塩酸シクロペントラート、塩酸シクロペントレート

関: cyclopentolate

WordNet

a complex consisting of an organic base in association with hydrogen chloride

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/29 19:50:34」(JST)

wiki en

Cyclopentolate is a medication commonly used during pediatric eye examinations that dilates the eye (mydriatic), prevents accommodation of the eye to different distances (cycloplegic), and blocks specific receptors called muscarinic receptors (muscarinic antagonist).^[1] Cyclopentolate is also administered as an atropine substitute to reverse muscarinic and central nervous system effects of indirect cholinomimetic (anti-AChase) administration.

When used in eye drops in pediatric eye examinations, cyclopentolate 0.5 percent and 1.0 percent is used to stop the eye focusing at near distance, enabling the ophthalmologist and optometrist to obtain a more accurate reading of the focusing power of the eyes. Brand names include Cyclogyl, Cylate, & Pentolair.^[2]

The drops take around 30-60 minutes to work and less than 24 hours to wear off (with patients advised not to drive a vehicle or operate machinery for the first 12 hours). The pupils become wider when cyclopentolate is administered, making the eyes more sensitive to light. Close objects (and possibly distant objects) will also appear blurred.

Side effects to cyclopentolate are rare, but can include effects such as disorientation, incoherent speech or visual disturbances during the 24-hour period that the drug has an effect. The side effects are more common in children.

Pupil dilation (mydriasis) caused by cyclopentolate 1% instilled into both eyes

References

^ "Cyclopentolate". Retrieved June 15, 2012.
^ "cyclopentolate hydrochloride solution - ophthalmic, Cyclogyl, Cylate, Pentolair". Retrieved June 15, 2012.
^ John P.Whitcher, Paul Riordan-Eva. Vaughan & Asbury's general ophthalmology. (17th ed. ed.). McGraw-Hill Medical. p. 63. ISBN 978-0071443142.

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English Journal

Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children.

Hiraoka T1, Miyata K2, Nakamura Y2, Ogata M2, Okamoto F1, Oshika T1.
Eye (London, England).Eye (Lond).2014 May;28(5):581-6. doi: 10.1038/eye.2014.34. Epub 2014 Feb 28.
PurposeTo investigate the influence of cycloplegia with topical cyclopentolate on wavefront aberrations in myopic children.DesignThis is a prospective, comparative study.MethodsTwenty-eight myopic children with a mean age of 7.25±2.55 were enrolled in this study. We evaluated refraction and wavefro
PMID 24577253

Effects of the cycloplegic, cyclopentolate, on measurements of refraction in eyes of a strain of wild-type juvenile guinea pig (Cavia porcellus): a comparative study.

Zhou J1, Pan M, Chen G, Zhen J, Xie R, Lu F, Qu J.
Current eye research.Curr Eye Res.2014 Apr;39(4):416-20. doi: 10.3109/02713683.2013.845226. Epub 2013 Nov 11.
OBJECTIVE: To investigate the effect(s) of the cycloplegic, cyclopentolate, on measurements of refraction in eyes of a strain of wild-type guinea pig.METHODS: Both eyes of 13 wild-type juvenile guinea pigs (n=26 eyes) were examined both pre- and post-mydriasis, using streak retinoscopy (SR) and ecce
PMID 24215558

Epileptic seizures induced by cycloplegic eye drops.

Wygnanski-Jaffe T1, Nucci P, Goldchmit M, Mezer E.
Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2013 Jul 2. [Epub ahead of print]
Abstract Objective: To assess the incidence of seizures induced by cycloplegic ophthalmic drops. Materials and methods: A survey among members of the American Association for Pediatric Ophthalmology and Strabismus yielded five patients who received cycloplegic eye drops between 1998 and 2010 and who
PMID 23815170

Japanese Journal

成人における1%塩酸シクロペントレート点眼を用いた調節麻痺屈折検査の評価

安里崇徳,小島隆司,片岡嵩博,井藤麻由香,洞井里絵,中村友昭,渡部環,佐藤裕也,白井優太,佐藤知美,玉置明野,市川一夫
IOL & RS : Japanese journal of cataract and refractive surgery : 日本眼内レンズ屈折手術学会誌 26(2), 197-201, 2012-06-15
NAID 10030791372

学童期の軽度近視のトロピカミド点眼療法

篠原眞美,橋本禎子,八子恵子
日本眼科紀要 = Folia ophthalmologica Japonica 49(8), 685-689, 1998-08-28
NAID 10009732083

1% Cyclopentolate hydrochloride : another look at the time course of cycloplegia using an objective measure of the accommodative response

MANNY RE
Optom Vis Sci 70, 651-665, 1993
NAID 30009488313

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★リンクテーブル★

リンク元	「シクロペントレート」「塩酸シクロペントラート」「塩酸シクロペントレート」
関連記事	「hydrochloride」「cyclopentolate」

「シクロペントレート」

Cyclopentolate
Systematic (IUPAC) name
	2-(dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate
Clinical data
Pregnancy; category	C;
Routes of; administration	Topic
Identifiers
CAS Registry Number	512-15-2
ATC code	S01FA04
PubChem	CID: 2905
DrugBank	DB00979
ChemSpider	2802
UNII	I76F4SHP7J
KEGG	D07759
ChEBI	CHEBI:4024
ChEMBL	CHEMBL1200473
Chemical data
Formula	C17H25NO3
Molecular mass	291.385 g/mol
	SMILES O=C(OCCN(C)C)C(c1ccccc1)C2(O)CCCC2 ;
	InChI InChI=1S/C17H25NO3/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3 ; Key:SKYSRIRYMSLOIN-UHFFFAOYSA-N ;
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　　[★]

英: cyclopentolate、cyclopentolate hydrochloride
関: シクロペントラート、塩酸シクロペントラート、塩酸シクロペントレート

「塩酸シクロペントラート」

　　[★]

英: cyclopentolate hydrochloride
関: シクロペントレート、シクロペントラート、塩酸シクロペントレート

「塩酸シクロペントレート」

　　[★]

英: cyclopentolate hydrochloride
関: シクロペントレート、シクロペントラート、塩酸シクロペントラート

「hydrochloride」

　　[★] 塩酸塩、ハイドロクロライド　

「cyclopentolate」

　　[★] シクロペントラート

[1] "Cyclopentolate". Retrieved June 15, 2012.

[2] "cyclopentolate hydrochloride solution - ophthalmic, Cyclogyl, Cylate, Pentolair". Retrieved June 15, 2012.

[vaughan-3] John P.Whitcher, Paul Riordan-Eva. Vaughan & Asbury's general ophthalmology. (17th ed. ed.). McGraw-Hill Medical. p. 63. ISBN 978-0071443142.

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案内

案内

cyclopentolate hydrochloride