- 同
- CDK9＆Tat protein binding
- 同
- CDK9＆Tat protein binding
WordNet
- relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
- addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
- contingent on something else (同)dependant, qualified
- (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- the basic unit of money in Papua New Guinea
PrepTutorEJDIC
- 『頼っている』,依存している,従属している / 扶養される人(家族)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/29 21:48:00」(JST)
[Wiki en表示]
| Cyclin-dependent kinase 9 |
|
Rendering based on PDB 1PF6.
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| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
1PF6, 3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCI, 4BCJ, 4EC8, 4EC9, 4IMY, 4OGR, 4OR5
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|
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| Identifiers |
| Symbols |
CDK9 ; C-2k; CDC2L4; CTK1; PITALRE; TAK |
| External IDs |
OMIM: 603251 MGI: 1328368 HomoloGene: 55566 ChEMBL: 3116 GeneCards: CDK9 Gene |
| EC number |
2.7.11.22, 2.7.11.23 |
| Gene ontology |
| Molecular function |
• DNA binding
• chromatin binding
• protein kinase activity
• cyclin-dependent protein serine/threonine kinase activity
• protein binding
• ATP binding
• transcription factor binding
• RNA polymerase II carboxy-terminal domain kinase activity
• snRNA binding
• transcription regulatory region DNA binding
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| Cellular component |
• nucleoplasm
• cytoplasm
• transcription elongation factor complex
• positive transcription elongation factor complex b
• membrane
• PML body
• intracellular membrane-bounded organelle
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| Biological process |
• DNA repair
• regulation of DNA repair
• transcription, DNA-templated
• transcription from RNA polymerase II promoter
• transcription initiation from RNA polymerase II promoter
• transcription elongation from RNA polymerase II promoter
• protein phosphorylation
• transforming growth factor beta receptor signaling pathway
• regulation of mitotic cell cycle
• cell proliferation
• gene expression
• positive regulation of cardiac muscle hypertrophy
• viral process
• regulation of histone modification
• replication fork processing
• positive regulation of histone phosphorylation
• response to drug
• positive regulation of transcription from RNA polymerase II promoter
• positive regulation of viral transcription
• negative regulation of cell cycle arrest
• cellular response to cytokine stimulus
• negative regulation of mRNA polyadenylation
• positive regulation of mRNA 3'-UTR binding
• positive regulation of histone H2B ubiquitination
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
1025 |
107951 |
| Ensembl |
ENSG00000136807 |
ENSMUSG00000009555 |
| UniProt |
P50750 |
Q99J95 |
| RefSeq (mRNA) |
NM_001261 |
NM_130860 |
| RefSeq (protein) |
NP_001252 |
NP_570930 |
| Location (UCSC) |
Chr 9:
127.79 – 127.79 Mb |
Chr 2:
32.71 – 32.71 Mb |
| PubMed search |
[1] |
[2] |
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Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb.
Contents
- 1 Function
- 2 Interactions
- 3 References
- 4 Further reading
- 5 External links
Function
The protein encoded by this gene is a member of the cyclin-dependent kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.[1]
CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle.[2]
Interactions
CDK9 has been shown to interact with:
- Androgen receptor,[3]
- CDC34[4] and
- CCNK,[5]
- CCNT1,[5][6][7][8][9][10][4][11][12]
- CCNT2,[6]
- MYBL2,[11]
- RELA,[13]
- RB1,[14]
- SKP1A,[4] and
- SUPT5H.[12]
References
- ^ "Entrez Gene: CDK9 cyclin-dependent kinase 9 (CDC2-related kinase)".
- ^ MacLachlan TK, Sang N, De Luca A, Puri PL, Levrero M, Giordano A (1998). "Binding of CDK9 to TRAF2". J. Cell. Biochem. 71 (4): 467–78. doi:10.1002/(SICI)1097-4644(19981215)71:4<467::AID-JCB2>3.0.CO;2-G. PMID 9827693.
- ^ Lee DK, Duan HO, Chang C (March 2001). "Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation". J. Biol. Chem. 276 (13): 9978–84. doi:10.1074/jbc.M002285200. PMID 11266437.
