WordNet

a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
carbonated drink with fruit syrup and a little phosphoric acid
an amino acid that does not occur in proteins but is found in the muscle tissue of vertebrates both in the free form and as phosphocreatine; supplies energy for muscle contraction (同)creatin

PrepTutorEJDIC

〈U〉リン酸塩 / 《複数形で》リン酸肥料

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/08 06:57:26」(JST)

wiki en

Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated creatine molecule that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle and the brain.

Chemistry

Phosphocreatine is formed from parts of three amino acids: arginine (Arg), glycine (Gly), and methionine (Met). It can be synthesized by formation of guanidinoacetate from Arg and Gly (in kidney) followed by methylation (S-adenosyl methionine is required) to creatine (in liver), and phosphorylation by creatine kinase (ATP is required) to phosphocreatine (in muscle); catabolism: dehydration to form the cyclic Schiff base creatinine. Phosphocreatine is synthesized in the liver and transported to the muscle cells, via the bloodstream, for storage.

The creatine phosphate shuttle facilitates transport of high energy phosphate from mitochondria.

Function

Phosphocreatine can anaerobically donate a phosphate group to ADP to form ATP during the first 2 to 7 seconds following an intense muscular or neuronal effort. Conversely, excess ATP can be used during a period of low effort to convert creatine to phosphocreatine. The reversible phosphorylation of creatine (i.e., both the forward and backward reaction) is catalyzed by several creatine kinases. The presence of creatine kinase (CK-MB, MB for muscle/brain) in blood plasma is indicative of tissue damage and is used in the diagnosis of myocardial infarction.^[1] The cell's ability to generate phosphocreatine from excess ATP during rest, as well as its use of phosphocreatine for quick regeneration of ATP during intense activity, provides a spatial and temporal buffer of ATP concentration. In other words, phosphocreatine acts as high-energy reserve in a coupled reaction; the energy given off from donating the phosphate group is used to regenerate the other compound - in this case, ATP. Phosphocreatine plays a particularly important role in tissues that have high, fluctuating energy demands such as muscle and brain.

History

The discovery of phosphocreatine^[2]^[3] was reported by Grace and Philip Eggleton of the University of Cambridge^[4] and separately by Cyrus Fiske and Yellapragada Subbarow of the Harvard Medical School^[5] in 1927. A few years later David Nachmansohn, working under Meyerhof at the Kaiser Wilhelm Institute in Dahlem, Berlin, contributed to the understanding of the phosphocreatine's role in the cell.^[3]

References

^ Schlattner, U.; Tokarska-Schlattner, M., and Wallimann, T. (2006). "Mitochondrial creatine kinase in human health and disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1762 (2): 164–180. doi:10.1016/j.bbadis.2005.09.004. PMID 16236486.
^ Saks, Valdur (2007). Molecular system bioenergetics: energy for life. Weinheim: Wiley-VCH. p. 2. ISBN 978-3-527-31787-5.
^ ^a ^b Ochoa, Severo (1989). Sherman, E. J.; National Academy of Sciences, eds. David Nachmansohn. Biographical Memoirs 58. National Academies Press. pp. 357–404. ISBN 978-0-309-03938-3.
^ Eggleton, Philip; Eggleton, Grace Palmer (1927). "The inorganic phosphate and a labile form of organic phosphate in the gastrocnemius of the frog". Biochemical Journal 21 (1): 190–195. PMC 1251888. PMID 16743804.
^ Fiske, Cyrus H.; Subbarao, Yellapragada (1927). "The nature of the 'inorganic phosphate' in voluntary muscle". Science 65 (1686): 401–403. doi:10.1126/science.65.1686.401. PMID 17807679.

External links

Human Metabolome Database at the University of Alberta

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. クレアチン代謝の先天性疾患 congenital disorders of creatine metabolism
2. 神経筋疾患の評価における筋酵素 muscle enzymes in the evaluation of neuromuscular diseases
3. 低リン血症の徴候および症状 signs and symptoms of hypophosphatemia
4. 横紋筋融解症の原因 causes of rhabdomyolysis
5. 新生児における筋緊張低下を引き起こす末梢神経および筋肉の障害に関する概要 overview of peripheral nerve and muscle disorders causing hypotonia in the newborn

English Journal

A proton spectroscopy study of white matter in children with autism.

