WordNet

the 16th letter of the Roman alphabet (同)p
(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)
a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

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parking
phosphorusの化学記号
palladiumの化学記号

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1. 薬理ゲノム学の概要 overview of pharmacogenomics
2. ミトコンドリアミオパシー：臨床的特徴および診断 mitochondrial myopathies clinical features and diagnosis
3. クロピドグレル耐性とクロピドグレル治療不奏効 clopidogrel resistance and clopidogrel treatment failure
4. 成人における抗癌剤の投与 dosing of anticancer agents in adults
5. 2型糖尿病の治療のためのジペプチジルペプチダーゼ4（DPP-4）阻害剤 dipeptidyl peptidase 4 dpp 4 inhibitors for the treatment of type 2 diabetes mellitus

English Journal

In Vivo Deletion of CAR Resulted in High Bone Mass Phenotypes in Male Mice.

Cho HY, Jung JY, Park H, Yang JY, Jung S, An JH, Cho SW, Kim SW, Kim SY, Kim JE, Park YJ, Shin CS.Author information Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.AbstractConstitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. This study investigated the role of CAR in the regulation of bone mass in vivo using CAR(-/-) mice. Endogenous mRNA expression of CAR was observed in both primary osteoblasts and osteoclast precursors. CAR(-/-) mice have exhibited significant increase in whole body bone mineral density (BMD) by 9.5% (P < 0.01) and 5.5% (P < 0.05) at 10 and 15 weeks of age, respectively, compared with WT mice in males. Microcomputed tomography analysis of proximal tibia demonstrated a significant increase in trabecular bone volume (62.7%), trabecular number (54.1%) in male CAR(-/-) mice compared with WT mice. However, primary culture of calvarial cells exhibited no significant changes in osteogenic differentiation potential between CAR(-/-) and WT. In addition, the number of tartrate-resistant acid-phosphatase positive osteoclasts in the femur and serum level of CTx was not different between CAR(-/-) and WT mice. The higher BMD and microstructural parameters were not observed in female mice. Interestingly, serum level of testosterone in male CAR(-/-) mice was 2.5-fold higher compared with WT mice and the mRNA expressions of Cyp2b9 and 2b10 in the liver, which regulate testosterone metabolism, were significantly down-regulated in male CAR(-/-) mice. Furthermore, the difference in BMD between CAR(-/-) and WT mice disappeared at 8 weeks after performing orchiectomy. CAR(-/-) mice also exhibited significant increase in serum 1,25(OH)2 D3 levels but Cyp 27B1 which converts 25(OH)D3 to 1,25(OH)2 D3 was significantly down-regulated compared to WT mice. These results suggest that in vivo deletion of CAR resulted in higher bone mass, which appears to be a result from reduced metabolism of testosterone due to down-regulation of Cyp2b. J. Cell. Physiol. 229: 561-571, 2014. © 2013 Wiley Periodicals, Inc.
Journal of cellular physiology.J Cell Physiol.2014 May;229(5):561-71. doi: 10.1002/jcp.24478.
Constitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. Th
PMID 24114688

Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia.

Ivanova SA1, Geers LM2, Al Hadithy AF3, Pechlivanoglou P4, Semke AV5, Vyalova NM5, Rudikov EV5, Fedorenko OY1, Wilffert B2, Bokhan NA5, Brouwers JR2, Loonen AJ6.Author information 1Mental Health Research Institute, Tomsk, Russia; National Research Tomsk Polytechnic University, Tomsk, Russia.2Department of Pharmacy, University of Groningen, Groningen, The Netherlands.3Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Parnassia Group, Pharmacy Haaglanden, The Hague, The Netherlands.4Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.5Mental Health Research Institute, Tomsk, Russia.6Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Mental Health Institute Westelijk Noord-Brabant, Halsteren, The Netherlands. Electronic address: a.j.m.loonen@rug.nl.AbstractBACKGROUND: Tardive dyskinesia (TD) is a potentially irreversible consequence of long term treatment with antipsychotic drugs which is according to a well-known theory believed to be related to oxidative stress induced neurotoxicity. Dehydroepiandrosterone (DHEA) is an endogenous antioxidant with neuroprotective activity. The biosynthesis of DHEA depends upon the activity of cytochrome P450c17α (CYP17). The gene that encodes for CYP17 has a (T34C) single nucleotide polymorphism which enhances CYP17 transcription and expression.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Apr 3;50:172-7. doi: 10.1016/j.pnpbp.2013.12.015. Epub 2014 Jan 3.
BACKGROUND: Tardive dyskinesia (TD) is a potentially irreversible consequence of long term treatment with antipsychotic drugs which is according to a well-known theory believed to be related to oxidative stress induced neurotoxicity. Dehydroepiandrosterone (DHEA) is an endogenous antioxidant with ne
PMID 24389397

Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1.

