出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/11 11:09:41」(JST)
Cyclin-dependent kinase 2 | |||||||||||||
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PDB rendering based on 1aq1[1]. |
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Identifiers | |||||||||||||
Symbols | CDK2; p33(CDK2) | ||||||||||||
External IDs | OMIM: 116953 MGI: 104772 HomoloGene: 74409 ChEMBL: 301 GeneCards: CDK2 Gene | ||||||||||||
EC number | 2.7.11.22 | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 1017 | 12566 | |||||||||||
Ensembl | ENSG00000123374 | ENSMUSG00000025358 | |||||||||||
UniProt | P24941 | P97377 | |||||||||||
RefSeq (mRNA) | NM_001798 | NM_016756 | |||||||||||
RefSeq (protein) | NP_001789 | NP_058036 | |||||||||||
Location (UCSC) | Chr 12: 56.36 – 56.37 Mb |
Chr 10: 128.7 – 128.71 Mb |
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PubMed search | [1] | [2] | |||||||||||
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Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.[2][3]
The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the G1/S transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.[3]
The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition.[4]
Known CDK inhibitors are p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B).[5] Drugs that inhibit Cdk2 and arrest the cell cycle, such as GW8510 and the experimental cancer drug seliciclib, may reduce the sensitivity of the epithelium to many cell cycle-active antitumor agents and, therefore, represent a strategy for prevention of chemotherapy-induced alopecia.[6]
In melanocytic cell types, expression of the CDK2 gene is regulated by the Microphthalmia-associated transcription factor.[7][8]
Cyclin-dependent kinase 2 has been shown to interact with Retinoblastoma-like protein 2,[9][10] Retinoblastoma-like protein 1,[9][11] Flap structure-specific endonuclease 1,[12] CEBPA,[13] BRCA1,[14][15][16] PPM1B,[17] Cyclin A1,[18][19][20][21] Cyclin E1,[9][22][23][24][25][26] SKP2,[27][28][29] PPP2CA,[17] ORC1L,[30] CDK2AP1,[31] CDKN3,[32][33][34] CDKN1B[25][27][35][36][37] and P21.[22][29][34][37][38]
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リンク元 | 「サイクリン依存性キナーゼ2」 |
関連記事 | 「dependent」「kinase」「dependent kinase」 |
[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
.