cystic disease of the kidney

腎嚢胞

WordNet

1. a special situation; "this thing has got to end"; "it is a remarkable thing"
2. a separate and self-contained entity
3. an action; "how could you do such a thing?"
4. an artifact; "how does this thing work?"
5. an entity that is not named specifically; "I couldnt tell what the thing was"
6. any attribute or quality considered as having its own existence; "the thing I like about her is ..."
7. a persistent illogical feeling of desire or aversion; "he has a thing about seafood"; "she has a thing about him"
8. a special abstraction; "a thing of the spirit"; "things of the heart"
9. a special objective; "the thing is to stay in bounds"
10. a statement regarded as an object; "to say the same thing in other terms"; "how can you say such a thing?"
11. an event; "a funny thing happened on the way to the..."
12. an impairment of health or a condition of abnormal functioning
13. either of two bean-shaped excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine; "urine passes out of the kidney through ureters to the bladder"

PrepTutorEJDIC

1. 〈C〉(形のある)『物』,物体;(生物に対しての)『無生物』 / 〈C〉(形のない)『もの』,事,事柄,でき事 / 《複数形で》事情,事態,状勢,状況 / 《複数形で》(すべての)事物,事柄 / 《通例 the~》(努力・活動などの)目的,目標 / 〈C〉衣服,衣類・《one's things》持ち物,所持品,身の回り品 / 《複数形で》道具,用具・〈C〉《親愛・哀れみ・軽べつなどの感情をこめて》人,者,やつ / 《the~》《話》(…の)流行《+in+名》
2. 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
3. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
4. 女性の話術芸人 =diseur
5. 《前述の名詞または文脈でそれと分かる名詞に付けて》『その』,あの,名の / 《唯一の事物に付けて》 / 《方角・自然現象に付けて》 / 《用具・楽器・特定の病気などに付けて》 / 《修飾吾[句]を伴う名詞に付けて》 / 《単数普通名詞に付けて》(1)《種族全体》…『というもの』 / 《複数名詞または集合名詞に付けて》 / 《単位》『…につき;…単位[で]』 / 《身体の一部に付けて,所有格に代わる》 / 《形容詞に付けて》 / 《固有名詞に付けて》 / 《強意用法に》『随一の』,典型的な / 《「the+比較級,the+比較級」の形で》『…すればするほどそれだけ』 / 《比較級の前に》(…につれて,のために)『それだけ』,ますます
6. 腎臓;(食品としての)羊(豚など)の腎臓 / 《文》気質,性質,たち(nature)

UpToDate Contents

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• 1. Autosomal dominant tubulointerstitial kidney disease (medullary cystic kidney disease)
• 2. 成人における後天性腎嚢胞性疾患 acquired cystic disease of the kidney in adults
• 3. Diagnostic approach to the patient with newly identified chronic kidney disease
• 4. 糖尿病性腎症の概要 overview of diabetic nephropathy
• 5. Overview of renal disease associated with malignancy

English Journal

• Synovial sarcoma of the kidney: a clinicopathologic, immunohistochemical, and molecular genetic study of 16 cases.

• Schoolmeester JK, Cheville JC, Folpe AL.Author information Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.AbstractWe report the clinicopathologic and immunohistochemical features of 16 cases of genetically confirmed primary synovial sarcoma of the kidney. The cases occurred in 9 men and 7 women ranging in age from 17 to 78 years (mean, 46 y). The tumors were grossly large, solid, and variably cystic (2.2 to 19.0 cm; mean 8.6 cm). Microscopically, all tumors were of the monophasic type and diffusely immunoreactive for TLE1 and BCL-2. Focal pankeratin positivity was found in just under half. Ten cases carried an SS18-SSX2 fusion transcript, and 5 cases showed an SS18-SSX1 transcript by reverse transcription polymerase chain reaction. The remaining case demonstrated SS18 rearrangement by fluorescence in situ hybridization. Clinical follow-up information was available for 12 patients (range, 1 to 77 mo; mean, 32.5 mo). Fourteen patients underwent radical nephrectomy, and 3 patients had lung metastases at presentation. Six patients died of disease within 1 to 58 months (mean, 31 mo) of their diagnosis. Five patients were alive without evidence of disease 12 to 77 months (mean, 39 mos) after surgery. A single patient was alive with metastases to the spine 11 months after surgery. We conclude that renal synovial sarcoma is an aggressive tumor, with adverse patient outcome in >50% of cases. Synovial sarcoma must be distinguished from morphologically similar lesions of the kidney.
• The American journal of surgical pathology.Am J Surg Pathol.2014 Jan;38(1):60-5. doi: 10.1097/PAS.0b013e31829b2d0d.
• We report the clinicopathologic and immunohistochemical features of 16 cases of genetically confirmed primary synovial sarcoma of the kidney. The cases occurred in 9 men and 7 women ranging in age from 17 to 78 years (mean, 46 y). The tumors were grossly large, solid, and variably cystic (2.2 to 19.
• PMID 24061517

• Multiple cysts in kidneys: A case report.

