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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/11 03:34:09」(JST)

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Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.^[1]^[2]^[3]

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.^[3]

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

File:FluoropyrimidineActivity_WP1601.png

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

^ Kuhn K, Bertling WM, Emmrich F (Feb 1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochem Biophys Res Commun 190 (1): 1–7. doi:10.1006/bbrc.1993.1001. PMID 8422236.
^ Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E (Feb 1999). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochim Biophys Acta 1443 (3): 323–33. doi:10.1016/s0167-4781(98)00235-8. PMID 9878810.
^ ^a ^b "Entrez Gene: CDA cytidine deaminase".

UpToDate Contents

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5. 成人における分類不能型免疫不全の臨床症状、疫学、および診断 clinical manifestations epidemiology and diagnosis of common variable immunodeficiency in adults

English Journal

Detection of APOBEC3 Proteins and Catalytic Activity in Urothelial Carcinoma.

Jaguva Vasudevan AA1,2, Goering W2,3, Häussinger D1, Münk C4.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2018;1655:97-107. doi: 10.1007/978-1-4939-7234-0_8.
PMID 28889380

Spectroscopic and calorimetric assays reveal dependence on dCTP and two metals (Zn2++Mg2+) for enzymatic activity of Schistosoma mansoni deoxycytidylate (dCMP) deaminase.

Scortecci JF1, Serrão VHB2, Cheleski J1, Torini JR1, Romanello L1, DeMarco R1, D'Muniz Pereira H1.
Biochimica et biophysica acta.Biochim Biophys Acta.2017 Nov;1865(11 Pt A):1326-1335. doi: 10.1016/j.bbapap.2017.07.015. Epub 2017 Aug 12.
PMID 28807888

Malaria, Epstein-Barr virus infection and the pathogenesis of Burkitt's lymphoma.

Mawson AR1, Majumdar S2.
International journal of cancer.Int J Cancer.2017 Nov 1;141(9):1849-1855. doi: 10.1002/ijc.30885. Epub 2017 Jul 24.
PMID 28707393

Japanese Journal

Cytidine deaminase polymorphisms and worse treatment response in normal karyotype AML

Journal of human genetics 60(12), 749-754, 2015-12
NAID 40020677300

Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis.

Carcinogenesis 36(8), 904-913, 2015-08
NAID 120005676642

ヒト口腔扁平上皮癌におけるStreptococcus anginosus感染とactivation-induced cytidine deaminase (AID)異所性発現

岩手医科大学歯学雑誌 40(1), 26-37, 2015-04-23
NAID 110009936933

★リンクテーブル★

リンク元	「シチジンデアミナーゼ」「シチジン脱アミノ化酵素」
拡張検索	「activation-induced cytidine deaminase」「deoxycytidine deaminase」
関連記事	「deaminase」

「シチジンデアミナーゼ」

Cytidine deaminase
	PDB rendering based on 1mq0.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1MQ0
Identifiers
Symbols	CDA ; CDD
External IDs	OMIM: 123920 MGI: 1919519 HomoloGene: 1352 ChEMBL: 4502 GeneCards: CDA Gene
EC number	3.5.4.5
Gene ontology
Molecular function	• nucleoside binding; • cytidine deaminase activity; • protein binding; • zinc ion binding; • protein homodimerization activity;
Cellular component	• extracellular region; • cytosol;
Biological process	• pyrimidine nucleobase metabolic process; • cell surface receptor signaling pathway; • pyrimidine-containing compound salvage; • cytidine deamination; • cytosine metabolic process; • negative regulation of cell growth; • pyrimidine nucleoside salvage; • small molecule metabolic process; • negative regulation of nucleotide metabolic process; • protein homotetramerization; • nucleobase-containing small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;