Hardan AY1, Fung LK2, Frazier T3, Berquist SW2, Minshew NJ4, Keshavan MS5, Stanley JA6.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2016 Apr 3;66:48-53. doi: 10.1016/j.pnpbp.2015.11.005. Epub 2015 Nov 16.
White matter abnormalities have been described in autism spectrum disorder (ASD) with mounting evidence implicating these alterations in the pathophysiology of the aberrant connectivity reported in this disorder. The goal of this investigation is to further examine white matter structure in ASD usin
PMID 26593330

Diagnostic approaches to predict persistent post-traumatic symptoms after mild traumatic brain injury - a literature review.

Studerus-Germann AM1,2, Thiran JP3, Daducci A3, Gautschi OP4.
The International journal of neuroscience.Int J Neurosci.2016 Apr;126(4):289-98. doi: 10.3109/00207454.2015.1033620. Epub 2015 Jul 28.
Mild traumatic brain injury (mTBI) is one of the most frequently diagnosed neurological disorders in emergency departments. Although there are established recommendations for the diagnosis and treatment in the acute stage, there is an on-going debate in which diagnostic methods and risk factors pred
PMID 26000929

Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.

Sun Z1,2, Lan X3, Ahsan A1, Xi Y2, Liu S1, Zhang Z1, Chu P1, Song Y1, Piao F4, Peng J1, Lin Y1, Han G1, Tang Z5.
Apoptosis : an international journal on programmed cell death.Apoptosis.2016 Mar;21(3):283-97. doi: 10.1007/s10495-015-1210-5.
Phosphocreatine (PCr) is an exogenous energy substance, which provides phosphate groups for adenosine triphosphate (ATP) cycle and promotes energy metabolism in cells. However, it is still unclear whether PCr has influenced on mitochondrial energy metabolism as well as oxidative phosphorylation (OXP
PMID 26708229

Japanese Journal

Involvement of the phosphatidylinositol kinase pathway in augmentation of ATP-sensitive K+ channel currents by hypo-osmotic stress in rat ventricular myocytes

Mitsuyama Hirofumi,Yokoshiki Hisashi,Irie Yuki,Watanabe Masaya,Mizukami Kazuya,Tsutsui Hiroyuki
Canadian journal of physiology and pharmacology 91(9), 686-692, 2013-09
… Augmentation of I-K,I-ATP during hypo-osmotic stress was attenuated by wortmannin (50 mu mol/L), an inhibitor of phosphatidylinositol 3- and 4-kinases, but not by (i) phalloidin (30 mu mol/L), an actin filament stabilizer, (ii) the absence of Ca2+ from the internal and external solutions, and (iii) the presence of creatine phosphate (3 mmol/L), which affects creatine kinase regulation of the K-ATP channels. …
NAID 120005333605

シグナスオートCKの安定化技術 (特集検査技術の新たな展望(1))

加藤大介,中尾友作,飯塚直美 [他]
生物試料分析 = Journal of analytical bio-science 36(4), 303-309, 2013
NAID 40019884655

Related Pictures

Sodium Creatine Phosphate 922-32-7 | 東京化成工業株式会社 Creatine Phosphate 300 г ᐈ BioTech — купить в Днепре, отзывы Creatine Phosphate (300 g) - купить Креатин BioTech в Киеве и Creatine Phosphate by BIOTECH USA (300 grams) Creatine Phosphate 300 gr BiotechUSA Creatine Phosphate 300 g | Pilulka24.sk online lekáreň POWER SPORT - Спортивное питание BioTech Creatine Phosphate 5000 300 г Creatine Phosphate BioTech USA 300g [promocja] • Sklep BCAA.pl

★リンクテーブル★

リンク元	「クレアチンリン酸」「ホスホクレアチン」
関連記事	「phosphate」

「クレアチンリン酸」

Phosphocreatine
Names
	IUPAC name N-Methyl-N-(phosphonocarbamimidoyl)glycine
	Other names Creatine phosphate; phosphorylcreatine; creatine-P; phosphagen; fosfocreatine
Identifiers
CAS Number	67-07-2
Abbreviations	PCr
ChemSpider	567
EC Number	200-643-9
Jmol interactive 3D	Image; Image
PubChem	587
UNII	020IUV4N33
	InChI InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12) Key: DRBBFCLWYRJSJZ-UHFFFAOYSA-N ; InChI=1/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12) Key: DRBBFCLWYRJSJZ-UHFFFAOYAF ;
	SMILES OC(CN(C)C(N)=NP(O)(O)=O)=O ; CN(CC(=O)O)C(=N)NP(=O)(O)O ;
Properties
Chemical formula	C4H10N3O5P
Molar mass	211.11 g·mol−1
Pharmacology
ATC code	C01EB06
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references