WordNet

the 16th letter of the Roman alphabet (同)p
(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)
a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

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Structural and energetic analysis to provide insight residues of CYP2C9, 2C11 and 2E1 involved in valproic acid dehydrogenation selectivity.

Bello M1, Mendieta-Wejebe JE2, Correa-Basurto J3.
Biochemical pharmacology.Biochem Pharmacol.2014 May 2. pii: S0006-2952(14)00258-5. doi: 10.1016/j.bcp.2014.04.016. [Epub ahead of print]
Docking and molecular dynamics (MD) simulation have been two computational techniques used to gain insight about the substrate orientation within protein active sites, allowing to identify potential residues involved in the binding and catalytic mechanisms. In this study, both methods were combined
PMID 24794636

Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.

Howell BA1, Siler SQ2, Watkins PB2.
Toxicology letters.Toxicol Lett.2014 Apr 21;226(2):163-72. doi: 10.1016/j.toxlet.2014.02.007. Epub 2014 Feb 18.
Acetaminophen (APAP) has been used as a probe drug to investigate drug-induced liver injury (DILI). In mice, 3'-hydroxyacetanilide (AMAP), a less-toxic isomer of APAP, has also been studied as a negative control. Various mechanisms for the divergence in toxicological response between the two isomers
PMID 24560604

Hartman JH1, Miller GP1, Boysen G2.
Toxicology.Toxicology.2014 Apr 6;318:51-8. doi: 10.1016/j.tox.2014.02.003. Epub 2014 Feb 18.
CYP2E1 has been implicated in the bioactivation of many small molecules into reactive metabolites which form adducts with proteins and DNA, and thus a better understanding of the molecular determinants of its selectivity are critical for accurate toxicological predictions. In this study, we determin
PMID 24561005

Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities

Nishimura Yuki,Kurata Norimitsu,Sakurai Eriko [他],YASUHARA Hajime
Journal of pharmacological sciences 96(3), 293-300, 2004-11-20
… The potential for drug-drug interactions mediated by the inhibition of cytochrome P-450 (CYP) were concerned during antituberculosis therapy. … In contrast, in addition to the reported inhibitory effect of isoniazid on CYP1A2, CYP2A6, CYP2C19, and CYP3A activities, our results newly showed its effect on CYP2C9 and CYP2E1 activities. …
NAID 10014167341

Lack of an Inducible Effect of Dietary Soy Isoflavones on the mRNA Abundance of Hepatic Cytochrome P-450 Isozymes in Rats

Kishida Taro,Nagamoto Manabu,Ohtsu Yohhei [他],WATAKABE Miho,OHSHIMA Daisuke,NASHIKI Kunitaka,MIZUSHIGE Takafumi,IZUMI Tohru,OBATA Akio,EBIHARA Kiyoshi
Bioscience, biotechnology, and biochemistry 68(3), 508-515, 2004-03-23
… Modulation of the activity and content of cytochrome P-450 (CYP) in hepatic microsomes may be important to human health since these enzymes activate and inactivate a wide range of xenobiotics and food components. …
NAID 10013142524

KISHIMOTO Ritsuko,OGISHI Yasuka,UEDA Miwa,MATSUSAKI Mari,AMAKO Katumi,GODA Kiyoshi,PARK Sang-Shin
Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ　 48(3), 216-224, 2002
… Moreover, the density of the band of CYP2E1 in the microsome in female mice was stronger than in male mice, and in the microsomal fraction of the liver, the total content of cytochrome P-450 (CYP) and ethoxyresorufin O-dealkylase (EROD) activity in male mice showed significantly higher values than in female mice. …
NAID 130001377117