WordNet

a corticosteroid hormone (trade name Cortone Acetate) normally produced by the adrenal cortex; is converted to hydrocortisone (同)Cortone Acetate
an enzyme that catalyses the biochemical reduction of some specified substance

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Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging.

Hassan-Smith ZK1, Morgan SA, Sherlock M, Hughes B, Taylor A, Lavery G, Tomlinson JW, Stewart PM.
The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2015 May 19:jc20151516. [Epub ahead of print]
CONTEXT: Cushing's syndrome is characterized by marked changes in body composition (sarcopenia, obesity, and osteoporosis) that have similarities with those seen in aging. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts glucocorticoids to their active form (cortisone to cortisol in hum
PMID 25989394

Tiganescu A1, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM.
Experimental dermatology.Exp Dermatol.2015 May;24(5):370-6. doi: 10.1111/exd.12682.
Detrimental consequences of ultraviolet radiation (UVR) in skin include photoageing, immunosuppression and photocarcinogenesis, processes also significantly regulated by local glucocorticoid (GC) availability. In man, the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) generates the acti
PMID 25739654

Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women.

Stomby A1, Simonyte K1, Mellberg C1, Ryberg M1, Stimson RH2, Larsson C3, Lindahl B1, Andrew R2, Walker BR2, Olsson T4.
International journal of obesity (2005).Int J Obes (Lond).2015 May;39(5):814-9. doi: 10.1038/ijo.2014.188. Epub 2014 Oct 28.
BACKGROUND/OBJECTIVES: Tissue-specific glucocorticoid metabolism is altered in obesity, and may increase cardiovascular risk. This dysregulation is normalized by short-term calorie restriction and weight loss, an effect that varies with dietary macronutrient composition. However, tissue-specific glu
PMID 25349058

Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

小島元子,佐藤宏治,五味渕大平,伊藤信雄,金真治,福地総逸,宮地幸隆
Folia Endocrinologica Japonica 66(5), 584-596, 1990
… Glycyrrhetinic acid inhibits both hepatic Δ<SUP>4</SUP>-5-reductase and 11 β-hydroxysteroid dehydrogenase in a dose-dependent manner, resulting in the decrease of conversion of cortisol to cortisone, dihydrocortisol and tetrahydrocortisol in rats. …
NAID 130001937292

富田勤,斎藤和雄,高桑栄松
日本衛生学雑誌 31(2), 361-366, 1976
… In this paper, the effects of lead acetate on the activities of Δ4-reductase and 5β-reductase to cortisol, cortisone, testosterone and Δ4-androstene-3, 17-dione and of dehydrogenase to 3α-hydroxysteroid and 3β-hydroxysteroid were examined. …
NAID 130001000587