Zhang Z, Lu H, Huan F, Meghan C, Yang X, Wang Y, Wang X, Wang X, Wang SL.Author information Key Lab of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; State Key Lab of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, People's Republic of China.AbstractCytochrome P450 2A13 (CYP2A13), mainly expressed in human respiratory tract, is highly efficient in the metabolic activation of aflatoxin (AF) B1 (AFB1) and is assumed to play a role in human lung tumorigenesis in airborne AFB1 exposure. To validate the assumption, we exposed human bronchial epithelial (BEAS-2B) cells stably expressing CYP2A13 (B-2A13), CYP1A2 (B-1A2) and CYP2A6 (B-2A6) to 0.1-10 nM AFB1 for 30-50 passages. B-2A13 cells showed increased sensitivity to 0.1 nM AFB1-induced neoplastic transformation and the formation of tumors in nude mice were observed at passage 30 (P30) while it occurred at P50 B-1A2 cells. B-2A6, similar to vector control, showed no neoplastic transformation in this condition. Additionally, AFB1-DNA adducts and 8-OHdG significantly increased in transformed P40 B-2A13, in parallel with the upregulation of p-ATR, p-BRCA1, Mre11, Rad50 and Rad51. However, the apoptosis of P40 cells was near normal, while the expression of Bax, C-Caspase 3 and C-PARP increased passage-dependently. Inhibition of ATR (ATR siRNA or NU6027) reversely increased the apoptosis of P40 B-2A13 cells in parallel with the upregulation of Bax, C-Caspase 3 and C-PARP, suggesting that ATR plays an important role in maintaining cell survival via antiapoptosis. Additionally, activation of ATR was necessary to neoplastic transformation since blockage of ATR in P40 cells inhibited DNA damage repair response and anchorage-independent growth. Our data demonstrated that CYP2A13 played a critical role in AFB1-induced neoplastic transformation. ATR-mediated the dysfunction of apoptosis and DNA damage repair might be involved. These results help establish a linkage between airborne AFB1 and human respiratory carcinoma.
International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 1;134(7):1539-48. doi: 10.1002/ijc.28489. Epub 2013 Oct 11.
Cytochrome P450 2A13 (CYP2A13), mainly expressed in human respiratory tract, is highly efficient in the metabolic activation of aflatoxin (AF) B1 (AFB1) and is assumed to play a role in human lung tumorigenesis in airborne AFB1 exposure. To validate the assumption, we exposed human bronchial epithel
PMID 24114584

Japanese Journal

豚肉中のミオグロビン,ヘモグロビンならびにシトクロムcの同時定量法の検討

日本養豚学会誌 = The Japanense journal of swine science 53(1), 10-16, 2016-03
NAID 40020752180

ITO電極とチトクロームcの直接電子移動反応 (有機エレクトロニクス)

電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 115(389), 1-5, 2016-01-08
NAID 40020737826

MERRF様の筋病理を呈したMELASの1例

臨床神経学 advpub(0), 2016
NAID 130005132732

Related Pictures

Cytochrome P450 High Resolution Stock Photography and Images - Alamy Cytochrome P450 Complex Photograph by Laguna Design/science Photo Cytochrom P450 Stockfotografie - Alamy Typical structure of a cytochrome P450, exemplified by OxyB tei Human cytochrome P450 molecule - Stock Image - C035/5596 - Science Scott Lab | Human cytochrome P450 2E1 Cytochrome P450 Molecule Photograph by Dr Mark J. Winter

★リンクテーブル★

リンク元	「シトクロムP450」
拡張検索	「cytochrome P-450 CYP2D6」「cytochrome P-450 CYP3A」「cytochrome P-450 linked mixed function oxidase」「cytochrome P-450 monooxygenase system」
関連記事	「P」「p」「Pd」