WordNet
- a straight line that generates a cylinder or cone
- one of four substances thought in ancient and medieval cosmology to constitute the physical universe; "the alchemists believed that there were four elements"
- the situation in which you are happiest and most effective; "in your element"
- the most favorable environment for a plant or animal; "water is the element of fishes"
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- a result; "this situation developed in response to events in Africa"
- a phrase recited or sung by the congregation following a versicle by the priest or minister
- the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
- of a compound having atoms arranged in a ring structure
- recurring in cycles (同)cyclical
- conforming to the Carnot cycle
- forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
- marked by repeated cycles
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 〈C〉(物質を構成する)元素 / 〈C〉《修飾語[句]を伴って》(…の)(基本的な)『要素』,『成分』;《しばしば複数形で》構成分子 / 〈C〉(生物に固有の)生息場所,環境;(人の)適所,本領 / 〈C〉《古》四大(しだい)[元素](自然界の基本的構成要素と考えられていた地(earth)・水(water)・風(air)・火(fire)の4大要素の一つ) / 《the elements》(雨・風・雪などの)自然力・風雨,(特に)悪天候 / 《the elements》(学問の)原理,初歩,概論
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
- 蛋白(たんばく)質
UpToDate Contents
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- 1. ステロイド抵抗性喘息 glucocorticoid resistant asthma
- 2. 甲状腺ホルモンの作用 thyroid hormone action
- 3. 赤血球産生調節 regulation of erythropoiesis
- 4. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
- 5. 喘息における吸入ステロイドの分子学的影響 molecular effects of inhaled glucocorticoid therapy in asthma
English Journal
- An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H.
- Barbosa S1, Fasanella G, Carreira S, Llarena M, Fox R, Barreca C, Andrew D, O'Hare P.Author information 1Department of Medicine, Imperial College, London, W2 1PG, UK.AbstractCREB3 proteins comprise a set of ER-localized bZip transcription factors defined by the presence of a transmembrane domain. They are regulated by inter-compartmental transport, Golgi cleavage and nuclear transport where they promote appropriate transcriptional responses. Although CREB3 proteins play key roles in differentiation, inflammation and metabolism, a general framework relating their defining features to these diverse activities is lacking. We identify unique features of CREB3 organization including the ATB domain, which we show it is essential for transcriptional activity. This domain is absent in all other human bZip factors, but conserved in Drosophila CREBA, which controls secretory pathway genes (SPGs). Furthermore, each of the five human CREB3 factors was capable of activating SPGs in Drosophila, dependent upon the ATB domain. Expression of the CREB3 protein, CREB-H, in 293 cells, upregulated genes involved in secretory capacity, extracellular matrix formation and lipid metabolism and increased secretion of specific cargos. In liver cells, which normally express CREB-H, the active form specifically induced secretion of apolipoproteins, including ApoA-IV, ApoAI, consistent with data implicating CREB-H in metabolic homeostasis. Based on these data and other recent studies, we propose a general role for the CREB3 family in regulating secretory capacity, with particular relevance to specialized cargos.
- Traffic (Copenhagen, Denmark).Traffic.2013 Apr;14(4):382-98. doi: 10.1111/tra.12038. Epub 2013 Jan 24.
- CREB3 proteins comprise a set of ER-localized bZip transcription factors defined by the presence of a transmembrane domain. They are regulated by inter-compartmental transport, Golgi cleavage and nuclear transport where they promote appropriate transcriptional responses. Although CREB3 proteins play
- PMID 23279168
- Functional genetic characterization of salivary gland development in Aedes aegypti.
- Nguyen C1, Andrews E, Le C, Sun L, Annan Z, Clemons A, Severson DW, Duman-Scheel M.Author information 1University of Notre Dame, Notre Dame, Eck Institute for Global Health and Department of Biological Sciences, Notre Dame, IN 46556, USA. mscheel@nd.edu.AbstractBACKGROUND: Despite the devastating global impact of mosquito-borne illnesses on human health, very little is known about mosquito developmental biology. In this investigation, functional genetic analysis of embryonic salivary gland development was performed in Aedes aegypti, the dengue and yellow fever vector and an emerging model for vector mosquito development. Although embryonic salivary gland development has been well studied in Drosophila melanogaster, little is known about this process in mosquitoes or other arthropods.
- EvoDevo.Evodevo.2013 Mar 6;4(1):9. doi: 10.1186/2041-9139-4-9.
- BACKGROUND: Despite the devastating global impact of mosquito-borne illnesses on human health, very little is known about mosquito developmental biology. In this investigation, functional genetic analysis of embryonic salivary gland development was performed in Aedes aegypti, the dengue and yellow f
- PMID 23497573
- CREB5 computational regulation network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients.