- ^ a b c Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, Nakayama Ki K, Benkirane M (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
- ^ a b Fu TJ, Peng J, Lee G, Price DH, Flores O (December 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". J. Biol. Chem. 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912.
- ^ a b Peng J, Zhu Y, Milton JT, Price DH (March 1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev. 12 (5): 755–62. doi:10.1101/gad.12.5.755. PMC 316581. PMID 9499409.
- ^ Cabart P, Chew HK, Murphy S (July 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.
- ^ Young TM, Wang Q, Pe'ery T, Mathews MB (September 2003). "The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (18): 6373–84. doi:10.1128/MCB.23.18.6373-6384.2003. PMC 193714. PMID 12944466.
- ^ Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (July 2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol. Cell. Biol. 23 (14): 4859–69. doi:10.1128/MCB.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
- ^ Hoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T (March 2003). "The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription". Mol. Cell. Biol. 23 (5): 1688–702. doi:10.1128/MCB.23.5.1688-1702.2003. PMC 151712. PMID 12588988.
- ^ a b De Falco G, Bagella L, Claudio PP, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A (January 2000). "Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation". Oncogene 19 (3): 373–9. doi:10.1038/sj.onc.1203305. PMID 10656684.
- ^ a b Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (September 2000). "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Mol. Cell. Biol. 20 (18): 6958–69. doi:10.1128/MCB.20.18.6958-6969.2000. PMC 88771. PMID 10958691.
- ^ Amini S, Clavo A, Nadraga Y, Giordano A, Khalili K, Sawaya BE (August 2002). "Interplay between cdk9 and NF-kappaB factors determines the level of HIV-1 gene transcription in astrocytic cells". Oncogene 21 (37): 5797–803. doi:10.1038/sj.onc.1205754. PMID 12173051.
- ^ Simone C, Bagella L, Bellan C, Giordano A (June 2002). "Physical interaction between pRb and cdk9/cyclinT2 complex". Oncogene 21 (26): 4158–65. doi:10.1038/sj.onc.1205511. PMID 12037672.
Further reading
- Jeang KT (1998). "Tat, Tat-associated kinase, and transcription.". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
- Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation.". Curr. Biol. 8 (13): R447–9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670.
- Romano G, Kasten M, De Falco G; et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression.". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359.
- Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator.". IUBMB Life 51 (3): 175–81. doi:10.1080/152165401753544241. PMID 11547919.
- Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection.". Eur. J. Clin. Invest. 34 (1): 57–66. doi:10.1111/j.1365-2362.2004.01282.x. PMID 14984439.
- Rice AP, Herrmann CH (2004). "Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages.". Curr. HIV Res. 1 (4): 395–404. doi:10.2174/1570162033485159. PMID 15049426.
- Minghetti L, Visentin S, Patrizio M; et al. (2004). "Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions.". Neurochem. Res. 29 (5): 965–78. doi:10.1023/B:NERE.0000021241.90133.89. PMID 15139295.
- Liou LY, Herrmann CH, Rice AP (2005). "HIV-1 infection and regulation of Tat function in macrophages.". Int. J. Biochem. Cell Biol. 36 (9): 1767–75. doi:10.1016/j.biocel.2004.02.018. PMID 15183343.
- Pugliese A, Vidotto V, Beltramo T; et al. (2005). "A review of HIV-1 Tat protein biological effects.". Cell Biochem. Funct. 23 (4): 223–7. doi:10.1002/cbf.1147. PMID 15473004.
- Bannwarth S, Gatignol A (2005). "HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.". Curr. HIV Res. 3 (1): 61–71. doi:10.2174/1570162052772924. PMID 15638724.
- Gibellini D, Vitone F, Schiavone P, Re MC (2005). "HIV-1 tat protein and cell proliferation and survival: a brief review.". New Microbiol. 28 (2): 95–109. PMID 16035254.
- Peruzzi F (2006). "The multiple functions of HIV-1 Tat: proliferation versus apoptosis.". Front. Biosci. 11: 708–17. doi:10.2741/1829. PMID 16146763.
