cyclopenthiazide

シクロペンチアジド

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/05 15:41:55」(JST)

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Cyclopenthiazide

Systematic (IUPAC) name
6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status
Legal status	UK: POM (Prescription only)
Identifiers
CAS Number	742-20-1
ATC code	C03AA07 (WHO)
PubChem	CID 2904
IUPHAR/BPS	7899
ChemSpider	2801
UNII	VX4S2N85F5 Y
KEGG	D02061 Y
ChEMBL	CHEMBL1373254
Chemical data
Formula	C13H18ClN3O4S2
Molar mass	379.88 g/mol
SMILES O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)NC(N2)CC3CCCC3)N
InChI InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19) Key:BKYKPTRYDKTTJY-UHFFFAOYSA-N
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Cyclopenthiazide (trade name Navidrex) is a thiazide diuretic used in the treatment of heart failure and hypertension.

Synthesis

Cyclopenthiazide synthesis:

Contraindications

Thiazide diuretics increase the excretion of sodium and potassium ions and decrease the excretion of calcium ions and uric acid so they are contraindicated in patients with hyponatraemia, hypokalaemia, hypercalcaemia and hyperuricaemia. They are also contraindicated in patients with Addison's disease.

See also

• Cyclothiazide
• Hydrochlorothiazide
• Bendroflumethiazide

References

English Journal

• Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension.

• Musini VM1, Nazer M, Bassett K, Wright JM.
• The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2014 May 29;5:CD003824. doi: 10.1002/14651858.CD003824.pub2.
• BACKGROUND: Hypertension is a modifiable cardiovascular risk factor. Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity, the dose-related effect of thiazides in decreasing blood pressure has not been subject to a rigorous systematic review. It is
• PMID 24869750

• A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling.

• Sadanandam A1, Futakuchi M, Lyssiotis CA, Gibb WJ, Singh RK.
• BMC cancer.BMC Cancer.2011 Jul 20;11:304. doi: 10.1186/1471-2407-11-304.
• BACKGROUND: Breast cancer is the second leading cause of cancer-related death in women in the United States. During the advanced stages of disease, many breast cancer patients suffer from bone metastasis. These metastases are predominantly osteolytic and develop when tumor cells interact with bone.
• PMID 21774828

• Drug-induced pancreatitis: an update.

• Trivedi CD1, Pitchumoni CS.
• Journal of clinical gastroenterology.J Clin Gastroenterol.2005 Sep;39(8):709-16.
• BACKGROUND AND AIMS: Many frequently prescribed drugs are suspected to cause acute pancreatitis (AP). The goal of this paper is to bring to light the often occult but real problem of drug-induced pancreatitis (DIP).METHODS: We searched the National Library of Medicine/Pubmed for reported cases of DI
• PMID 16082282

Japanese Journal

• Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspilin-like analgesics and cyclopenthiazide

• HARDING JJ
• Br J Ophthalmol 72, 809-814, 1992
• NAID 30029614939

• 低ナトリウム食飼育ラットにおけるThiazide系利尿薬の尿酸排泄抑制作用

• 岩木 一巳,米谷 行男
• 日本薬理学雑誌 85(3), 119-127, 1985
• … 酸のfractional excretion値の低下に基づく尿酸の排泄抑制が発現し，2 mg/kgでは糸球体濾過率の低下に基づく尿酸の排泄抑制がこれに加味された．同様の尿酸排泄抑制作用は，hydrochlorothiazide(10 mg/kg, p.o.)およびcyclopenthiazide(0.5 mg/kg, p.o.)処置によっても発現した．いずれの薬物投与においてもヘマトクリット値は顕著に上昇し血漿カリウム濃度は低下した．ナトリウム摂取の制限下にtrichlormethiazideを連用したラットにおいては …
• NAID 130000761758

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cyclopenthiazide

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チアジド系利尿薬