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Differences in endogenous esterification and retention in the rat trachea between budesonide and ciclesonide active metabolite.

Lexmüller K1, Gullstrand H, Axelsson BO, Sjölin P, Korn SH, Silberstein DS, Miller-Larsson A.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2007 Oct;35(10):1788-96. Epub 2007 Jul 12.
The airway retention of inhaled glucocorticosteroids (GCs) depends largely on their lipophilicity. Inhaled budesonide (BUD) becomes highly lipophilic reversibly by the formation of esters acting as a reservoir of active BUD. Ciclesonide (CIC) was also reported to form esters after hydrolysis to acti
PMID 17627977

Heckmann JG1, Gaul C, Neundörfer B, Harazny J, Michelson G.
Journal of neurology, neurosurgery, and psychiatry.J Neurol Neurosurg Psychiatry.2003 Feb;74(2):149.
PMID 12531936

Chiral separation of several drugs using electrophoresis with dual cyclodextrin systems.

Zhu C1, Lin X, Wu J, Wei Y.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.Anal Sci.2002 Sep;18(9):1055-7.
PMID 12243405

Bioavailability of Cyclandelate from Capsules in Beagle Dogs and Dissolution Rate : Correlations with Bioavailability in Humans

KANIWA Nahoko,OGATA Hiroyasu,AOYAGI Nobuo,EJIMA Akira,TAKAHASHI Terutaka,UEZONO Yuko,IMASATO Yuu
Journal of pharmacobio-dynamics 14(3), 152-160, 1991-03
… The bioavailability in beagle dogs and the dissolution rates of cyclandelate from five capsule preparations commercially available in Japan were measured. … Food enhanced the bioavailability of cyclandelate from the capsules having the highest and lowest bioavailability in the fasted state in beagles as observed in the human study previously. …
NAID 110003637362

鹿庭なほ子 [他],緒方宏泰,青柳伸男,江島昭,佐久間昭
藥學雜誌 104(2), 175-183, 1984-02-25
… The powers of ANOVA were calculated in the bioequivalence tests of diazepam tablets, flufenamic acid capsules, nalidixic acid tablets, griseofulvin tablets and cyclandelate capsules both in humans and beagle dogs. … The estimated sizes of trials needed to detect 20% differences between the standard and test preparations tend to be larger in beagle dogs than in humans, especially in the trials of water-insoluble, neutral drugs such as griseofulvin and cyclandelate. …
NAID 110003650611

リンク元	「シクランデラート」「シクランデレート」

Cyclandelate
Systematic (IUPAC) name
	3,3,5-trimethylcyclohexyl hydroxy(phenyl)acetate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Legal status	?
Identifiers
CAS number	456-59-7
ATC code	C04AX01
PubChem	CID 2893
DrugBank	DB04838
ChemSpider	2790
UNII	4139O1OAY2
KEGG	D00286
ChEBI	CHEBI:3988
ChEMBL	CHEMBL1480987
Chemical data
Formula	C17H24O3
Mol. mass	276.37066
	SMILES O=C(OC1CC(CC(C1)(C)C)C)C(O)c2ccccc2;
	InChI InChI=1S/C17H24O3/c1-12-9-14(11-17(2,3)10-12)20-16(19)15(18)13-7-5-4-6-8-13/h4-8,12,14-15,18H,9-11H2,1-3H3 ; Key:WZHCOOQXZCIUNC-UHFFFAOYSA-N ;
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