Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/20 18:14:58」(JST)

Croconazole (INN) is an imidazole antifungal.

References

Croconazole

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations.

El-Badry M1, Fetih G, Shakeel F.
Drug delivery.Drug Deliv.2014 Feb;21(1):34-43. doi: 10.3109/10717544.2013.843610. Epub 2013 Oct 14.
The aim of this study was to develop liposomal-based (LBGF) and micro-emulsion-based (MBGF) gel formulations of croconazole to compare their topical delivery potential. Conventional gels were also prepared using various polymers such as sodium carboxymethyl cellulose (SCMC), Poloxamer 407, Carbopol
PMID 24116896

Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans.

Scherr N1, Röltgen K, Witschel M, Pluschke G.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2012 Dec;56(12):6410-3. doi: 10.1128/AAC.01383-12. Epub 2012 Sep 24.
An alamarBlue-based growth inhibition assay has been adapted for the thermosensitive and slow-growing pathogen Mycobacterium ulcerans. The standardized test procedure enables medium-throughput screening of preselected compound libraries. Testing of a set of 48 azoles with known antifungal activity l
PMID 23006761

Synthesis and antifungal activity of 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives: exploring the scaffold flexibility.

Emami S1, Kazemi-Najafabadi M, Pashangzadeh S, Foroumadi A, Faramarzi MA, Samadi N, Falahati M, Fateh R, Ashrafi-Khozani M.
Chemical biology & drug design.Chem Biol Drug Des.2011 Dec;78(6):979-87. doi: 10.1111/j.1747-0285.2011.01243.x. Epub 2011 Oct 28.
Based on the N-(phenethyl)azole backbone of azole antifungals, we designed 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives 2 and 3, containing benzyloxyphenyl scaffold of croconazole. Also these compounds can be considered as flexible analogs, resulted from C2-C3 disconnection of 3'-chloro
PMID 21920030

Croconazole
Systematic (IUPAC) name
	1-(1-{2-[(3-chlorophenyl)methoxy]phenyl}ethenyl)-1H-imidazole
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical
Legal status
Legal status	℞ (Prescription only);
Identifiers
CAS Number	77175-51-0
ATC code	none
PubChem	CID 2880
ChemSpider	2777
UNII	446254H55G
KEGG	D07752
ChEMBL	CHEMBL27289
Chemical data
Formula	C18H15ClN2O
Molar mass	310.77 g/mol
	SMILES Clc1cccc(c1)COc3c(\C(=C)n2ccnc2)cccc3 ;