WordNet

of a compound having atoms arranged in a ring structure
recurring in cycles (同)cyclical
conforming to the Carnot cycle
forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
marked by repeated cycles
any of the carbohydrates that yield only a few monosaccharide molecules on complete hydrolysis

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 重症患者における神経筋遮断剤の使用 use of neuromuscular blocking medications in critically ill patients
2. 周期性嘔吐症候群 cyclic vomiting syndrome
3. 周期性好中球減少症 cyclic neutropenia
4. 男性性機能障害の概要 overview of male sexual dysfunction
5. 小児における片頭痛の分類 classification of migraine in children

English Journal

Tailored functionalization of ZnO nanoparticle via reactive cyclodextrin and its bionanocomposite synthesis.

Abdolmaleki A1, Mallakpour S2, Borandeh S3.Author information 1Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran; Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran. Electronic address: abdolmaleki@cc.iut.ac.ir.2Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran; Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran. Electronic address: mallak@cc.iut.ac.ir.3Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Islamic Republic of Iran.Abstractβ-cyclodextrin was grafted onto the surface of ZnO nanoparticles via efficient, simple and fast technique through nucleophilic substitution reaction of OH groups on ZnO nanoparticle surface with reactive cyclic oligosaccharide, Monochlorotriazinyl-β-cyclodextrin (MCT-β-CD). Characterization of functionalized ZnO nanoparticles were carried out by Fourier transform infrared spectra (FT-IR), elemental analysis (CHN), Thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM). The amount of MCT-β-CD bonded to the ZnO surface was determined by CHN and TGA analysis. Followed by, innovative poly(ester-amide)/ZnO bionanocomposites (PEA/ZnO BNCs) were fabricated through solution mixing method. Due to using biodegradable amino acid containing polymer, the synthesized nanocomposites are expected to classify as biologically active materials. Morphological studies of prepared BNC proved good distribution of modified ZnO in PEA matrix with nanoscale size. Good dispersion and less aggregation, indicate the effect of functionalization on preventing nanoparticles to aggregate.
Carbohydrate polymers.Carbohydr Polym.2014 Mar 15;103:32-7. doi: 10.1016/j.carbpol.2013.12.013. Epub 2013 Dec 12.
β-cyclodextrin was grafted onto the surface of ZnO nanoparticles via efficient, simple and fast technique through nucleophilic substitution reaction of OH groups on ZnO nanoparticle surface with reactive cyclic oligosaccharide, Monochlorotriazinyl-β-cyclodextrin (MCT-β-CD). Characterization of fu
PMID 24528697

Neuroprotective Effects of 3,6'-Disinapoyl Sucrose Through Increased BDNF Levels and CREB Phosphorylation via the CaMKII and ERK1/2 Pathway.

Hu Y1, Liu MY, Liu P, Dong X, Boran AD.Author information 1Department of Clinical Pharmacology, Pharmacy Care Center, Chinese PLA General Hospital, No. 28 FuXing Road, Beijing, 100853, People's Republic of China.Abstract3,6'-Disinapoyl sucrose (DISS) is an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia. Our previous reports suggested that DISS can have neuroprotective effects and antidepressive activity in rats, at least in part, by increased expression of cyclic AMP response element (CRE)-binding protein (CREB) and its downstream target protein, brain-derived neurotrophic factor (BDNF). The aim of the present study was to explore the mechanism of DISS-modulated BDNF and CREB expression. In this study, we confirmed its neuroprotective effect by showing that DISS, at concentrations above 30 μM, could promote the neuron cell viability and protected the glutamate and H2O2-induced toxicity in the human neuroblastoma (SH-SY5Y) cell line. DISS treatment also increased acute (from 15 to 30 min) BDNF expression and CREB phosphorylation in a dose-dependent manner. Pharmacological inhibition of mitogen-activated protein kinase 1 (ERK1/2), CaMKII, and Trk (with U0126, KN93, or K252a, respectively) partially attenuated the stimulatory effect of DISS on phospho-CREB and BDNF expression; however, it was not inhibited by pharmacological inhibition of PKA or PI3K (with H89 and LY294002, respectively). The results are consistent with the effects of DISS on CRE-directed gene transcription, as U0126 and KN-93 treatment also blocked the DISS-induced expression of the CRE-luciferase reporter gene. The results from the present study suggest that DISS-mediated regulation of BDNF gene expression is associated with CREB-mediated transcription of BDNF and upstream activation of ERK1/2 and CaMKII. Finally, DISS may exert neuroprotective and antidepressant effects through these signaling pathways in neuronal cells.
Journal of molecular neuroscience : MN.J Mol Neurosci.2014 Feb 4. [Epub ahead of print]
3,6'-Disinapoyl sucrose (DISS) is an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia. Our previous reports suggested that DISS can have neuroprotective effects and antidepressive activity in rats, at least in part, by increased expression of cyclic AMP res
PMID 24488601

Editorial: natural & synthetically-modified cyclodextrins and polymers in drug delivery systems.

Otero-Espinar FJ, Blanco-Mendez J1.Author information 1University of Santiago de Compostela. Departamento de Farmacia y Tecnología Farmaceutica, Facultad de Farmacia s/n, Campus Vida, 15782 Santiago de Compostela, Spain. francisco.otero@usc.es.AbstractCyclodextrins are natural cyclic oligosaccharides that play a relevant role in different fields as pharmacy, medicine, chemistry, material, food or agricultural science. From the point of view of pharmaceutical and medical applications cyclodextrins have interest for their ability to form inclusion complexes with different host molecules as drugs. In the pharmaceutical industry, cyclodextrins has been used classically as solubilizes of hydrophobic drugs or as stabilizers of some labile molecules but can also offer interesting possibilities for drug control release of both hydrophobic and hydrophilic drugs. New and interesting perspectives for their use is being developed in recent years by the development of novel cyclodextrin derivatives including the polymeric one. The proposed topic for this special number of CTMC aims to provide new successes, challenges and recent advances on the design and applications of new CDs derivatives into the biomedical and pharmaceutical field .
Current topics in medicinal chemistry.Curr Top Med Chem.2014 Feb;14(4):463-4.
Cyclodextrins are natural cyclic oligosaccharides that play a relevant role in different fields as pharmacy, medicine, chemistry, material, food or agricultural science. From the point of view of pharmaceutical and medical applications cyclodextrins have interest for their ability to form inclusion
PMID 24354673