  • Ueno Motoi,Yamashita Midori,Takase Shigehiro,Hino Motohiro,Kobayashi Michihiko,Fujie Akihiko
  • Journal of bioscience and bioengineering 117(1), 19-24, 2014-01
  • … Bacterial cytochrome P450 enzymes catalyze the oxidative biotransformation of various types of compounds. … Although the functional expression of Actinomycetes P450 in a closely related heterologous host can serve as a useful biocatalyst in whole-cell biotransformation assays, the co-expression of an electron transfer partner is required. … To overcome this limitation, P450Rhf from Rhodococcus sp. …
  • NAID 110009766598
  • Evaluation of Three-Dimensional Cultured HepG2 Cells in a Nano Culture Plate System: an In Vitro Human Model of Acetaminophen Hepatotoxicity
  • Aritomi Kohei,Ishitsuka Yoichi,Tomishima Yoshiro,Shimizu Daisuke,Abe Nazuki,Shuto Tsuyoshi,Irikura Mitsuru,Kai Hirofumi,Irie Tetsumi
  • Journal of Pharmacological Sciences, 2014
  • … This study examined the characteristics and usefulness of HepG2 cells grown in a nano culture plate (NCP) system, a three-dimensional culture method, as an in vitro human model for APAP-induced hepatotoxicity. … The NCP-cultured HepG2 cells showed higher expression of mRNA and protein levels of cytochrome P450 2E1, which metabolizes APAP to a toxic metabolite, APAP-cysteine adduct formation, and higher sensitivity against APAP-induced cell injury compared with conventionally cultured cells. …
  • NAID 130003391476



Cytochrome P450Divinely Toxic - Mycotoxins, Toxic Mold, Toxins, Candida and YouFigure 1: Generalized picture of the microsomal P450 systemBiodégradation Des PolluantsAcide Cleanup Recommendation ReportSimultaneous pharmacodynamic analysis of the lag and bactericidal




  • n.

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「(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"」

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「instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"」

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「a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going"」

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「a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender"」
system of rules

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「a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"」

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「a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"」

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「the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"」

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「〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身」


  [★] シトクロム

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「(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)」