crospovidone

クロス・ビドン

関

polyvinylpyrrolidone、povidone

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/06 01:51:39」(JST)

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Polyvinylpolypyrrolidone
Other names Polyvinyl polypyrrolidone, crospovidone, crospolividone, E1202
Identifiers
Abbreviations	PVPP
CAS number	9003-39-8
ATC code	A07BC03
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP).

The cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets. PVPP is a highly cross-linked version of PVP, making it insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force. This property makes it useful as a disintegrant in tablets.

PVPP can be used as a drug, taken as a tablet or suspension to absorb compounds (so-called endotoxins) causing diarrhoea. (Cf. bone char, charcoal.)

It is also used as a fining to extract impurities (via agglomeration followed by filtration). It is used in winemaking. Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced. One such commercial product is called Polyclar. PVPP formed bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.

PVPP has E number code E1202 and is used as a stabiliser.

References

UpToDate Contents

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• 1. 異物肉芽腫 foreign body granulomatosis

English Journal

• Further improvement of orally disintegrating tablets using micronized ethylcellulose.

• Okuda Y, Irisawa Y, Okimoto K, Osawa T, Yamashita S.SourceTowa Pharmaceutical Co., Ltd., 26-7 Ichiban-Cho, Kadoma, Osaka 571-0033, Japan.
• International journal of pharmaceutics.Int J Pharm.2012 Feb 28;423(2):351-9. Epub 2011 Nov 26.
• The aim of this study is to design a new orally disintegrating tablet (ODT) containing micronized ethylcellulose (MEC). The new ODT was prepared by physical mixing of rapidly disintegrating granules (RDGs) with MEC. To obtain RDGs, mannitol was spray-coated with a suspension of corn starch and crosp
• PMID 22138608

• No Risk of Surgical Site Infections From Residual Bacteria After Disinfection With Povidone-Iodine-Alcohol in 1014 Cases: A Prospective Observational Study.

• Tschudin-Sutter S, Frei R, Egli-Gany D, Eckstein F, Valderrabano V, Dangel M, Battegay M, Widmer AF.Source*Divisions of Infectious Diseases and Hospital Epidemiology †Clinical Microbiology ‡Department of Surgery, University Hospital, Basel, Switzerland. Ms Egly-Gany is currently employed at B. Braun Medical AGSeesatz 176204 Sempach, Switzerland.
• Annals of surgery.Ann Surg.2012 Feb 10. [Epub ahead of print]
• OBJECTIVE: We studied the impact of residual bacteria at the incision site after disinfection with polyvinylpyrrolidone (PVP or povidone)-iodine-alcohol and the correlation with postoperative surgical site infections (SSIs).BACKGROUND: Chlorhexidine-based preparations are significantly more effectiv
• PMID 22330031

• Fast and pH-dependent release of domperidone from orally disintegrating tablets.

• Assaf SM, Qandil AM, Al-Ani EA.SourceDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid 22110 , Jordan.
• Pharmaceutical development and technology.Pharm Dev Technol.2012 Feb 3. [Epub ahead of print]
• There has been growing interest in orally disintegrating tablets (ODTs) during the last decade due to their better patient acceptance and compliance. Further, drug dissolution and absorption may be significantly improved. This work describes the preparation of fast and pH-dependent release ODTs for
• PMID 22304659

Japanese Journal

• Effect of Particle Size of Drug on Conversion of Crystals to an Amorphous State in a Solid Dispersion with Crospovidone

• Sugamura Yuka,Fujii Makiko,Nakanishi Sayaka,Suzuki Ayako,Shibata Yusuke,Koizumi Naoya,Watanabe Yoshiteru
• CHEMICAL & PHARMACEUTICAL BULLETIN 59(2), 235-238, 2011
• … The SD of drugs were prepared in a mixture with crospovidone by a variety of mechanical methods, and their properties investigated by particle sizing, thermal analysis, and powder X-ray diffraction. … The reduction in particle size is considered to enable increased contact between the crospovidone and drug particles, increasing interactions between the two compounds. …
• NAID 130000405521

• 架橋型ポリビニルピロリドンを担体とした固体分散体の形成要因の解明及び錠剤への応用に関する研究

• 柴田 雄亮
• 粉体工学会誌 47(8), 569, 2010-08-10
• NAID 10026547761

Related Links

• Polyvinylpyrrolidone - Wikipedia, the free encyclopedia

However, autopsies have found that crospovidone does contribute to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone within the ...

• Polyvinylpolypyrrolidone - Wikipedia, the free encyclopedia

Polyvinyl polypyrrolidone, crospovidone, crospolividone, E1202 ... Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP).

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リンク元	「polyvinylpyrrolidone」「クロスポビドン」「povidone」

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crospovidone、povidone

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crospovidone

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ポリビニルピロリドン、ポビドン

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crospovidone、polyvinylpyrrolidone