External links
- Cyclin-Dependent Kinase 9 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Drosophila Cyclin dependent kinase 9 - The Interactive Fly
- CDK9 human gene location in the UCSC Genome Browser.
- CDK9 human gene details in the UCSC Genome Browser.
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Cell cycle proteins
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| Cyclin |
- A (A1, A2)
- B (B1, B2, B3)
- D (D1, D2, D3)
- E (E1, E2)
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| CDK |
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- CDK-activating kinase
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| CDK inhibitor |
- INK4a/ARF (p14arf/p16, p15, p18, p19)
- cip/kip (p21, p27, p57)
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| P53 p63 p73 family |
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| Other |
- Cdc2
- Cdc25
- Cdc42
- Cellular apoptosis susceptibility protein
- E2F
- Maturation promoting factor
- Wee
- Cullin (CUL7)
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Phases and
checkpoints |
| Interphase |
- G1 phase
- S phase
- G2 phase
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| M phase |
- Mitosis (Preprophase
- Prophase
- Prometaphase
- Metaphase
- Anaphase
- Telophase)
- Cytokinesis
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| Cell cycle checkpoints |
- Restriction point
- Spindle checkpoint
- Postreplication checkpoint
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| Other cellular phases |
- Apoptosis
- G0 phase
- Meiosis
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Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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| Polo kinase (EC 2.7.11.21) |
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| Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDK12
- CDC2L5
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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| (RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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| Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
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| MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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| Tau-protein kinase (EC 2.7.11.26) |
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| (acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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| Tropomyosin kinase (EC 2.7.11.28) |
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| Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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| Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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| MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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Enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction.
- Zhu R1, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr.
- Biochemistry.Biochemistry.2014 Mar 25;53(11):1753-67. doi: 10.1021/bi5000178. Epub 2014 Mar 11.
- A gene induction competition assay has recently uncovered new inhibitory activities of two transcriptional cofactors, NELF-A and NELF-B, in glucocorticoid-regulated transactivation. NELF-A and -B are also components of the NELF complex, which participates in RNA polymerase II pausing shortly after t
- PMID 24559102
- Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1.
- Lemke J1, von Karstedt S2, Abd El Hay M2, Conti A3, Arce F4, Montinaro A2, Papenfuss K2, El-Bahrawy MA5, Walczak H2.
- Cell death and differentiation.Cell Death Differ.2014 Mar;21(3):491-502. doi: 10.1038/cdd.2013.179. Epub 2013 Dec 20.
- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in many cancer cells without causing toxicity in vivo. However, to date, TRAIL-receptor agonists have only shown limited therapeutic benefit in clinical trials. This can, most likely, be attributed to the fact that
- PMID 24362439
- A phase I trial of flavopiridol in relapsed multiple myeloma.
- Hofmeister CC1, Poi M, Bowers MA, Zhao W, Phelps MA, Benson DM, Kraut EH, Farag S, Efebera YA, Sexton J, Lin TS, Grever M, Byrd JC.
- Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2014 Feb;73(2):249-57. doi: 10.1007/s00280-013-2347-y. Epub 2013 Nov 16.
- PURPOSE: Flavopiridol is primarily a cyclin-dependent kinase-9 inhibitor, and we performed a dose escalation trial to determine the maximum tolerated dose and safety and generate a pharmacokinetic (PK) profile.METHODS: Patients with a diagnosis of relapsed myeloma after at least two prior treatments
- PMID 24241210
Japanese Journal
- ETS-related transcription factors Etv4 and Etv5 are involved in proliferation and induction of differentiationassociated genes in embryonic stem (ES) cells
- 乳がん領域における開発中の薬剤 : CDK4/6阻害剤 (特集 早期乳がんおよび進行乳がんに対する新しい標準治療の開発)
- The role of signaling pathways on proliferation and self-renewal of cultured bovine primitive germ cells
Related Links
- Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive ...
- The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important ...
Related Pictures
★リンクテーブル★
[★]
- 英
- cyclin-dependent kinase 9
[★]
- 関
- depend、dependence、dependency、dependently
[★]
キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
[★]