- Wang L1, Huang J, Jiang M.Author information 1Biomedical Center, School of Electronics Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China. wanglin98@tsinghua.org.cnAbstractCREB5 computational regulation network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy. By integration of gene regulatory network infer and the database for annotation, visualization and integrated discovery we identified and constructed significant molecule CREB5 regulation network from 12 frontal cortex of HIVE-control patients and 16 HIVE in the same GEO Dataset GDS1726. Our result verified CREB5 biological regulation module in the upstream of frontal cortex of HIVE-control patients (MAPKAPK3 activation; DGKG, LY96, TNFRSF11B inhibition) and downstream (ATP6V0E1, CFB, DGKG, MX1, TGFBR3 activation; LGALS3BP, RASGRP3, RDX, STAT1 inhibition), whereas in the upstream of frontal cortex of HIVE (BST2, CFB, LCAT, TNFRSF11B activation; CFHR1, LY96 inhibition) and downstream (GAS1, LCAT, LGALS3BP, NFAT5, VEZF1, ZNF652 activation; DGKG, IFITM1, LY96, TNFRSF11B inhibition). Importantly, we datamined that CREB5 regulation cluster of HIVE was involved in inflammatory response, proteolysis, biological adhesion, and negative regulation of biological process (only in HIVE terms) without positive regulation of cellular process, phosphotransferase, kinase, post-translational protein modification, ATP binding, transmembrane protein, calcium ion binding, acetylation, and hydrolase activity (only in HIVE-control patients terms), the condition was vital to inflammation and cognition impairment of HIVE. Our result demonstrated that common terms in both HIVE-control patients and HIVE included biological regulation, phosphoprotein, metabolic process, zinc, biosynthetic process, organelle, signal transduction, defense response, membrane, secreted, signal peptide, and glycoprotein, and these terms were more relative to inflammation and cognition impairment, therefore we deduced the stronger CREB5 regulation network in HIVE consistent with our number computation. It would be necessary of the stronger CREB5 regulation function to inflammation and cognition impairment of HIVE.
- Cell biochemistry and biophysics.Cell Biochem Biophys.2011 Jul;60(3):199-207. doi: 10.1007/s12013-010-9140-x.
- CREB5 computational regulation network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy. By integration of gene regulatory network infer and the database for annotation, visualization and i
- PMID 21132541
Japanese Journal
- Cyclic AMP Responsive Element Binding Proteins Are Involved in 'Emergency' Granulopoiesis through the Upregulation of CCAAT/Enhancer Binding Protein β.
- Hirai Hideyo,Kamio Naoka,Huang Gang,Matsusue Akiko,Ogino Shinpei,Kimura Nobuhiko,Satake Sakiko,Ashihara Eishi,Imanishi Jiro,Tenen Daniel G,Maekawa Taira
- PloS one 8(1), 2013-01-30
- … In contrast to the definitive role of the transcription factor, CCAAT/Enhancer binding protein α (C/EBPα), in steady-state granulopoiesis, previous findings have suggested that granulopoiesis during emergency situations, such as infection, is dependent on C/EBPβ. …
- NAID 120005242481
- Aglycone of Rh4 Inhibits Melanin Synthesis in B16 Melanoma Cells: Possible Involvement of the Protein Kinase A Pathway
- , , , , , , ,
- Bioscience, Biotechnology, and Biochemistry 77(1), 119-125, 2013
- … It significantly reduced the cyclic AMP (cAMP) level in B16 melanoma cells, and this might be responsible for the regulation down of MITF and tyrosinase. … Phosphorylation of a downstream molecule, a cAMP response-element binding protein, was significantly decreased according to Western blotting and immunofluorescence assay. …
- NAID 130004137994
- Osthole Reverses Beta-Amyloid Peptide Cytotoxicity on Neural Cells by Enhancing Cyclic AMP Response Element-Binding Protein Phosphorylation
- , , [他], , , , , ,
- Biological and Pharmaceutical Bulletin 36(12), 1950-1958, 2013
- … Our data showed that osthole reduced intracellular Aβ levels in neural cells, which was associated with decreased BACE1 protein; … osthole reversed exogenous Aβ25-35-induced cell viability loss, apoptosis, and synapsin-1 reduction, which was related to the reestablishment of phosphorylation of cyclic AMP response element-binding protein (CREB). …
- NAID 130003382071
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- Cyclic AMP Response Element-Binding Protein A information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Cyclic AMP Response Element-Binding Protein A
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★リンクテーブル★
| リンク元 | 「サイクリックAMP応答配列結合タンパク質A」 |
| 関連記事 | 「binding」「element」「cyclic」「binding protein」「response」 |
「サイクリックAMP応答配列結合タンパク質A」
「binding」
- n.
- adj.
- 結合性の
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
「element」
- n.
- 要素、成分、素。(構成)分子。(科学)元素、(数)(集合の)要素、元素、素。(行列の)要素、成分。(図形を火ｔが千都来る)要素。(文法の)要素
- (電子)素子、(光学)素子
- 関
- basal、bases、basic、basis、component、composition、constituent、elementary、factor、fundamentals、ingredient、moiety
「cyclic」
- adj.
- 環状の、環式の、周期性の、サイクリック
「binding protein」
「response」
- n.