• Kumar KV, Jha R, Shekhar S, Sunil K, Modi KD.Author information Department of Endocrinology, Medwin Hospitals, Nampally, Hyderabad, A.P., India.AbstractVon Hippel-Lindau (VHL) disease, which is an autosomal dominant inherited disease, is characterized by highly vascularized tumors in different organs. We report a 42-year-old male who presented to our hospital with diarrhea and weight loss of six months' duration. Ultrasonography of the abdomen revealed bilateral polycystic kidneys with multiple cystic and solid com-ponents as well as polycystic pancreas. A computerized tomography scan of the abdomen revealed bilateral multiple simple and complex renal cysts, cystic lesions in the head and body of the pancreas and a non-enhancing lesion in the left adrenal gland. The features raised the possibility of VHL syndrome and a biopsy of the kidney revealed atypical cells with a suspicion of malignancy. He underwent bilateral nephrectomy and is on maintenance dialysis since then.
• Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.Saudi J Kidney Dis Transpl.2014 Jan-Feb;25(1):126-9.
• Von Hippel-Lindau (VHL) disease, which is an autosomal dominant inherited disease, is characterized by highly vascularized tumors in different organs. We report a 42-year-old male who presented to our hospital with diarrhea and weight loss of six months' duration. Ultrasonography of the abdomen reve
• PMID 24434396

• Generation of AQP2-Cre transgenic mini-pigs specifically expressing Cre recombinase in kidney collecting duct cells.

• Luo W, Li Z, Huang Y, Han Y, Yao C, Duan X, Ouyang H, Li L.Author information College of Animal Science, Jilin University, 5333 Xi'an Road, Changchun, 130062, People's Republic of China.AbstractThe important differences in physiological parameters and anatomical characteristics of the kidney between humans and mice make it difficult to replicate the precise progression of human renal cystic diseases in gene modification mouse models. In contrast to mice, pigs are a better animal model of human diseases, as they are more similar in terms of organ size, structure, and physiological parameters. Here, we report the generation and initial examination of an AQP2-Cre transgenic (Tg) Chinese miniature (mini)-pig line that expresses Cre recombinase exclusively in kidney collecting duct cells. An 8-kb fragment of the mini-pig aquaporin 2 (AQP2) 5'-flanking region was utilized to direct Cre expression in Tg mini-pigs. Two Tg mini-pigs were generated by pig somatic cell nuclear transfer and both carried the entire coding sequence of Cre recombinase. RT-PCR and western blotting analysis revealed that Cre recombinase was uniquely expressed in the kidney, while immunohistochemical studies located its expression in kidney collecting duct cells. Furthermore, six integration sites and 12-14 copies of the Cre gene were detected in various tissues by high-efficiency thermal asymmetric interlaced PCR and absolute quantitative real-time PCR, respectively. Combined with previous studies of Cre recombinase activity, we believe that this AQP2-Cre Tg mini-pig line will be a useful tool to generate kidney collecting duct cell-specific gene knockout mini-pig models, thereby allowing the investigation of gene functions in kidney development and the mechanisms of human renal cystic disease.
• Transgenic research.Transgenic Res.2013 Dec 5. [Epub ahead of print]
• The important differences in physiological parameters and anatomical characteristics of the kidney between humans and mice make it difficult to replicate the precise progression of human renal cystic diseases in gene modification mouse models. In contrast to mice, pigs are a better animal model of h
• PMID 24307331

Japanese Journal

• 野生メダカに見出された嚢胞に関する病理組織学的所見

• 魚病研究 51(1), 8-14, 2016
• NAID 130005138645

• 当院における一年間の健診腹部超音波検査の現状について

• 医学検査 65(1), 103-109, 2016
• NAID 130005133689

• 囊胞性腎疾患 (特集 遺伝性腎疾患)

• The
• NAID 40020503227

Related Links

• Cystic Diseases of the Kidney: Background, Pathophysiology ...

One third of people older than 50 years develop renal cysts. Although most are simple cysts, renal cystic disease has multiple etiologies. ... Developmental cystic renal disease Multicystic dysplastic kidney (MCDK) is ...

• Polycystic kidney disease - Mayo Clinic

Polycystic kidney disease — Comprehensive overview covers symptoms, treatment, prevention of this kidney condition. ... Mayo Clinic in Minnesota has been recognized as the best Nephrology hospital in the nation for 2015-2016 by ...

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★リンクテーブル★

リンク元	「腎嚢胞」
関連記事	「disease」「thing」「cystic」「kidney」

「腎嚢胞」

　　[★]

英

renal cyst, cystic disease of the kidney

• 常染色体優性多発性嚢胞腎 autosomal dominant polycystic kidney disease ADPKD
• 常染色体劣性多発性嚢胞腎 autosomal recessive polycystic kidney disease ARPKD

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「thing」

　　[★] 　 　 　 　 　 　 　 　 　 　 　 　

「cystic」

　　[★]

• adj.

• 嚢胞性の

　 　 　

「kidney」

　　[★] 腎臓

同

KUB